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50 p, 28.5 MB |
Pan-cancer proteogenomics connects oncogenic drivers to functional states
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Li, Yize (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tokheim, Collin (Harvard T.H. Chan School of Public Health) ;
Bailey, Matthew H. (Brigham Young University) ;
Yaron, Tomer (Weill Cornell Medicine) ;
Stathias, Vasileios (University of Miami Miller School of Medicine) ;
Geffen, Yifat (Massachusetts General Hospital (Boston)) ;
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cao, Song (McDonnell Genome Institute) ;
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Liu, Wenke (NYU Grossman School of Medicine) ;
Wyczalkowski, Matthew A. (McDonnell Genome Institute) ;
Song, Yizhe (McDonnell Genome Institute) ;
Storrs, Erik P. (McDonnell Genome Institute) ;
Wendl, Michael C. (Washington University in St. Louis) ;
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units)) ;
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Liang, Wen-Wei (McDonnell Genome Institute) ;
Terekhanova, Nadezhda V. (McDonnell Genome Institute) ;
Martins Rodrigues, Fernanda (McDonnell Genome Institute) ;
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Calinawan, Anna Pamela (Icahn School of Medicine at Mount Sinai) ;
Dhanasekaran, Saravana Mohan (University of Michigan) ;
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhou, Daniel Cui (McDonnell Genome Institute) ;
Wang, Liang-Bo (McDonnell Genome Institute) ;
Baral, Jessika (McDonnell Genome Institute) ;
Johnson, Jared L. (Weill Cornell Medicine) ;
Huntsman, Emily M. (Weill Cornell Medicine) ;
Pugliese, Pietro (University of Sannio (Benevento, Itàlia)) ;
Colaprico, Antonio (University of Miami Miller School of Medicine) ;
Iavarone, Antonio (University of Miami Miller School of Medicine) ;
Chheda, Milan G. (Washington University in St. Louis) ;
Ricketts, Christopher J. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Fenyö, David (NYU Grossman School of Medicine) ;
Payne, Samuel H. (Brigham Young University) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Gillette, Michael A. (Harvard Medical School) ;
Kumar-Sinha, Chandan (University of Michigan) ;
Lazar, Alexander (The University of Texas MD Anderson Cancer Center) ;
Cantley, Lewis (Weill Cornell Medicine) ;
Getz, Gad A. (Harvard Medical School) ;
Ding, Li (Siteman Cancer Center) ;
An, Eunkyung ;
Anurag, Meenakshi ;
Bavarva, Jasmin ;
Birrer, Michael J. ;
Ceccarelli, Michele ;
Chan, Daniel W. ;
Chinnaiyan, Arul M. ;
Cho, Hanbyul ;
Chowdhury, Shrabanti ;
Cieslik, Marcin P. ;
da Veiga Leprevost, Felipe ;
Day, Corbin ;
Domagalski, Marcin J. ;
Dou, Yongchao ;
Druker, Brian J. ;
Edwards, Nathan ;
Ellis, Matthew J. ;
Selvan, Myvizhi Esai ;
Foltz, Steven M. ;
Francis, Alicia ;
Gonzalez Robles, Tania J. ;
Gosline, Sara J. C. ;
Gümüş, Zeynep H. ;
Hiltke, Tara ;
Hong, Runyu ;
Hostetter, Galen ;
Hu, Yingwei ;
Huang, Chen ;
Huntsman, Emily ;
Jaehnig, Eric J. ;
Jewel, Scott D. ;
Ji, Jiayi ;
Jiang, Wen ;
Katsnelson, Lizabeth ;
Ketchum, Karen A. ;
Kolodziejczak, Iga ;
Lei, Jonathan T. ;
Liao, Yuxing ;
Lindgren, Caleb M. ;
Liu, Tao ;
Ma, Weiping ;
McKerrow, Wilson ;
Nesvizhskii, Alexey I. ;
Newton, Chelsea ;
Oldroyd, Robert ;
Omenn, Gilbert S. ;
Paulovich, Amanda G. ;
Petralia, Francesca ;
Reva, Boris ;
Rodland, Karin D. ;
Ruggles, Kelly V. ;
Rykunov, Dmitry ;
Savage, Sara R. ;
Schadt, Eric E. ;
Schnaubelt, Michael ;
Schraink, Tobias ;
Shi, Zhiao ;
Smith, Richard D. ;
Song, Xiaoyu ;
Tan, Jimin ;
Thangudu, Ratna R. ;
Tignor, Nicole ;
Wang, Joshua M. ;
Wang, Pei ;
Wang, Ying Cindy ;
Wen, Bo ;
Wiznerowicz, Maciej ;
Yi, Xinpei ;
Zhang, Bing ;
Zhang, Hui ;
Zhang, Xu ;
Zhang, Zhen ;
Universitat Autònoma de Barcelona
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. [...]
2023 -  10.1016/j.cell.2023.07.014
Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25
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39 p, 1.4 MB |
Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
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Radua, Joaquim (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Vieta, Eduard (Universitat de Barcelona) ;
Shinohara, Russell (Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA) ;
Kochunov, Peter (Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA) ;
Quidé, Yann (Neuroscience Research Australia, Sydney, NSW, Australia) ;
Green, Melissa J. (Neuroscience Research Australia, Sydney, NSW, Australia) ;
Weickert, Cynthia S. (Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, Newyork, NY, USA) ;
Weickert, Thomas (Neuroscience Research Australia, Sydney, NSW, Australia) ;
Bruggemann, Jason (Neuroscience Research Australia, Sydney, NSW, Australia) ;
Kircher, Tilo (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ;
Nenadić, Igor (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ;
Cairns, Murray J. (Hunter Medical Research Institute, Newcastle, NSW, Australia) ;
Seal, Marc (The University of Melbourne, Australia) ;
Schall, Ulrich (Hunter Medical Research Institute, Newcastle, NSW, Australia) ;
Henskens, Frans (Health Behaviour Research Group, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia) ;
Fullerton, Janice M. (Neuroscience Research Australia, Sydney, NSW, Australia) ;
Mowry, Bryan (Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia) ;
Pantelis, Christos (North Western Mental Health, Melbourne Health, Melbourne, VIC, Australia) ;
Lenroot, Rhoshel (University of New Mexico, Albuquerque, NM, USA) ;
Cropley, Vanessa (Melbourne Neuropsychiatry Centre, Dept. of Psychiatry, University of Melbourne, Melbourne, VIC, Australia) ;
Loughland, Carmel (University of Newcastle, Newcastle, NSW, Australia) ;
Scott, Rodney (University of Newcastle, Newcastle, NSW, Australia) ;
Wolf, Daniel H. (Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA) ;
Satterthwaite, Theodore D. (Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA) ;
Tan, Yunlong (Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China) ;
Sim, Kang (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore) ;
Piras, Fabrizio (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy) ;
Spalletta, Gianfranco (Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA) ;
Banaj, Nerisa (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy) ;
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation (Barcelona, Catalunya)) ;
Solanes, Aleix (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Albajes-Eizagirre, Anton (FIDMAG Germanes Hospitalàries Research Foundation (Barcelona, Catalunya)) ;
Canales-Rodriguez, Erick Jorge (Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland) ;
Sarro, Salvador (Universitat Internacional de Catalunya. Facultat de Medicina) ;
Giorgio, Annabella Di (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy) ;
Bertolino, Alessandro (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy) ;
Stäblein, Michael (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany) ;
Oertel, Viola (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany) ;
Knöchel, Christian (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany) ;
Borgwardt, Stefan (Department of Psychiatry and Psychotherapy, University Lübeck, Germany) ;
du Plessis, Stefan (University of Stellenbosch, Cape Town, Western Province, South Africa) ;
Yun, Je-Yeon (Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea) ;
Kwon, Jun Soo (Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea) ;
Dannlowski, Udo (Department of Psychiatry, University of Münster, Münster, Germany) ;
Hahn, Tim (Department of Psychiatry, University of Münster, Münster, Germany) ;
Grotegerd, Dominik (Department of Psychiatry, University of Münster, Münster, Germany) ;
Alloz, Clara (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Arango, Celso (Universidad Complutense de Madrid. Facultad de Medicina) ;
Janssen, Joost (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Díaz-Caneja, Covadonga (Universidad Complutense de Madrid. Facultad de Medicina) ;
Jiang, Wenhao (Georgia State University, Atlanta, GA, USA) ;
Calhoun, Vince (Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA) ;
Ehrlich, Stefan (Technische Universität Dresden, Faculty of Medicine, Division of Psychological and Social Medicine, Dresden, Germany) ;
Yang, Kun (Departments of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA) ;
Cascella, Nicola G. (Departments of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA) ;
Takayanagi, Yoichiro (Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA) ;
Sawa, Akira (Departments of Psychiatry, Neuroscience, and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA) ;
Tomyshev, Alexander (Mental Health Research Center, Moscow, Russia) ;
Lebedeva, Irina (Mental Health Research Center, Moscow, Russia) ;
Kaleda, Vasily (Mental Health Research Center, Moscow, Russia) ;
Kirschner, Matthias (Montreal Neurological Institute, McGill University, Montreal, Canada) ;
Hoschl, Cyril (Department of Psychiatry and Clinical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic) ;
Tomecek, David (Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic) ;
Skoch, Antonin (MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic) ;
van Amelsvoort, Therese (Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands) ;
Bakker, Geor (Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands) ;
James, Anthony (Oxford University. Department of Psychiatry) ;
Preda, Adrian (Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA) ;
Weideman, Andrea (Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA) ;
Stein, Dan J. (SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, Western Province, South Africa) ;
Howells, Fleur (Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa) ;
Uhlmann, Anne (Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden, Germany) ;
Temmingh, Henk (Valkenburg Hospital, Observatory, Cape Town, Western Cape, South Africa) ;
López-Jaramillo, Carlos (Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellin, Colombia) ;
Díaz-Zuluaga, Ana M.. (Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia) ;
Fortea, Lydia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martinez-Heras, Eloy (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Solana, Elisabeth (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llufriu, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jahanshad, Neda (Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA) ;
Thompson, Paul (Imaging Genetics Center, Department of Neurology, University of Southern California, Los Angeles, CA, USA) ;
Turner, Jessica (Georgia State University, Atlanta, GA, USA) ;
van Erp, Theo (Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, 92697, USA)
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. [...]
2020 - 10.1016/j.neuroimage.2020.116956
NeuroImage, Vol. 218 (may 2020) , p. 116956
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