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19 p, 1.2 MB Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer / Liu, Junke (University of Science and Technology, Wuhan, China) ; Zhang, Zongyong (University of Science and Technology, Wuhan, China) ; Moreno-Delgado, David (Université de Montpellier, France) ; Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira, Xavier (Université de Montpellier, France) ; Trapero, Ana (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Goudet, Cyril (Université de Montpellier, France) ; Llebaria, Amadeu (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yuan, Qilin (University of Science and Technology, Wuhan, China) ; Rondard, Philippe (Université de Montpellier, France) ; Huang, Siluo (University of Science and Technology, Wuhan, China) ; Liu, Jianfeng (University of Science and Technology, Wuhan, China) ; Pin, Jean-Philippe (Université de Montpellier, France) ; Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. [...]
2017 - 10.7554/eLife.26985
eLife, Vol. 6 (august 2017)  
Detailed record - Creative Commons

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