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11 p, 618.2 KB |
Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities : Laboratory tools for an early and differential diagnosis
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Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Fernández, Sara (Hospital Clínic i Provincial de Barcelona) ;
Ventosa, Helena (Hospital Clínic i Provincial de Barcelona) ;
Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramos, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ;
Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ;
Fernández De Larrea, Carlos (Hospital Clínic i Provincial de Barcelona) ;
Urbano-Ispizua, Alvaro (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Charité Universitätsmedizin Berlin, Germany) ;
Nicolás, J.M. (Hospital Clínic i Provincial de Barcelona) ;
Téllez, Adrian (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Avilés, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Castro Rebollo, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Background Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated neurotoxicity syndromes are life-threatening toxicities in which the endothelium could be a pathophysiological substrate. [...]
2023 -  10.1136/jitc-2022-006365
Journal for immunotherapy of cancer, Vol. 11 Núm. 4 (april 2023)
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12 p, 1.6 MB |
Antithrombotic and prohemorrhagic actions of different concentrations of apixaban in patients exposed to single and dual antiplatelet regimens
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castrillo, Leticia (Hospital Clínic i Provincial de Barcelona) ;
Jerez, Didac (Hospital Clínic i Provincial de Barcelona) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Mendieta, Guiomar (Hospital Clínic i Provincial de Barcelona) ;
Zafar, M.Urooj (Icahn School of Medicine at Mount Sinai, New York, USA.) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Sanchez, Pablo (Institut de Ciències del Mar) ;
Badimon, Juan Jose (Icahn School of Medicine at Mount Sinai, New York, USA) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Roqué, Mercè (Hospital Clínic i Provincial de Barcelona)
We evaluated modifications in the hemostatic balance of different concentrations of apixaban (APIX) in 25 healthy donors and 53 patients treated with aspirin (ASA, n = 21), ASA and clopidogrel (ASA + CLOPI, n = 11), or ASA and ticagrelor (ASA + TICA, n = 21). [...]
2023 - 10.1038/s41598-023-50347-2
Scientific reports, Vol. 13 Núm. 1 (december 2023)
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12 p, 7.7 MB |
Differential protein expression in endothelial cells exposed to serum from patients with acute graft-vs-host disease, depending on steroid response
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Universität zu Berlin, Germany) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Graft-versus-host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury is crucial as pathophysiological substrate for GVHD. GVHD first-line treatment is high-dose corticosteroids, although some patients are steroid-refractory. [...]
2023 - 10.1111/jcmm.17712
Journal of Cellular and Molecular Medicine, Vol. 27 Núm. 9 (may 2023) , p. 1227-1238
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16 p, 1.1 MB |
Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications
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Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Salas, María Queralt (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Escribano-Serrat, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guillen-Olmos, Elena (Hospital Clínic i Provincial de Barcelona) ;
Fernandez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Ventosa-Capell, Helena (Hospital Clínic i Provincial de Barcelona) ;
Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Nomdedeu, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
De Moner, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humoral factors, and to all those elements (biological, chemical, or hemodynamic) that circulate in blood at a certain time. [...]
2023 - 10.3389/fmed.2023.1285898
Frontiers in Medicine, Vol. 10 (2023) , p. 1285898
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17 p, 2.0 MB |
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy
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Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Youssef, Lina (BCNatal (Hospital Clínic and Hospital Sant Joan de Déu)) ;
Ramos, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bonastre, Laura (Hospital Clínic i Provincial de Barcelona) ;
Pino, Marc (Hospital Clínic i Provincial de Barcelona) ;
Gomez-Ramirez, Pilar (Hospital Clínic i Provincial de Barcelona) ;
Martin, Lidia (Hospital Clínic i Provincial de Barcelona) ;
Garcia Mateos, Estefania (Hospital Clínic i Provincial de Barcelona) ;
Sanchez, Pablo (Institut de Ciències del Mar) ;
Fernandez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Crovetto, Francesca (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Ginés (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro Rebollo, Pedro (Universitat de Barcelona) ;
Gratacos, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Crispi, Fatima (Hospital Clínic i Provincial de Barcelona) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Background: COVID-19 presents a spectrum of signs and symptoms in pregnant women that might resemble preeclampsia. Differentiation between severe COVID-19 and preeclampsia is difficult in some cases. [...]
2022 - 10.1016/j.ajog.2022.03.048
American Journal of Obstetrics and Gynecology, Vol. 227 Núm. 2 (august 2022)
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21 p, 257.6 KB |
Domains, ranges and strategy-proofness : the case of single-dipped preferences
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Barberà, Salvador 1946- (Universitat Autònoma de Barcelona) ;
Berga, Dolors (Universitat de Girona) ;
Moreno, Bernardo (Campus de El Ejido) ;
MOVE- Markets, Organizations and Votes in Economics
We characterize the set of all individual and group strategy-proof rules on the domain of all single-dipped preferences on a line. For rules defined on this domain, and on several of its subdomains, we explore the implications of these strategy-proofness requirements on the maximum size of the rules' range. [...]
Barcelona Barcelona School of Economics, 2009 (BSE working paper ; 418)
BSE Barcelona School of Economics Working Papers, 2009
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