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11.
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26 p, 2.9 MB |
Structure-guided mutations in the terminal organelle protein MG491 cause major motility and morphologic alterations on mycoplasma genitalium
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Martinelli, Luca (Institut de Biologia Molecular de Barcelona) ;
Garcia-Morales, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fita, Ignacio (Institut de Biologia Molecular de Barcelona) ;
Calisto, Bárbara Luísa Machado (Universidade do Porto. Instituto de Biologia Molecular e Celular)
The emergent human pathogen Mycoplasma genitalium, with one of the smallest genomes among cells capable of growing in axenic cultures, presents a flask-shaped morphology due to a protrusion of the cell membrane, known as the terminal organelle, that is involved in cell adhesion and motility and is an important virulence factor of this microorganism. [...]
2016 -  10.1371/journal.ppat.1005533
PLOS pathogens, Vol. 12 issue 4 (2016) , art. e1005533
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12.
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14 p, 1.6 MB |
A trigger enzyme in mycoplasma pneumoniae : impact of the glycerophosphodiesterase glpq on virulence and gene expression
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Schmidl, Sebastian R. (Georg-August-University Göttingen. Department of General Microbiology) ;
Otto, Andreas (Ernst-Moritz-Arndt-Universität Greifswald. Institut für Mikrobiologie und Molekularbiologie) ;
Lluch Senar, Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Busse, Julia (Georg-August-University Göttingen. Department of General Microbiology) ;
Becher, Dörte (Ernst-Moritz-Arndt-Universität Greifswald. Institut für Mikrobiologie und Molekularbiologie) ;
Stülke, Jörg (Georg-August-University Göttingen. Department of General Microbiology)
Mycoplasma pneumoniae is a causative agent of atypical pneumonia. The formation of hydrogen peroxide, a product of glycerol metabolism, is essential for host cell cytotoxicity. Phosphatidylcholine is the major carbon source available on lung epithelia, and its utilization requires the cleavage of deacylated phospholipids to glycerol-3-phosphate and choline. [...]
2011 - 10.1371/journal.ppat.1002263
PLOS pathogens, Vol. 7 issue 9 (2011) , art. e1002263
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13.
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23 p, 3.0 MB |
Latency reversal agents affect differently the latent reservoir present in distinct CD4+ t subpopulations
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Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribera, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badía, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martin-Castillo, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández-Sojo, Jesús (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in distinct subpopulations of cells is currently unknown. [...]
2019 - 10.1371/journal.ppat.1007991
PLOS pathogens, Vol. 15 Núm. 8 (august 2019) , p. e1007991
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14.
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33 p, 2.7 MB |
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
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Eraña, Hasier (ATLAS Molecular Pharma S. L.) ;
Charco, Jorge M. (CIC bioGUNE) ;
Di Bari, Michele Angelo (CIC bioGUNE) ;
Díaz-Domínguez, Carlos M. (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
López-Moreno, R. (CIC bioGUNE) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
González-Miranda, E. (CIC bioGUNE) ;
Pérez-Castro, Miguel A. (CIC bioGUNE) ;
García-Martínez, Sandra (ATLAS Molecular Pharma S. L.) ;
Bravo Lopez, Susana Belén (Proteomics Lab. IDIS) ;
Fernández-Borges, Natalia (CIC bioGUNE) ;
Geijo, Maria V. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
D'Agostino, C. (Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità) ;
Garrido, Joseba M (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
Bian, J. (Colorado State University. Prion Research Center (PRC).) ;
König, A. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Uluca-Yazgi, B. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Sabate, R. (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ;
Khaychuk, V. (Colorado State University. Prion Research Center (PRC).) ;
Vanni, Ilaria (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Telling, G. C. (Colorado State University. Prion Research Center (PRC).) ;
Heise, Henrike (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Nonno, Romolo (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Requena, Jesús R (Universidade de Santiago de Compostela) ;
Castilla, Joaquín (IKERBasque. Basque Foundation for Science)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. [...]
2019 - 10.1371/journal.ppat.1008117
PLOS pathogens, Vol. 15 Núm. 10 (2019) , p. e1008117
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15.
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12 p, 2.4 MB |
The Risk of sustained sexual transmission of Zika is underestimated
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Allard, Antoine (Centre de Recerca Matemàtica) ;
Althouse, Benjamin M. (New Mexico State University) ;
Hébert-Dufresne, Laurent (University of Vermont) ;
Scarpino, Samuel V. (Northeastern University (Boston, Mass.))
Pathogens often follow more than one transmission route during outbreaks-from needle sharing plus sexual transmission of HIV to small droplet aerosol plus fomite transmission of influenza. Thus, controlling an infectious disease outbreak often requires characterizing the risk associated with multiple mechanisms of transmission. [...]
2017 - 10.1371/journal.ppat.1006633
PLOS pathogens, Vol. 13, issue 9 (Sep. 2017) , e1006633
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16.
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17.
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20 p, 1.6 MB |
PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia
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Peligero, Cristina (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Argilaguet, Jordi 1977- (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Güerri-Fernández, Robert (Parc de Salut Mar. Unitat de Malalties Infeccioses) ;
Torres, Berta (Hospital Clínic i Provincial de Barcelona) ;
Ligero, Carmen (Hospital Clínic i Provincial de Barcelona) ;
Colomer, Pilar (Parc de Salut Mar. Unitat de Malalties Infeccioses) ;
Plana, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Knobel Freud, Hernando (Parc de Salut Mar. Unitat de Malalties Infeccioses) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Blocking the PD-1/PD-L1 pathway has emerged as a potential therapy to restore impaired immune responses in human immunodeficiency virus (HIV)-infected individuals. Most reports have studied the impact of the PD-L1 blockade on effector cells and neglected possible effects on regulatory T cells (Treg cells), which play an essential role in balancing immunopathology and antiviral effector responses. [...]
2015 - 10.1371/journal.ppat.1005270
PLOS pathogens, Vol. 11 (december 2015)
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18.
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9 p, 915.2 KB |
HIV-1 Capture and Transmission by Dendritic Cells : The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
McLaren, Paul J. (Lausanne University Hospital) ;
Telenti, Amalio (Lausanne University Hospital) ;
Kräusslich, Hans-Georg (Universitätsklinikum Heidelberg. Department of Infectious Diseases, Virology) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. [...]
2014 - 10.1371/journal.ppat.1004146
PLOS pathogens, Vol. 10 (july 2014)
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19.
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11 p, 527.4 KB |
Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART
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Buzón, Maria José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codoñer, Francisco M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Frost, Simon D. W. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Stevenson, Mario (University of Miami Miller School of Medicine, Miami, Florida, United States of America) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
In order to design strategies for eradication of HIV-1 from infected individuals, detailed insight into the HIV-1 reservoirs that persist in patients on suppressive antiretroviral therapy (ART) is required. [...]
2011 - 10.1371/journal.ppat.1002314
PLOS pathogens, Vol. 7 (october 2011)
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20.
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13 p, 954.1 KB |
Viral protein inhibits RISC activity by argonaute binding through conserved WG/GW motifs
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Giner, Ana (Centre de Recerca en Agrigenòmica) ;
Lakatos, Lóránt (Agricultural Biotechnology Center (Hungria)) ;
Garcia i Chapa, Meritxell (Centre de Recerca en Agrigenòmica) ;
Lopez-Moya, Juan Jose (Centre de Recerca en Agrigenòmica) ;
Burgyán, József (Agricultural Biotechnology Center (Hungria))
RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. [...]
2010 - 10.1371/journal.ppat.1000996
Plos pathogens, Vol. 6, no. 7 (July 2010) , e1000996
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