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13 p, 4.1 MB |
New variants of alpha-1-antitrypsin : structural simulations and clinical expression
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Gonzalez, Angel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Núñez, Alexa (Hospital Universitari Vall d'Hebron) ;
Farago, Georgina (Hospital Universitari Vall d'Hebron) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron) ;
Orriols, Gerard (Hospital Universitari Vall d'Hebron) ;
Gabriel-Medina, Pablo (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron)
Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver and lung disease. The characterization at structural level of novel pathogenic SERPINA1 mutants coding for circulating AAT could provide novel insights into the mechanisms of AAT misfolding. [...]
2022 -  10.1186/s12931-022-02271-8
Respiratory Research, Vol. 23 (december 2022)
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3.
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7.6 MB |
Crioablación percutánea en el tratamiento del carcinoma renal
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Abu-Suboh Abadia, Amad ;
Rodríguez Faba, Óscar, dir. ;
Esquinas López, Cristina, dir. ;
Palou, Juan, dir.
L'objectiu d'aquest treball és aprofundir en el coneixement dels resultats oncològics de la crioblació percutània guiada per imatge en pacients clínicament diagnosticats de massa renal a l'estadi clínic T1a. [...]
El objetivo de este trabajo es profundizar en el conocimiento de los resultados oncológicos de la crioblación percutánea guiada por imagen en pacientes clínicamente diagnosticados de masa renal en estadio clínico T1a. [...]
The objective of this work is to deepen the knowledge of the oncological results of image-guided percutaneous cryoablation in patients clinically diagnosed with renal mass in clinical stage T1a. The objective is to know if the characteristics and comorbidities of patients undergoing percutaneous cryoablation of a renal tumor have a negative impact on the success of the percutaneous technique and, at the same time, to assess if these are associated with a greater number of complications Identify if the systems of renal nephrometry, used in urological surgery, for the preoperative anatomical evaluation of tumors (R. [...]
2022
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13 p, 844.8 KB |
Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency
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Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Núñez, Alexa (Universitat Autònoma de Barcelona) ;
Esquinas, Cristina (Universitat Autònoma de Barcelona) ;
Torres-Durán, María (Complexo Hospitalario Universitario de Vigo) ;
Rodriguez Hermosa, Juan Luis (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Calle Rubio, Myriam (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Tubio-Pérez, Ramón (Instituto de Investigación Sanitaria Galicia Sur) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez, Esther (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. [...]
2021 - 10.3390/jcm10081724
Journal of clinical medicine, Vol. 10 (april 2021)
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11 p, 2.2 MB |
Trends in Diagnosis of Alpha-1 Antitrypsin Deficiency Between 2015 and 2019 in a Reference Laboratory
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Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Núñez, Alexa (Universitat Autònoma de Barcelona) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Ruiz, Gerard (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron)
Alpha-1 antitrypsin deficiency (AATD) remains largely underdiagnosed despite recommendations of healthcare institutions and programmes designed to increase awareness. The objective was to analyse the trends in AATD diagnosis during the last 5 years in a Spanish AATD reference laboratory. [...]
2020 - 10.2147/COPD.S269641
International journal of COPD, Vol. 15 (october 2020) , p. 2421-2431
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9 p, 605.3 KB |
Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema
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Matas, Jessica (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llorenç, Victor (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fonollosa, Alex (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Diaz Valle, David (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de la Maza, Maria Teresa Sainz (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Figueras-Roca, Marc (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Artaraz, Joseba (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Berasategui, Barbara (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Mesquida, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Molins, Blanca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). [...]
2020 - 10.3389/fimmu.2020.579005
Frontiers in immunology, Vol. 11 (september 2020)
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10 p, 685.5 KB |
Association Between Routine Blood Biomarkers and Clinical Phenotypes and Exacerbations in Chronic Obstructive Pulmonary Disease
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Núñez, Alexa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Marras, Viviana (Respiratory Unit, AOU Sassari) ;
Harlander, Matevz (University Medical Centre Ljubljana) ;
Mekov, Evgeni (Medical University of Sofia) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Turel, Matjaz (University Medical Centre Ljubljana) ;
Lestan, David (University Medical Centre Ljubljana) ;
Petkov, Rosen (Medical University of Sofia) ;
Yanev, Nikolay (Medical University of Sofia) ;
Pirina, Pietro (Respiratory Unit, AOU Sassari) ;
Negri, Silvia (Respiratory Unit, AOU Sassari) ;
Miravitlles, Marc (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations. [...]
2020 - 10.2147/COPD.S240720
International journal of COPD, Vol. 15 (march 2020) , p. 681-690
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11 p, 497.0 KB |
Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
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Matas, Jessica (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llorenç, Victor (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fonollosa, Alex (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Diaz Valle, David (Hospital Clínico San Carlos (Madrid)) ;
Berasategui, Barbara (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Mesquida, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Artaraz, Joseba (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Ríos, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Aims We aimed to investigate predictive factors for visual and anatomic outcomes in patients with macular edema secondary to non-infectious uveitis. Material and methods We conducted a multicenter, prospective, observational, 12-month follow-up study. [...]
2019 - 10.1371/journal.pone.0210799
PloS one, Vol. 14 Núm. 1 (january 2019) , p. e0210799
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11 p, 4.8 MB |
Geographical distribution of COPD prevalence in Europe, estimated by an inverse distance weighting interpolation technique
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Blanco Guillermo, Ignacio (Sociedad Española de Neumología y Cirugía Torácica) ;
Diego, Isidro (Universidad de Oviedo) ;
Bueno, Patricia (Hospital de Jarrio, Asturias) ;
Fernández, Eloy (Hospital Universitario de Cabueñes (Gijón)) ;
Casas-Maldonado, Francisco (Hospital Universitario San Cecilio (Granada)) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Soriano, Joan B.. (Hospital Universitario de la Princesa (Madrid)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Existing data on COPD prevalence are limited or totally lacking in many regions of Europe. The geographic information system inverse distance weighted (IDW) interpolation technique has proved to be an effective tool in spatial distribution estimation of epidemiological variables, when real data are few and widely separated. [...]
2017 - 10.2147/COPD.S150853
International journal of COPD, Vol. 13 (december 2017) , p. 57-67
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9 p, 577.2 KB |
Self-reported daily walking time in COPD : relationship with relevant clinical and functional characteristics
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Ramon, Maria A. (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Pleguezuelos, Eulogio (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Molina, Jesús (Centro de Salud Francia, Madrid) ;
Quintano, José A.. (Centro de Salud de Lucena I, Córdoba) ;
Roman-Rodríguez, Miguel (Centre de Salut de Son Pisà, Palma de Mallorca) ;
Naberan, Karlos (Centro de Salud Campo de Belchite, Zaragoza) ;
Llor, Carl (Institut Català de la Salut) ;
Roncero, Carlos (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron)
Quantifying physical activity in chronic obstructive pulmonary disease (COPD) is important as physical inactivity is related to poor health outcomes. This study analyzed the relationship between patients' self-reported daily walking time and relevant characteristics related to COPD severity. [...]
2017 - 10.2147/COPD.S128234
International journal of COPD, Vol. 12 (april 2017) , p. 1173-1181
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