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1.
11 p, 649.8 KB Peripheral effects of morphine and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain : nitric oxide signaling / Hervera Abad, Arnau (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Negrete, Roger (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Martín-Campos, Jesús M. (Institut d'Investigació Biomèdica Sant Pau) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona
Background: The local administration of μ-opioid receptor (MOR) agonists attenuates neuropathic pain but the precise mechanism implicated in this effect is not completely elucidated. We investigated if nitric oxide synthesized by neuronal (NOS1) or inducible (NOS2) nitric oxide synthases could modulate the local antiallodynic effects of morphine through the peripheral nitric oxide-cGMP-protein kinase G (PKG)-ATP-sensitive K+ (KATP) channels signaling pathway activation and affect the dorsal root ganglia MOR expression during neuropathic pain. [...]
2011 - 10.1186/1744-8069-7-25
Molecular pain, Vol. 7, N. 25 (April 2011) , p. 1-11  
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2.
16 p, 1.6 MB Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse / Manassero, Giusi (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Repetto, Ivan E. (Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (Torí, Itàlia)) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valsecchi, Valeria (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Bonny, Christophe (Lausanne University Hospital) ; Rossi, Ferdinando (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Vercelli, Alessandro (University of Turin. Department of Neuroscience (Torí, Itàlia))
Background: Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JNK) activity in cells of the dorsal root ganglia (DRGs) and spinal cord is involved in triggering neuropathic pain. [...]
2012 - 10.1186/1744-8069-8-39
Molecular pain, Vol. 8, N. 39 (May 2012) , p. 1-16
3 documents
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