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9 p, 1.6 MB |
Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab
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Trilla-Fuertes, Lucía (Biomedica Molecular Medicine (Madrid)) ;
Gámez-Pozo, Angelo (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Maurel, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Carbonero, Rocío (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
G-Pastrián, Laura (Hospital Universitario La Paz (Madrid)) ;
Mendiola, Marta (Centro de Investigación Biomédica en Red de Cáncer) ;
Peña, Cristina (Hospital Universitario La Paz (Madrid)) ;
López-Vacas, Rocío (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ;
García-Alfonso, Pilar (Hospital General Universitario Gregorio Marañón) ;
Ramos-Ruiz, Ricardo (Genomics Unit Cantoblanco) ;
Llorens, Carlos (Biotechvana SL (Madrid)) ;
Ghanem, Ismael (Hospital Universitario La Paz (Madrid)) ;
Conill, Carles (Hospital Clínic i Provincial de Barcelona) ;
Heredia Soto, Victoria (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Campos-Barros, Ángel (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Fresno Vara, Juan Ángel (Centro de Investigación Biomédica en Red de Cáncer) ;
Feliu, Jaime (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Squamous cell carcinoma is the most frequent histologic type of anal carcinoma. The standard of care since the 1970s has been a combination of 5-fluorouracil, mitomycin C, and radiotherapy. This treatment is very effective in T1/T2 tumors (achieving complete regression in 80-90% of tumors). [...]
2021 -  10.1038/s41598-021-86966-w
Scientific reports, Vol. 11 (april 2021)
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6 p, 1.2 MB |
Global ensemble projections reveal trophic amplification of ocean biomass declines with climate change
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Lotze, Heike K.. (Dalhousie University. Department of Biology) ;
Tittensor, Derek P. (Dalhousie University. Department of Biology) ;
Bryndum-Buchholz, Andrea (Dalhousie University. Department of Biology) ;
Eddy, Tyler D. (Dalhousie University. Department of Biology) ;
Cheung, William W. L. (University of British Columbia. Institute for the Oceans and Fisheries) ;
Galbraith, Eric (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Barange, Manuel (University of Tasmania. Centre for Marine Socioecology) ;
Barrier, Nicolas (University of Montpellier. Institut de Recherche pour le Développement) ;
Bianchi, Daniele (University of California. Department of Atmospheric and Oceanic Sciences) ;
Blanchard, Julia (University of Tasmania. Institute for Marine and Antarctic Studies) ;
Bopp, Laurent (Institut Pierre Simon Laplace des sciences de l'environnement global) ;
Büchner, Matthias (Potsdam Institute for Climate Impact Research) ;
Bulman, Catherine (Commonwealth Scientific and Industrial Research Organization. Marine and Atmospheric Research (Hobart, Austràlia)) ;
Carozza, David A. (McGill University. Department of Earth and Planetary Sciences) ;
Christensen, Villy (University of British Columbia. Institute for the Oceans and Fisheries) ;
Coll, Marta (University of Montpellier. Institut de Recherche pour le Développement) ;
Dunne, Johan (Princeton University. National Oceanic and Atmospheric Administration. Geophysical Fluid Dynamics Laboratory) ;
Fulton, Elizabeth A. (University of Tasmania. Centre for Marine Socioecology) ;
Jennings, Simon (University of East Anglia. School of Environmental Sciences) ;
Jones, Miranda C. (University of British Columbia. Institute for the Oceans and Fisheries) ;
Mackinson, Steve (Sottish Pelagic Fishermen's Association. Heritage House) ;
Maury, Olivier (University of Montpellier. Institut de Recherche pour le Développement) ;
Niiranen, Susa (Stockholm University. RStockholm Resilience Centre) ;
Oliveros-Ramos, Ricardo (Instituto del Mar del Perú) ;
Roy, Tilla (University of Tasmania. Institute for Marine and Antarctic Studies) ;
Fernandes, Jose A. (AZTI Tecnalia. Marine Research Division) ;
Schewe, Jacob (Potsdam Institute for Climate Impact Research) ;
Shin, Yunne-Jai (University of Montpellier. Institut de Recherche pour le Développement) ;
Silva, Tiago A. M. (Centre for Environment, Fisheries and Aquaculture Science. Lowestoft Laboratory) ;
Steenbeek, Jeroen (Ecopath International Initiative) ;
Stock, Charles (Princeton University. Geophysical Fluid Dynamics Laboratory) ;
Verley, Philippe (AMAP Montpellier) ;
Volkholz, Jan (Potsdam Institute for Climate Impact Research) ;
Walker, Nicola (Centre for Environment, Fisheries and Aquaculture Science. Lowestoft Laboratory) ;
Worm, Boris (Dalhousie University. Department of Biology)
While the physical dimensions of climate change are now routinely assessed through multimodel intercomparisons, projected impacts on the global ocean ecosystem generally rely on individual models with a specific set of assumptions. [...]
2019 - 10.1073/pnas.1900194116
Proceedings of the National Academy of Sciences, Vol. 116, issue 26 (June 2019) , p. 12907-12912
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3.
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8 p, 1.4 MB |
Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma
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Trilla-Fuertes, Lucía (Biomedica Molecular Medicine (Madrid)) ;
Ghanem, Ismael (Hospital Universitario La Paz (Madrid)) ;
Maurel, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
G-Pastrián, Laura (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Mendiola, Marta (Centro de Investigación Biomédica en Red de Cáncer) ;
Peña, Cristina (Hospital Universitario La Paz (Madrid)) ;
López-Vacas, Rocío (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Prado-Vázquez, Guillermo (Biomedica Molecular Medicine (Madrid)) ;
López-Camacho, Elena (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Zapater-Moros, Andrea (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Heredia Soto, Victoria (Hospital Universitario La Paz (Madrid)) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ;
García-Alfonso, Pilar (Hospital General Universitario Gregorio Marañón) ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
Conill, Carles (Hospital Clínic i Provincial de Barcelona) ;
García-Carbonero, Rocío (Hospital Universitario 12 de Octubre (Madrid)) ;
Heath, Karen E. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Ramos-Ruiz, Ricardo (Genomics Unit Cantoblanco, Parque Científico de Madrid, C/ Faraday 7, 28049, Madrid, Spain) ;
Llorens, Carlos (Biotechvana SL, Parque Científico de Madrid, C/ Faraday 7, 28049, Madrid, Spain) ;
Campos-Barros, Ángel (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Gámez-Pozo, Angelo (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Feliu, Jaime (Universidad Autónoma de Madrid) ;
Vara, Juan Ángel Fresno (Instituto de Investigación Sanitaria del Hospital Universitario La Paz)
Anal squamous cell carcinoma (ASCC) is a rare neoplasm. Chemoradiotherapy is the standard of care, with no therapeutic advances achieved over the past three decades. Thus, a deeper molecular characterization of this disease is still necessary. [...]
2020 - 10.1016/j.tranon.2020.100778
Translational Oncology, Vol. 13 (may 2020)
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22 p, 2.4 MB |
A protocol for the intercomparison of marine fishery and ecosystem models : fish-MIP v1.0
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Tittensor, Derek P. (United Nations Environment Programme World Conservation Monitoring Centre) ;
Eddy, Tyler D. (Dalhousie University. Department of Biology) ;
Lotze, Heike K.. (Dalhousie University. Department of Biology) ;
Galbraith, Eric (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Cheung, William W. L. (Nippon Foundation-Nereus Program) ;
Barange, Manuel (FAO (Organisme). Departamento de Pesca y Acuicultura) ;
Blanchard, Julia (University of Tasmania. Institute for Marine and Antarctic Studies) ;
Bopp, Laurent (Laboratoire des Sciences du Climat et de l'Environnement) ;
Bryndum-Buchholz, Andrea (Dalhousie University. Department of Biology) ;
Büchner, Matthias (Postdam-Institut für Klimafolgensforschung) ;
Bulman, Catherine (CSIRO Oceans and Atmosphere) ;
Carozza, David A. (McGill University. Department of Earth and Planetary Sciences) ;
Christensen, Villy (University of British Columbia. Institute for the Oceans and Fisheries) ;
Coll, Marta (Institut de Ciències del Mar) ;
Dunne, Johan (United States. National Oceanic and Atmospheric Administration. Geophysical Fluid Dynamics Laboratory) ;
Fernandes, Jose A. (Plymouth Marine Laboratory) ;
Fulton, Elizabeth A. (CSIRO Oceans and Atmosphere) ;
Hobday, Alistair J. (CSIRO Oceans and Atmosphere) ;
Huber, Veronika (Postdam-Institut für Klimafolgensforschung) ;
Jennings, Simon (University of East Anglia. School of Environmental Sciences) ;
Jones, Miranda (Nippon Foundation-Nereus Program) ;
Lehodey, Patrick (Collecte Localisation Satellites) ;
Link, Jason S. (United States. National Oceanic and Atmospheric Administration) ;
Mackinson, Steve (Centre for Environment, Fisheries and Aquaculture Science (Great Britain)) ;
Maury, Olivier (University of Cape Town, Department of Oceanography) ;
Niiranen, Susa (Stockholm University. Stockholm Resilience Centre) ;
Oliveros-Ramos, Ricardo (Instituto del Mar del Perú) ;
Roy, Tilla (Laboratoire des Sciences du Climat et de l'Environnement) ;
Schewe, Jacob (Postdam-Institut für Klimafolgensforschung) ;
Shin, Yunne-Jai (Institut de recherche pour le développement (France)) ;
Silva, Tiago (Centre for Environment, Fisheries and Aquaculture Science (Great Britain)) ;
Stock, Charles (United States. National Oceanic and Atmospheric Administration) ;
Steenbeek, Jeroen (Ecopath International Initiative) ;
Underwood, Philip J. (United Nations Environment Programme World Conservation Monitoring Centre) ;
Volkholz, Jan (Postdam-Institut für Klimafolgensforschung) ;
Watson, James R. (Oregon State University. College of Earth) ;
Walker, Nicola (Centre for Environment, Fisheries and Aquaculture Science (Great Britain)) ;
Universitat Autònoma de Barcelona.
Departament de Matemàtiques
Model intercomparison studies in the climate and Earth sciences communities have been crucial to building credibility and coherence for future projections. They have quantified variability among models, spurred model development, contrasted within-and among-model uncertainty, assessed model fits to historical data, and provided ensemble projections of future change under specified scenarios. [...]
2018 - 10.5194/gmd-11-1421-2018
Geoscientific model development, Vol. 11 (2018) , p. 1421-1442
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5.
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13 p, 1.0 MB |
Adaptive Pathways : Possible Next Steps for Payers in Preparation for Their Potential Implementation
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Vella Bonanno, Patricia (Department of Pharmacoepidemiology, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde) ;
Ermisch, Michael (Pharmaceutical Department, National Association of Statutory Health Insurance Funds) ;
Godman, Brian (Karolinska Institutet (Estocolm, Suècia). Division of Clinical Pharmacology) ;
Martin, Antony P. (Health Economics Centre, University of Liverpool Management School) ;
Van Den Bergh, Jesper (Department of Health) ;
Bezmelnitsyna, Liudmila (National Research Institution for Public Health) ;
Bucsics, Anna (Mechanism of Coordinated Access to Orphan Medicinal Products (MoCA)) ;
Arickx, Francis (Department of Pharmaceutical Policy, National Institute for Health and Disability Insurance) ;
Bybau, Alexander (Zilveren Kruis Achmea) ;
Bochenek, Tomasz (Department of Drug Management, Faculty of Health Sciences, Jagiellonian University Medical College) ;
van de Casteele, Marc (Department of Pharmaceutical Policy, National Institute for Health and Disability Insurance) ;
Diogène Fadini, Eduard (Hospital Universitari Vall d'Hebron) ;
Eriksson, Irene (Karolinska Institutet (Estocolm, Suècia). Department of Medicine Solna) ;
Fürst, Jurij (Medicinal Products Department, Health Insurance Institute of Slovenia) ;
Gad, Mohamed (Global Health and Development Group, Imperial College) ;
Greičiūtė-Kuprijanov, Ieva (Department of Pharmacy, Ministry of Health of the Republic of Lithuania) ;
van der Graaff, Martin (National Health Care Institute (ZIN)) ;
Gulbinovič, Jolanta (State Medicines Control Agency) ;
Jones, Jan (Scottish Medicines Consortium) ;
Joppi, Roberta (Clinical Research and Drug Assessment Unit) ;
Kalaba, Marija (Pediatric Cardiology, Primary Healthcare Centre "Zemun") ;
Laius, Ott (Department of Post-authorisation Safety, State Agency of Medicines) ;
Langner, Irene (Wissenschaftliches Institut der AOK) ;
Mardare, Ileana (Faculty of Medicine, Public Health and Management Department, "Carol Davila" University of Medicine and Pharmacy Bucharest) ;
Markovic-Pekovic, Vanda (Department of Social Pharmacy, Medical Faculty, University of Banja Luka) ;
Magnusson, Einar (Department of Health Services, Ministry of Health) ;
Melien, Oyvind (Norwegian Directorate for Health) ;
Meshkov, Dmitry O. (Department of Health) ;
Petrova, Guenka I. (Department of Social Pharmacy and Pharmacoeconomics, Faculty of Pharmacy, Medical University of Sofia) ;
Selke, Gisbert (Wissenschaftliches Institut der AOK) ;
Sermet, Catherine (Institut de Recherche et Documentation en Economie de la Santé (IRDES)) ;
Simoens, Steven (KU Leuven Department of Pharmaceutical and Pharmacological Sciences) ;
Schuurman, Ad (National Health Care Institute (ZIN)) ;
Ramos, Ricardo (Health Technology Assessment, Pricing and Reimbursement Department, Central Administration of the Health System, National Authority of Medicines and Health Products (I.P., INFARMED)) ;
Rodrigues, Jorge (Health Technology Assessment, Pricing and Reimbursement Department, Central Administration of the Health System, National Authority of Medicines and Health Products (I.P., INFARMED)) ;
Zara, Corinne (Servei Català de la Salut) ;
Zebedin-Brandl, Eva (Main Association of Austrian Social Insurance Institutions. Department of Pharmaceutical Affairs) ;
Haycox, Alan (Health Economics Centre, University of Liverpool Management School) ;
Universitat Autònoma de Barcelona
Medicines receiving a conditional marketing authorization through Medicines Adaptive Pathways to Patients (MAPPs) will be a challenge for payers. The "introduction" of MAPPs is already seen by the European Medicines Agency (EMA) as a fait accompli, with payers not consulted or involved. [...]
2017 - 10.3389/fphar.2017.00497
Frontiers in Pharmacology, Vol. 8 (august 2017)
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