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UAB Digital Repository of Documents 6 records found  Search took 0.00 seconds. 
1.
27 p, 369.7 KB Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Roda, Alejandro Ramos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Rivera-Hernández, Geovanny (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The intracellular deposition of amyloid-beta (A beta) peptides has been described in the brains of both Alzheimer's disease (AD) patients and animal models. A correlation between the intracellular amyloid burden and neurodegeneration has recently been reported in a triple-transgenic AD (3xTg-AD) murine model. [...]
2019 - 10.3233/JAD-190484
Journal of Alzheimer's disease, Vol. 70 Núm. 4 (2019) , p. 1069-1091  
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2.
19 p, 18.6 MB Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect / Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bronsoms, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
ScFv-h3D6 has been shown as an efficient therapy in the 3xTg-AD mouse model of Alzheimer's Disease. Because one of the major bottlenecks for the therapeutic uses of proteins produced in Escherichia coli is their potential contamination with endotoxins, LPS were extensively removed by a rather low-efficient, expensive, and time-consuming purification step. [...]
2017 - 10.1371/journal.pone.0181480
PloS one, Vol. 12 (August 2017) , art. e0181480  
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3.
21 p, 2.6 MB Cognitive impairment in the 3xTg-AD mouse model of Alzheimer's disease is reduced by Abeta-immunotherapy and cognitive stimulation / Ramos Roda, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Clinical symptoms of Alzheimer's Disease (AD) include behavioral alterations and cognitive impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice. Specifically, behavioral alterations are first detected when mice are at around 2. [...]
2020 - 10.3390/pharmaceutics12100944
Pharmaceutics, Vol. 12, Num. 10 (October 2020) , art. 944  
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4.
20 p, 2.9 MB Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The success of the targeting of amyloid-β (Aβ) oligomers through immunotherapy in Alzheimer's disease (AD) mouse models has not been translated into the clinics. The use of single- chain variable fragments (scFvs) has been proposed to prevent the potential severe effects of full-length mAbs by precluding crystallizable fraction-mediated microglia activation. [...]
2019 - 10.1371/journal.pone.0217793
PloS one, Vol. 14, Issue 5 (May 2019) , art. e0217793  
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5.
210 p, 4.8 MB New insights into Alzheimer's disease : further characterization of the 3xTg-AD mouse model and a pharmacological approach with scFv-h3D6 / Esquerda-Canals, Gisela ; Martí-Clúa, Joaquín, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Villegas Hernández, Sandra, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
La malaltia d'Alzheimer és el desordre neurodegeneratiu més comú arreu del món. L'acumulació del pèptid beta-amiloide (Aβ) és el principal factor en el seu patomecanisme. El model murí 3xTg-AD ha esdevingut un dels models més populars d'aquesta malaltia perquè manifesta la patologia Aβ i tau seguint un patró regional i temporal similar als humans. [...]
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. The accumulation of the amyloid-β peptide (Aβ) is considered a key factor in its pathomechanism. The 3xTg-AD mouse model has become one of the most popular models of AD since it is described to progressively develop Aβ and tau pathologies by following a regional- and temporal-pattern analogous to human. [...]
[Bellaterra] : Universitat Autònoma de Barcelona, 2018.  
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6.
17 p, 1.5 MB Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragmen / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. [...]
2013 - 10.4161/mabs.25428
MAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 660-664  
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