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UAB Digital Repository of Documents 8 records found  Search took 0.02 seconds. 
1.
6 p, 909.0 KB The consequences of cohesin mutations in myeloid malignancies / Bhattacharya, Shubhra Ashish (Universitat Autònoma de Barcelona) ; Dias, Eve (Universitat Autònoma de Barcelona) ; Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. [...]
2023 - 10.3389/fmolb.2023.1319804
Frontiers in Molecular Biosciences, Vol. 10 (2023) , p. 1319804  
Detailed record - Creative Commons
2.
17 p, 4.4 MB Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras / Fernández-Millán, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vázquez-Monteagudo, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Design of novel antibiotics to fight antimicrobial resistance is one of the first global health priorities. Novel protein-based strategies come out as alternative therapies. Based on the structure-function knowledge of the RNase A superfamily we have engineered a chimera that combines RNase 1 highest catalytic activity with RNase 3 unique antipathogen properties. [...]
2022 - 10.3389/fmolb.2022.964717
Frontiers in Molecular Biosciences, Vol. 9 (September 2022) , art. 964717  
Detailed record - Creative Commons
3.
8 p, 1.2 MB SGnn : A Web Server for the Prediction of Prion-Like Domains Recruitment to Stress Granules Upon Heat Stress / Iglesias, Valentin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Santos, Jaime (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Santos-Suárez, Juan (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Proteins bearing prion-like domains (PrLDs) are essential players in stress granules (SG) assembly. Analysis of data on heat stress-induced recruitment of yeast PrLDs to SG suggests that this propensity might be connected with three defined protein biophysical features: aggregation propensity, net charge, and the presence of free cysteines. [...]
2021 - 10.3389/fmolb.2021.718301
Frontiers in Molecular Biosciences, Vol. 8 (August 2021) , art. 718301  
Detailed record - Creative Commons
4.
3 p, 582.4 KB Editorial : Molecular determinants of protein assemblies in health and disease / Kroschwald, Sonja (ETH Zurich. Institut für Biochemie) ; Arunagiri, Anoop (University of Michigan. Department of Internal Medicine) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ranganathan, Srivastav (Harvard University. Department of Chemistry and Chemical Biology) ; Kohler, Verena (University of Graz. Institute of Molecular Biosciences) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
2022 - 10.3389/fmolb.2022.1107686
Frontiers in Molecular Biosciences, Vol. 9 (December 2022) , art. 1107686  
Detailed record - Creative Commons
5.
7 p, 1.0 MB Phase Separation Drives SARS-CoV-2 Replication : A Hypothesis / Vandelli, Andrea (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vocino, Giovanni (University of Bologna) ; Tartaglia, Gian Gaetano (Institució Catalana de Recerca i Estudis Avançats)
Identifying human proteins that interact with SARS-CoV-2 genome is important to understand its replication and to identify therapeutic strategies. Recent studies have unveiled protein interactions of SARS-COV-2 in different cell lines and through a number of high-throughput approaches. [...]
2022 - 10.3389/fmolb.2022.893067
Frontiers in Molecular Biosciences, Vol. 9 (May 2022) , art. 893067  
Detailed record - Creative Commons
6.
14 p, 1.5 MB Multiple Layered Control of the Conjugation Process of the Bacillus subtilis Plasmid pLS20 / Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa) ; Boer, Roeland (ALBA Laboratori de Llum de Sincrotró) ; Ares, Saúl (Centro Nacional de Biotecnología. Departamento de Biología de Sistemas) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Rojo, Fernando (Centro Nacional de Biotecnología. Department of Microbial Biotechnology) ; Luque-Ortega, Juan Román (Centro de Investigaciones Biológicas (Madrid)) ; Wu, Ling Juan (Newcastle University. Centre for Bacterial Cell Biology, Biosciences Institute)
Bacterial conjugation is the main horizontal gene transfer route responsible for the spread of antibiotic resistance, virulence and toxin genes. During conjugation, DNA is transferred from a donor to a recipient cell via a sophisticated channel connecting the two cells. [...]
2021 - 10.3389/fmolb.2021.648468
Frontiers in Molecular Biosciences, Vol. 8 (March 2021) , art. 648468  
Detailed record - Creative Commons
7.
11 p, 711.6 KB Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain / Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Díaz Sanzo, Óscar (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Dalton, James A. R.. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
UDTAULÍ.
As a class C GPCR and regulator of synaptic activity, mGlu5 is an attractive drug target, potentially offering treatment for several neurologic and psychiatric disorders. As little is known about the activation mechanism of mGlu5 at a structural level, potential of mean force calculations linked to molecular dynamics simulations were performed on the mGlu5 transmembrane domain crystal structure to explore various internal mechanisms responsible for its activation. [...]
2020 - 10.3389/fmolb.2020.00038
Frontiers in Molecular Biosciences, Vol. 7 (march 2020)  
Detailed record - Creative Commons
8.
13 p, 5.2 MB The Verrucomicrobia LexA-Binding Motif : Insights into the Evolutionary Dynamics of the SOS Response / Erill, Ivan (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Kiliç, Sefa (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Barbé García, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division, and translesion synthesis. In contrast to other regulatory systems, the composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, have been shown to vary greatly across bacterial clades, making it an ideal system to study the co-evolution of transcription factors and their regulons. [...]
2016 - 10.3389/fmolb.2016.00033
Frontiers in Molecular Biosciences, Vol. 3 (july 2016) , art. 33  
Detailed record - Creative Commons

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