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UAB Digital Repository of Documents 2 records found  Search took 0.03 seconds. 
1.
54 p, 61.9 MB Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors / Cordón Barris, Lluís (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pascual-Guiral, Sònia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yang, Shaobin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lope-Piedrafita, Silvia (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Niemeyer, Carlota (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Claro Izaguirre, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The phosphoinositide 3-kinase (PI 3-kinase)/Akt signaling pathway plays essential roles during neuronal development. The 3-phosphoinositide-dependent protein kinase 1 (PDK1) coordinates the PI 3-kinase signals by activating twenty three kinases of the AGC family including Akt. [...]
2016 - 10.1128/MCB.00230-16
Molecular and cellular biology, Vol. 36, Num. 23 (December 2016) , p. 2967-2982  
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2.
17 p, 1.0 MB Molecular dissection of a yeast septin : distinct domains are required for septin interaction, localization, and function / Casamayor Gracia, Antonio ; Snyder, Michael (Yale University. Department of Mollecular, Cellular and Development Biology)
The septins are a family of cytoskeletal proteins present in animal and fungal cells. They were first identified for their essential role in cytokinesis, but more recently, they have been found to play an important role in many cellular processes, including bud site selection, chitin deposition, cell compartmentalization, and exocytosis. [...]
2003 - 10.1128/MCB.23.8.2762-2777.2003
Molecular and cellular biology, Vol. 23, Num. 8 (2003) , p. 2762-2777  
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