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11 p, 1.4 MB |
Prognostic gene expression signature for high-grade serous ovarian cancer
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Millstein, Joshua (University of Southern California) ;
Budden, Timothy (The University of Manchester) ;
Goode, Ellen L. (Mayo Clinic) ;
Anglesio, Michael (University of British Columbia) ;
Talhouk, Aline (University of British Columbia) ;
Intermaggio, Maria Paola (University of NSW Sydney) ;
Leong, Hueisan (Peter MacCallum Cancer Center) ;
Chen, Stephanie S. (Cedars-Sinai Medical Center) ;
Elatre, Wafaa A. (University of Southern California) ;
Gilks, Cyril Blake (University of British Columbia) ;
Nazeran, Tayyebeh M. (University of British Columbia) ;
Volchek, Mila (Royal Women's Hospital) ;
Bentley, Rex C. (Duke University Hospital) ;
Wang, Chen (Mayo Clinic) ;
Chiu, Derek S. (University of British Columbia) ;
Kommoss, Stefan (Tuebingen University Hospital) ;
Leung, Samuel C. Y. (University of British Columbia) ;
Senz, Janine (University of British Columbia) ;
Lum, Amy (University of British Columbia) ;
Chow, Veronica (University of British Columbia) ;
Sudderuddin, Hanwei (University of British Columbia) ;
Mackenzie, Robertson (University of British Columbia) ;
George, Joshy (The Jackson Laboratory for Genomic Medicine) ;
Fereday, Sian (University of Melbourne) ;
Hendley, Joy (University of Melbourne) ;
Traficante, Nadia (University of Melbourne) ;
Steed, Helen (Royal Alexandra Hospital) ;
Koziak, Jennifer M. (Alberta Health Services-Cancer Care) ;
Köbel, Martin (Foothills Medical Center) ;
McNeish, Iain (University of Glasgow) ;
Goranova, Teodora Evgenieva (University of Cambridge) ;
Ennis, Darren P. (University of Glasgow) ;
Macintyre, Geoff (University of Cambridge) ;
Silva De Silva, D. (University of Cambridge) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
García Donas, J. (HM Hospitales D Centro Integral Oncológico HM Clara Campal) ;
Hernando, Susana (Hospital Universitario Funcacion Alcorcon) ;
Rodriguez, Gustavo C. (University of Chicago) ;
Cushing-Haugen, Kara L. (Fred Hutchinson Cancer Research Center) ;
Harris, Holly Ruth (University of Washington) ;
Greene, Casey S. (University of Pennsylvania) ;
Zelaya, René A. (Geisel School of Medicine at Dartmouth) ;
Behrens, Sabine (German Cancer Research Center (DKFZ)) ;
Fortner, Renée T. (German Cancer Research Center (DKFZ)) ;
Sinn, Hans-Peter (Heidelberg University Hospital (Alemanya)) ;
Herpel, Esther (University Hospital and German Cancer Research Center) ;
Lester, Jenny (Cedars-Sinai Medical Center) ;
Lubinski, Jan (Pomeranian Medical University) ;
Oszurek, Oleg (Pomeranian Medical University) ;
Tołoczko, Aleksandra D. (Pomeranian Medical University) ;
Cybulski, Cezary (Pomeranian Medical University) ;
Menkiszak, Janusz Leszek (Pomeranian Medical University) ;
Pearce, Celeste Leigh (University of Southern California Norris Comprehensive Cancer Center) ;
Pike, Malcolm C. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ;
Tseng, Chiuchen Cheng (University of Southern California) ;
Alsop, Jennifer (University of Cambridge) ;
Rhenius, Valerie (University of Cambridge) ;
Song, Hongan (University of Cambridge) ;
Jimenez-Liñan, Mercedes (Addenbrooke's Hospital NHS Trust) ;
Piskorz, Anna M. (University of Cambridge) ;
Gentry-Maharaj, Aleksandra (University College London) ;
Karpinskyj, Chloe (University College London) ;
Widschwendter, M. (University College London) ;
Singh, Naveena K. (Barts Health National Health Service Trust) ;
Kennedy, Catherine J. (Westmead Hospital) ;
Harnett, Paul R. (University of Sidney) ;
Gao, Bo (Westmead Hospital) ;
Johnatty, Sharon E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Sayer, Robyn A. (Westmead Hospital) ;
Boros, Jessica (Westmead Hospital) ;
Winham, Stacey J. (Mayo Clinic) ;
Keeney, Gary L. (Mayo Clinic) ;
Kaufmann, Scott H. (Mayo Clinic) ;
Larson, Melissa C. (Mayo Clinic) ;
Luk, Hugh W. (University of Hawaii Cancer Center) ;
Hernandez, Brenda Y. (University of Hawaii Cancer Center) ;
Thompson, Pamela J. (Cedars-Sinai Medical Center) ;
Wilkens, Lynne Ross (University of Hawaii Cancer Center) ;
Carney, Michael E. (University of Hawaii) ;
Trabert, Britton (National Cancer Institute) ;
Lissowska, Jolanta (M Sklodowska Curie National Research Institute of Oncology) ;
Brinton, Louise Annette (National Cancer Institute) ;
Sherman, Mark E. (Mayo Clinic College of Medicine) ;
Bodelón, Clara (National Cancer Institute) ;
Hinsley, Samantha (University of Glasgow) ;
Lewsley, Liz Anne (University of Glasgow) ;
Glasspool, Rosalind M. (University of Glasgow) ;
Banerjee, Susana (The Royal Marsden NHS Foundation Trust and Institute of Cancer Research) ;
Stronach, Euan A. (Imperial College London) ;
Haluska, Paul J. (Mayo Clinic) ;
Ray-Coquard, Isabelle Laure (Centre Leon Berard and University Claude Bernard Lyon 1) ;
Mahner, Sven (LMU Munich) ;
Winterhoff, Boris J. N. (University of Minnesota) ;
Slamon, Dennis J. (University of California at Los Angeles) ;
Levine, Douglas A. (NYU Langone Medical Center) ;
Kelemen, Linda E. (Medical University of South Carolina) ;
Benitez, Javier J. (Centro Nacional de Investigaciones Oncológicas) ;
Chang-Claude, J. (University Medical Center Hamburg-Eppendorf) ;
Gronwald, Jacek (Pomeranian Medical University) ;
Wu, Anna H. (University of Southern California) ;
Menon, Usha (MRC University College London) ;
Goodman, Marc T. (Cedars-Sinai Medical Center) ;
Schildkraut, Joellen M. (Emory University) ;
Wentzensen, Nicolas A. (National Cancer Institute) ;
Brown, Robert (Imperial College London) ;
Berchuck, Andrew (Duke University Hospital) ;
Gayther, Simon A. (Cedars-Sinai Medical Center) ;
García, M. J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Henderson, Michelle J. (University of NSW Sydney) ;
Rossing, Mary Anne (University of Washington) ;
Beeghly-Fadiel, Alicia (Vanderbilt University School of Medicine) ;
Fasching, Peter Andreas (Friedrich-Alexander-University Erlangen-Nuremberg) ;
Orsulic, Sandra (Cedars-Sinai Medical Center) ;
Karlan, Beth Y. (Cedars-Sinai Medical Center) ;
Konecny, Gottfried Ewald (University of California at Los Angeles) ;
Huntsman, David G. (BC Cancer Research Centre) ;
Brenton, James D. (University of Cambridge) ;
Doherty, Jennifer Anne (University of Utah) ;
Pharoah, Paul D. P. (University of Cambridge) ;
Ramus, Susan (University of NSW Sydney) ;
Universitat Autònoma de Barcelona
Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. [...]
2020 -  10.1016/j.annonc.2020.05.019
Annals of oncology, Vol. 31 Núm. 9 (01 2020) , p. 1240-1250
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12 p, 1.2 MB |
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
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Gao, Yixin (Xuzhou Medical University) ;
Wang, Ting (Xuzhou Medical University) ;
Yu, Xinghao (Xuzhou Medical University) ;
Ferrari, Raffaele (Russell Square House) ;
Hernandez, Dena G. (Queen Square) ;
Nalls, Michael A. (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ;
Rohrer, Jonathan D. (Queen Square) ;
Ramasamy, Adaikalavan (University of Oxford) ;
Kwok, John B.J. (University of New South Wales) ;
Dobson-Stone, Carol (University of New South Wales) ;
Brooks, William S. (University of New South Wales) ;
Schofield, Peter R. (Neuroscience Research Australia) ;
Halliday, Glenda M. (Neuroscience Research Australia) ;
Hodges, John R. (Neuroscience Research Australia) ;
Piguet, Olivier (Neuroscience Research Australia) ;
Bartley, Lauren (Neuroscience Research Australia) ;
Thompson, Elizabeth (University of Adelaide) ;
Haan, Eric (University of Adelaide) ;
Hernández, Isabel (Institut Català de Neurociéncies Aplicades) ;
Ruiz, Agustín (Institut Català de Neurociéncies Aplicades) ;
Boada, Mercè (Institut Català de Neurociéncies Aplicades) ;
Borroni, Barbara (University of Brescia) ;
Padovani, Alessandro (University of Brescia) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Cairns, Nigel J. (Washington University) ;
Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Forloni, Gianluigi (IRCCS Istituto di Ricerche Farmacologiche. "Mario Negri") ;
Albani, Diego (IRCCS Istituto di Ricerche Farmacologiche. "Mario Negri") ;
Galimberti, Daniela (IRCCS Ospedale Maggiore Policlinico) ;
Fenoglio, Chiara (IRCCS Ospedale Maggiore Policlinico) ;
Serpente, Maria (IRCCS Ospedale Maggiore Policlinico) ;
Scarpini, Elio (University of Milan) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Waldö, Maria Landqvist (Lund University) ;
Nilsson, Karin (Lund University) ;
Nilsson, Christer (Lund University) ;
Mackenzie, Ian R.A. (University of British Columbia) ;
Hsiung, Ging-Yuek R. (University of British Columbia) ;
Mann, David M. A. (Salford Royal Hospital) ;
Grafman, Jordan (Northwestern University) ;
Morris, Christopher M. (Newcastle University) ;
Attems, Johannes (Newcastle University) ;
Griffiths, Timothy D. (Newcastle University Medical School) ;
McKeith, Ian G. (Newcastle University) ;
Thomas, Alan J. (Newcastle University) ;
Pietrini, Pietro (IMT School for Advanced Studies) ;
Huey, Edward D. (Columbia University) ;
Wassermann, Eric M. (National Insititutes of Health) ;
Baborie, Atik (University of Alberta Edmonton) ;
Jaros, Evelyn (Newcastle University) ;
Tierney, Michael C. (National Insititutes of Health) ;
Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Razquin, Cristina (Universidad de Navarra) ;
Ortega-Cubero, Sara (Universidad de Navarra) ;
Alonso, Elena (Universidad de Navarra) ;
Perneczky, Robert (West London Mental Health Trust) ;
Diehl-Schmid, Janine (Technische Universität München) ;
Alexopoulos, Panagiotis (Technische Universität München) ;
Kurz, Alexander (Technische Universität München) ;
Rainero, Innocenzo (A.O. Città della Salute e della Scienza di Torino) ;
Rubino, Elisa (A.O. Città della Salute e della Scienza di Torino) ;
Pinessi, Lorenzo (A.O. Città della Salute e della Scienza di Torino) ;
Rogaeva, Ekaterina (University of Toronto) ;
St George Hyslop, Peter (University of Cambridge) ;
Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Rowe, James B. (Behavioural and Clinical Neuroscience Institute) ;
Schlachetzki, Johannes C. M. (University of California San Diego) ;
Uphill, James (University College London. Institute of Neurology) ;
Collinge, John (University College London. Institute of Neurology) ;
Mead, Simon (University College London. Institute of Neurology) ;
Danek, Adrian (German Center for Neurodegenerative Diseases (DZNE)) ;
Van Deerlin, Vivianna M. (University of Pennsylvania Perelman School of Medicine) ;
Grossman, Murray (University of Pennsylvania Perelman School of Medicine) ;
Trojanowski, John Q. (University of Pennsylvania Perelman School of Medicine) ;
van der Zee, Julie (University of Antwerp) ;
Cruts, Marc (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Cappa, Stefano F. (Vita-Salute University and San Raffaele Scientific Institute) ;
Leber, Isabelle (CNRS UMR 7225) ;
Hannequin, Didier (Rouen University Hospital (França)) ;
Golfier, Véronique (CH Saint Brieuc) ;
Vercelletto, Martine (CHU Nantes) ;
Brice, Alexis (AP-HP. Hôpital de la Salpêtrière) ;
Nacmias, Benedetta (University of Florence) ;
Sorbi, Sandro (University of Florence and IRCCS "Don Carlo Gnocchi" Firenze) ;
Bagnoli, Silvia (University of Florence) ;
Piaceri, Irene (University of Florence) ;
Nielsen, Jørgen E. (Copenhagen University Hospital) ;
Hjermind, Lena E. (University of Copenhagen) ;
Riemenschneider, Matthias (Saarland University) ;
Mayhaus, Manuel (Saarland University) ;
Ibach, Bernd (University Regensburg) ;
Gasparoni, Gilles (Saarland University) ;
Pichler, Sabrina (Saarland University) ;
Gu, Wei (University of Luxembourg) ;
Rossor, Martin N. (Queen Square) ;
Fox, Nick C. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ;
Warren, Jason D. (Queen Square) ;
Spillantini, Maria Grazia (University of Cambridge) ;
Morris, Huw R. (Russell Square House) ;
Rizzu, Patrizia (German Center for Neurodegenerative Diseases-Tübingen) ;
Heutink, Peter (German Center for Neurodegenerative Diseases-Tübingen) ;
Snowden, Julie S. (University of Manchester) ;
Rollinson, Sara (University of Manchester) ;
Richardson, Anna (University of Manchester) ;
Gerhard, Alexander (The University of Manchester) ;
Bruni, Amalia C. (ASPCZ) ;
Maletta, Raffaele (ASPCZ) ;
Frangipane, Francesca (ASPCZ) ;
Cupidi, Chiara (ASPCZ) ;
Bernardi, Livia (ASPCZ) ;
Anfossi, Maria (ASPCZ) ;
Gallo, Maura (ASPCZ) ;
Conidi, Maria Elena (ASPCZ) ;
Smirne, Nicoletta (ASPCZ) ;
Rademakers, Rosa (Mayo Clinic Jacksonville) ;
Baker, Matt (Mayo Clinic Jacksonville) ;
Dickson, Dennis W. (Mayo Clinic Jacksonville) ;
Graff-Radford, Neill R. (Mayo Clinic Jacksonville) ;
Petersen, Ronald C. (Mayo Clinic Rochester) ;
Knopman, David (Mayo Clinic Rochester) ;
Josephs, Keith A. (Mayo Clinic Rochester) ;
Boeve, Bradley (Mayo Clinic Rochester) ;
Parisi, Joseph E. (Mayo Clinic Rochester) ;
Seeley, William W. (University of California) ;
Miller, Bruce L. (University of California) ;
Karydas, Anna M. (University of California) ;
Rosen, Howard (University of California) ;
van Swieten, John C. (VU University Medical Centre) ;
Dopper, Elise G. P. (Erasmus Medical Centre) ;
Seelaar, Harro (Erasmus Medical Centre) ;
Pijnenburg, Yolande A. L. (VU University Medical Centre) ;
Scheltens, Philip (VU University Medical Centre) ;
Logroscino, Giancarlo (University of Bari) ;
Capozzo, Rosa (University of Bari) ;
Novelli, Valeria (Fondazione Policlinico Universitario A. Gemelli) ;
Puca, Annibale A. (University of Salerno) ;
Franceschi, Massimo (IRCCS Multimedica) ;
Postiglione, Alfredo (University of Naples Federico II) ;
Milan, Graziella (Geriatric Center Frullone- ASL Napoli 1 Centro) ;
Sorrentino, Paolo (Geriatric Center Frullone- ASL Napoli 1 Centro) ;
Kristiansen, Mark (Institute of Child Health (ICH)) ;
Chiang, Huei-Hsin (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Pasquier, Florence (Univ Lille) ;
Rollin, Adeline (Univ Lille) ;
Deramecourt, Vincent (Univ Lille) ;
Lebouvier, Thibaud (Univ Lille) ;
Kapogiannis, Dimitrios (National Institute on Aging (NIA/NIH)) ;
Ferrucci, Luigi (National Institute on Aging (Baltimore, Estats Units d'Amèrica)) ;
Pickering-Brown, S. (University of Manchester) ;
Singleton, Andrew B. (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ;
Hardy, John (Russell Square House) ;
Momeni, Parastoo (Texas Tech University Health Science Center) ;
Zhao, Huashuo (Xuzhou Medical University) ;
Zeng, Ping (Xuzhou Medical University) ;
Universitat Autònoma de Barcelona
We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). [...]
2020 - 10.1038/s41598-020-68848-9
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 12184
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7 p, 599.3 KB |
Fish can show emotional fever : stress-induced hyperthermia in zebrafish
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Rey i Planellas, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huntingford, Felicity A. (University of Stirling. School of Natural Sciences) ;
Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vargas, Reynaldo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Knowles, Toby G. (University of Bristol. School of Veterinary Science) ;
Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Whether fishes are sentient beings remains an unresolved and controversial question. Among characteristics thought to reflect a low level of sentience in fishes is an inability to show stress-induced hyperthermia (SIH), a transient rise in body temperature shown in response to a variety of stressors. [...]
2015 - 10.1098/rspb.2015.2266
Proceedings of the Royal Society B: Biological Sciences, Vol. 282, issue 1819 (Nov. 2015) , art. 20152266
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11 p, 1.2 MB |
Behavioural fever is a synergic signal amplifying the innate immune response
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Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rey i Planellas, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vargas, Reynaldo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huerta Casado, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huntingford, Felicity A. (University of Glasgow) ;
Goetz, Frederick William (Northwest Fisheries Science Centre (Seattle, USA)) ;
Moore, Janice (Colorado State University. Biology Department) ;
Garcia Valtanen, Pablo (Universidad Miguel Hernández de Elche) ;
Estepa, Amparo (Universidad Miguel Hernández de Elche) ;
Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Behavioural fever, defined as an acute change in thermal preference driven by pathogen recognition, has been reported in a variety of invertebrates and ectothermic vertebrates. It has been suggested, but so far not confirmed, that such changes in thermal regime favour the immune response and thus promote survival. [...]
2013 - 10.1098/rspb.2013.1381
Proceedings of the Royal Society B: Biological Sciences, Vol. 280 (Sep. 2013) , art. 20131381
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5 p, 149.8 KB |
Screening for Coping Style Increases the Power of Gene Expression Studies
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Mackenzie, Simon (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ribas Cabezas, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pilarczyk, Maciej (Polska Akademia Nauk, Zakład Ichtiobiologii i Gospodarki Rybackiej, Zaborze) ;
Morera, Davinia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kadri, Sunil (University of Glasgow) ;
Huntingford, Felicity A. (University of Glasgow)
Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges. This is clearly illustrated by a study in which common carp displaying behavioural predictors of different coping styles (characterised by a proactive, adrenaline-based or a reactive, cortisol-based response) were subjected to inflammatory challenge and specific gene transcripts measured in individual brains. [...]
2009 - 10.1371/journal.pone.0005314
PloS one, Vol. 4, Issue 4 (April 2009) , art. e5314
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