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11.
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9 p, 297.4 KB |
Emerging Translational Research in Neurological and Psychiatric Diseases : From In Vitro to In Vivo Models
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Tanaka, Masaru (University of Szeged, Hungary) ;
Szabó, Ágnes (University of Szeged, Hungary) ;
Vécsei, László (University of Szeged, Hungary) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
2023 -  10.3390/ijms242115739
International journal of molecular sciences, Vol. 24, Num.21 (october 2023)
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12.
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25 p, 4.8 MB |
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities
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Kakularam, Kumar R. (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ;
Canyelles-Niño, Miquel (Universitat Autònoma de Barcelona. Departament de Química) ;
Chen, Xin (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kuhn, Hartmut (Charité-Universitätsmedizin Berlin. Department of Biochemistry)
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy murinized the specificity of the human enzyme. [...]
2023 - 10.3390/ijms241210046
International journal of molecular sciences, Vol. 24, Issue 12 (June 2023) , art. 10046
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13.
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15 p, 2.2 MB |
Recovering What Matters : High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates
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Casonato Melo, Cristiane (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Fux, Alexandra C. (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Himly, Martin (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Schlahsa, Laura (Miltenyi Biotec B.V. & Co) ;
Siewert, Christiane (Miltenyi Biotec B.V. & Co) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Gessner, Isabel (Miltenyi Biotec B.V. & Co) ;
Fauerbach, Jonathan A. (Miltenyi Biotec B.V. & Co)
Endotoxins or lipopolysaccharides (LPS), found in the outer membrane of Gram-negative bacterial cell walls, can stimulate the human innate immune system, leading to life-threatening symptoms. Therefore, regulatory limits for endotoxin content apply to injectable pharmaceuticals, and excess LPS must be removed before commercialization. [...]
2023 - 10.3390/ijms241813971
International journal of molecular sciences, Vol. 24, Issue 18 (September 2023) , art. 13971
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14.
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25 p, 4.6 MB |
Gas-Phase vs. Grain-Surface Formation of Interstellar Complex Organic Molecules : A Comprehensive Quantum-Chemical Study
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Martínez-Bachs, Berta (Universitat Autònoma de Barcelona. Departament de Química) ;
Rimola, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Several organic chemical compounds (the so-called interstellar complex organic molecules, iCOMs) have been identified in the interstellar medium (ISM). Examples of iCOMs are formamide (HCONH), acetaldehyde (CHCHO), methyl formate (CHOCHO), or formic acid (HCOOH). [...]
2023 - 10.3390/ijms242316824
International journal of molecular sciences, Vol. 24, Num. 23 (November 2023) , art. 16824
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15.
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14 p, 1.6 MB |
Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles
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Barguilla, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Candela-Noguera, Vicente (Universitat Politècnica de València) ;
Oliver, Patrick (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Annangi, Balasubramanyam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Díez, Paula (Universitat Politècnica de València) ;
Aznar, Elena (Universitat Politècnica de València) ;
Martínez-Máñez, Ramón (Universitat Politècnica de València) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Martínez, Maria Dolores (Universitat Politècnica de València)
Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. [...]
2023 - 10.3390/ijms242216158
International journal of molecular sciences, Vol. 24, Issue 22 (November 2023) , art. 16158
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16.
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17.
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23 p, 5.8 MB |
Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats
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Serra, Maria Pina (University of Cagliari) ;
Sanna, Francesco (University of Cagliari) ;
Boi, Marianna (University of Cagliari) ;
Trucas, Marcello (University of Cagliari) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Corda, Maria Giuseppa (University of Cagliari) ;
Giorgi, Osvaldo (University of Cagliari) ;
Quartu, Marina (University of Cagliari)
In this article, we describe the effects of tail pinch (TP), a mild acute stressor, on the levels of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor B (trkB) proteins in the hippocampus (HC) of the outbred Roman High- (RHA) and Low-Avoidance (RLA) rats, one of the most validated genetic models for the study of fear/anxiety- and stress-related behaviors. [...]
2023 - 10.3390/ijms24119498
International journal of molecular sciences, Vol. 24 (may 2023)
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18.
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21 p, 2.8 MB |
Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
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Parra-Perez, Alberto M. (GENYO. Centre for Genomics and Oncological Research: Pfizer. Universidad de Granada) ;
Pérez-Jiménez, Amalia (Universidad de Granada. Departamento de Zoología. Facultad de Ciencias) ;
Gris-Cárdenas, Isabel (CIC bioGUNE. Centre for Cooperative Research in Biosciences) ;
Bonel-Pérez, Gloria C. (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Carrasco-Díaz, Luis Miguel (Institut d'Investigació Biomèdica Sant Pau) ;
Mokhtari, khalida (Mohammed I University. Laboratory of Bioresources. Biotechnologies. Ethnopharmacology and Health. Department of Biology. Faculty of Sciences) ;
García-Salguero, Encarnacion Leticia (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Lupiáñez, José Antonio (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Rufino-Palomares, Eva E. (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Universitat Autònoma de Barcelona
Hydroxytyrosol (HT), the main representative of polyphenols of olive oil, has been described as one of the most powerful natural antioxidants, also showing anti-inflammatory, antimicrobial, cardioprotective and anticancer activity in different type of cancers, but has been little studied in hematological neoplasms. [...]
2022 - 10.3390/ijms23137053
International journal of molecular sciences, Vol. 23 Núm. 13 (july 2022) , p. 7053
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19.
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18 p, 2.0 MB |
Establishing In-House Cutoffs of CSF Alzheimer's Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort
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Orellana, Adelina (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
García-gonzález, Pablo (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Rosende-roca, Maitee (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Vargas, Liliana (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Esteban de Antonio, Ester (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Narvaiza, Leire (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pytel, Vanesa (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, Marta. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Background: Clinical diagnosis of Alzheimer's disease (AD) increasingly incorporates CSF biomarkers. However, due to the intrinsic variability of the immunodetection techniques used to measure these biomarkers, establishing in-house cutoffs defining the positivity/negativity of CSF biomarkers is recommended. [...]
2022 - 10.3390/ijms23136891
International journal of molecular sciences, Vol. 23 Núm. 13 (july 2022) , p. 6891
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20.
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18 p, 1.0 MB |
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia : Evidence from Genetic and Neuroimaging Approaches
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Almodóvar-Payá, Carmen (Instituto de Salud Carlos III) ;
Guardiola-Ripoll, Maria (Instituto de Salud Carlos III) ;
Giralt López, Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gallego, Carme (Molecular Biology Institute of Barcelona) ;
Salgado-Pineda, Pilar (Centro de Investigación Biomédica en Red de Salud Mental) ;
Miret, Salvador (Hospital Universitari Santa Maria de Lleida) ;
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental) ;
Muñoz, María J. (Complex Assistencial en Salut Mental Benito Menni (Sant Boi de Llobregat, Catalunya)) ;
Lázaro, Luisa (Hospital Clínic i Provincial de Barcelona) ;
Guerrero-Pedraza, Amalia (Complex Assistencial en Salut Mental Benito Menni (Sant Boi de Llobregat, Catalunya)) ;
Parellada, Mara (Instituto de Investigación Sanitaria del Hospital Gregorio Marañón) ;
Carrión, María I. (Hospital Universitario de Navarra) ;
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ;
Maristany, Teresa (Hospital Sant Joan de Déu Fundació de Recerca) ;
Sarró, Salvador (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fañanás, Lourdes (Universitat de Barcelona. Institut de Biomedicina) ;
Callado, Luis F. (Instituto de Salud Carlos III) ;
Arias, Barbara (Universitat de Barcelona. Institut de Biomedicina) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fatjó-Vilas, Mar (Departament de Biologia Evolutiva, Ecología i Ciències Ambientals, Universitat de Barcelona (UB))
Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. [...]
2022 - 10.3390/ijms23137456
International journal of molecular sciences, Vol. 23 Num. 13 (july 2022)
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