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1.
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22 p, 1.6 MB |
Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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Weber, Minéia (Universitat de Barcelona) ;
Mera, Paula (Instituto de Salud Carlos III) ;
Casas, Josefina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Salvador, Javier (Clínica Universidad de Navarra) ;
Rodríguez, Amaia (Clínica Universidad de Navarra) ;
Alonso, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sebastián, David (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Soler-Vázquez, MCarmen (Universitat de Barcelona) ;
Montironi, Carla (Hospital Clínic i Provincial de Barcelona) ;
Recalde, Sandra (Universitat de Barcelona) ;
Fucho, Raquel (Universitat de Barcelona) ;
Calderon-Dominguez, María (Universitat de Barcelona) ;
Mir, Joan Francesc (Universitat de Barcelona) ;
Bartrons, Ramon (Universitat de Barcelona) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Infantes, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zorzano Olarte, Antonio (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Casals, Nuria (Universitat Internacional de Catalunya) ;
Valentí, Victor (Clínica Universidad de Navarra) ;
Frühbeck, Gema (Clínica Universidad de Navarra) ;
Herrero, Laura (Instituto de Salud Carlos III) ;
Serra, Dolors (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high-fat diet (HFD)-induced obesity and NAFLD in mice by enhancing liver fatty acid oxidation (FAO). [...]
2020 -  10.1096/fj.202000678R
FASEB Journal, Vol. 34 Núm. 9 (january 2020) , p. 11816-11837
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8 p, 641.4 KB |
Safety and efficacy of ribociclib plus letrozole in patients with HR+, HER2- advanced breast cancer : Results from the Spanish sub-population of the phase 3b CompLEEment-1 trial
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Salvador Bofill, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Moreno Anton, Fernando (Hospital Clínico San Carlos (Madrid)) ;
Rodriguez Sanchez, Cesar Augusto (Hospital Universitario de Salamanca-IBSAL) ;
Galve Calvo, Elena (Hospital de Basurto (Bilbao, Biscaia)) ;
Hernando Melia, Cristina (Hospital Clínic Universitari (València)) ;
Ciruelos, Eva (Hospital Universitario 12 de Octubre (Madrid)) ;
Vidal Losada, Maria (Hospital Clínic i Provincial de Barcelona) ;
Jiménez-Rodriguez, Begoña (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
de la Cruz Merino, Luis (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Martínez Jañez, Noelia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villanueva Vazquez, Rafael (Institut Català d'Oncologia) ;
de Toro Salas, Ruben (Hospital Universitario de Jerez (Jerez de la Frontera)) ;
Antón, Antonio (Hospital Universitario Miguel Servet (Saragossa)) ;
Alvarez Lopez, Isabel Manuela (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Gavila Gregori, Joaquin (Fundació Institut Valencià d'Oncologia) ;
Quiroga Garcia, Vanesa (Institut Català d'Oncologia) ;
Vicente Rubio, Elena (Hospital Universitario Insular de Gran Canaria) ;
de la Haba Rodríguez, Juan Rafael (Universidad de Córdoba) ;
Gonzalez-Santiago, Santiago (Hospital Universitario San Pedro de Alcántara) ;
Diaz Fernandez, Nieves (Hospital Universitario San Juan de Alicante) ;
Barnadas i Molins, Agustí (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cantos Sanchez de Ibargüen, Blanca (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Delgado Mingorance, Juan Ignacio (Hospital Universitario Infanta Cristina) ;
Bellet Ezquerra, Meritxell (Vall d'Hebron Institut d'Oncologia) ;
de Casa, Sonia (Novartis Farmacèutica, SA) ;
Gimeno, Asuncion (Novartis Farmacèutica, SA) ;
Martin, Miguel (Hospital General Universitario Gregorio Marañón) ;
Universitat Autònoma de Barcelona
Breast cancer is the most common malignancy and the second leading cause of cancer-related mortality in Spanish women. Ribociclib in combination with endocrine therapy (ET) has shown superiority in prolonging survival in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer (ABC) vs. [...]
2022 - 10.1016/j.breast.2022.09.006
Breast, Vol. 66 (september 2022) , p. 77-84
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3.
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12 p, 1.6 MB |
Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and Stratifying Staphylococcus aureus Infections
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Montagut, Enrique-J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Acosta, Gerardo (Institut de Química Avançada de Catalunya) ;
Albericio, Fernando (University of KwaZulu-Natal) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht, Utrecht University) ;
Salvador, Juan-Pablo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
An immunochemical strategy to detect and quantify AIP-IV, the quorum sensing (QS) signaling molecule produced by Staphylococcus aureus agr type IV, is reported here for the first time. Theoretical calculations and molecular modeling studies have assisted on the design and synthesis of a suitable peptide hapten (AIPIVS), allowing to obtain high avidity and specific antibodies toward this peptide despite its low molecular weight. [...]
2022 - 10.1021/acsinfecdis.1c00670
ACS infectious diseases, Vol. 8 (02 2022) , p. 645-656
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4.
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8 p, 917.4 KB |
Impact of subtrochanteric fractures in the geriatric population : better pre-fracture condition but poorer outcome than pertrochanteric fractures: evidence from the Spanish Hip Fracture Registry
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Aguado, Héctor J. (Universidad de Valladolid) ;
Castillón-Bernal, Pablo (Universitat Autònoma de Barcelona) ;
Ventura-Wichner, Paula S.. (Institut Germans Trias i Pujol) ;
Cervera-Díaz, María C. (Hospital Clínico Universitario de Valladolid) ;
Abarca-Vegas, Javier (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
García-Flórez, Luis (Hospital Clínico Universitario de Valladolid) ;
Salvador-Carreño, Jordi (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
García-Virto, Virginia (Hospital Clínico Universitario de Valladolid) ;
Simón-Pérez, Clarisa (Universidad de Valladolid) ;
Ojeda-Thies, Cristina (Hospital Universitario 12 de Octubre (Madrid)) ;
Sáez-López, Pilar (Head Coordinator of the Spanish National Hip Fracture Registry (Madrid)) ;
González-Montalvo, Juan Ignacio (Universidad Autónoma de Madrid. Departamento de Medicina)
Clinical management in orthogeriatric units and outcome indicators are similar for extracapsular fragility hip fractures, without discriminating between subtrochanteric and pertrochanteric fractures. [...]
2022 - 10.1186/s10195-022-00637-8
Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology, Vol. 23 (march 2022)
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5.
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12 p, 5.1 MB |
A new Early Cretaceous lizard in Myanmar amber with exceptionally preserved integument
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Čerňanský, Andrej (University in Bratislava. Department of Ecology) ;
Stanley, Edward L. (Florida Museum of Natural History. Department of Natural History) ;
Daza, Juan D. (Sam Houston State University. Department of Biological Sciences) ;
Bolet, Arnau (Institut Català de Paleontologia Miquel Crusafont) ;
Salvador Arias, J. (Unidad Ejecutora Lillo (Argentina)) ;
Bauer, Aaron M.. (Villanova University. Department of Biology (USA)) ;
Vidal-García, Marta (University of Calgary. Department of Cell Biology and Anatomy) ;
Bevitt, Joseph J. (Australian Centre for Neutron Scattering) ;
Peretti, Adolf (Peretti Museum Foundation) ;
Aung, Nyi Nyi (Peretti Museum Foundation) ;
Evans, Susan E. (University College London. Department of Cell and Developmental Biology)
We here report on a well-preserved juvenile lizard specimen in Albian amber (ca. 110 mya) from the Hkamti site (Myanmar). This new taxon is represented by an articulated skull and the anterior portion of the trunk, including the pectoral girdle and forelimbs. [...]
2022 - 10.1038/s41598-022-05735-5
Scientific reports, Vol. 12 (January 2022) , art. 1660
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25 p, 6.8 MB |
Unusualmorphology in the mid-Cretaceous lizard Oculudentavis
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Bolet, Arnau (Institut Català de Paleontologia Miquel Crusafont) ;
Stanley, Edward L. (Florida Museum of Natural History. Department of Natural History) ;
Daza, Juan D. (Sam Houston State University. Department of Biological Sciences) ;
Salvador Arias, J. (Unidad Ejecutora Lillo) ;
Čerňanský, Andrej (University in Bratislava. Department of Ecology) ;
Bauer, Aaron M.. (Villanova University. Department of Biology) ;
Bevitt, Joseph J. (Australian Centre for Neutron Scattering) ;
Peretti, Adolf (Peretti Museum Foundation) ;
Evans, Susan E. (University College London. Department of Cell and Developmental Biology)
Oculudentavis khaungraae was described based on a tiny skull trapped in amber. The slender tapering rostrum with retracted narial openings, large eyes, and short vaulted braincase led to its identification as the smallest avian dinosaur on record, comparable to the smallest living hummingbirds. [...]
2021 - 10.1016/j.cub.2021.05.040
Current Biology, Vol. 31 (2021) , 1-12
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94 p, 4.4 MB |
Abordatge posterior de colze sense osteotomia d'olècranon (abordatge de Newcastle) pel tractament de les fractures de l'húmer distal
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Salvador Carreño, Jordi ;
Torrens Cànoves, Carlos, dir.
L'abordatge de Newcastle, eficaç per la implantació d'una artroplàstia, es útil pel tractament de les fractures articulars de l'húmer distal amb reducció oberta i fixació interna (ROFI). L'avantatge de poder abordar un fractura articular d'húmer distal per aquesta via es que permet canviar la indicació d'osteosíntesi a artroplàstia intraoperatòriament ja que l'aparell extensor es conserva (a diferencia de la osteotomia d'olècranon) cosa que dificultaria/impossibilitaria la implantació protèsica.
El abordaje de Newcastle, eficaz para la implantación de una artroplastia, es útil para el tratamiento de las fracturas articulares del húmero distal con reducción abierta y fijación interna (RAFI). [...]
The Newcastle approach, effective for implantation of an arthroplasty, is useful for the treatment of articular fractures of the distal humerus with open reduction and internal fixation (ORIF). The advantage of being able to approach a fracture of the distal humerus by this approach is that it allows changing the indication from osteosynthesis to arthroplasty intraoperatively since the extensor apparatus is preserved (unlike the olecranon osteotomy), something that would make prosthetic implantation difficult or impossible.
2020
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12 p, 822.4 KB |
Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01)
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Lluch, Ana (GEICAM, Spanish Breast Cancer Group, Madrid, Spain) ;
Barrios, Carlos H. (LACOG, Latin American Cooperative Oncology Group, Porto Alegre, Brazil) ;
Torrecillas, Laura (Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (Mèxic). Centro Médico Nacional 20 de Noviembre) ;
Ruiz-Borrego, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bines, Jose (Instituto Nacional de Câncer, Rio de Janeiro, Brazil) ;
Segalla, Jose (Hospital Amaral Carvalho, Sao Paolo, Brazil) ;
Guerrero-Zotano, Ángel L (Fundació Institut Valencià d'Oncologia) ;
García-Sáenz, Jose A. (Hospital Clínico San Carlos (Madrid)) ;
Torres, Roberto (Instituto Nacional del Cáncer, Santiago, Chile) ;
de la Haba Rodríguez, Juan Rafael (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
García-Martínez, Elena (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Gómez, Henry L. (GECOPERU, Peruvian Oncological Clinical Studies Group, Lima, Peru) ;
Llombart, Antonio (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Salvador Bofill, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Baena-Cañada, José M. (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Calvo, L.. (Complejo Hospitalario Universitario de A Coruña) ;
Pérez-Michel, Laura (Hospital de San José, Ciudad Obregón, Sonora, México) ;
Ramos, Manuel (Centro Oncológico de Galicia, A Coruña, Spain) ;
Fernández, Isaura (Complexo Hospitalario Universitario de Vigo) ;
Rodríguez-Lescure, Álvaro (Hospital General Universitario de Elche) ;
Cárdenas, Jesús (Centro Médico Colima, Colima, México) ;
Vinholes, Jeferson (Unidade de Novos Tratamentos CliniOnco, Porto Alegre, Brazil) ;
Martínez de Dueñas, Eduardo (Consorci Hospitalari Provincial de Castelló) ;
Godes, Maria J. (Hospital General Universitario de Valencia) ;
Seguí, Miguel A. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Antón, Antonio (Instituto de Investigación Sanitaria de Aragón) ;
López-Álvarez, Pilar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Moncayo, Jorge (Social S Hospital Teodoro Maldonado Carbo, Guayaquil, Ecuador) ;
Amorim, Gilberto (Oncologistas Associados-Oncologia D'Or, Rio de Janeiro, Brazil) ;
Villar, Esther (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Reyes, Salvador (Hospital Beneficiencia Española, San Luis de Potosí, México) ;
Sampaio, Carlos (Clínica Amo Itaigara, Salvador, Brazil) ;
Cardemil, Bernardita (Hospital Base de Valdivia, Valdivia, Chile) ;
Escudero, Maria J. (GEICAM, Spanish Breast Cancer Group, Madrid, Spain) ;
Bezares, Susana (GEICAM, Spanish Breast Cancer Group, Madrid, Spain) ;
Carrasco, Eva (GEICAM, Spanish Breast Cancer Group, Madrid, Spain) ;
Martín Jiménez, Miguel (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Universitat Autònoma de Barcelona
Operable triple-negative breast cancers (TNBCs) have a higher risk of relapse than non-TNBCs with standard therapy. The GEICAM/2003-11_CIBOMA/2004-01 trial explored extended adjuvant capecitabine after completion of standard chemotherapy in patients with early TNBC. [...]
2019 - 10.1200/JCO.19.00904
Journal of Clinical Oncology, Vol. 38 (december 2019) , p. 203-213
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15 p, 353.7 KB |
The second level of St. Bonaventure's Transcendent Aesthetics : speculating the divine Trinity through the good
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Salvador González, José María (Universidad Complutense de Madrid)
After pointing out that St. Bonaventure of Bagnoregio conceives his Aesthetics as a free way to be able to ascend contemplatively towards God, this article seeks to explain the surprising and ingenious "arguments" (deeply imbued by faith) that this author proposes to base the second level of the "transcendent" stage of his peculiar Aesthetics. [...]
Tras señalar que San Buenaventura de Bagnoregio concibe su estética como un camino expedito para poder ascender contemplativamente hacia Dios, el presente artículo busca explicar los sorprendentes e ingeniosos "argumentos" (profundamente imbuidos por la fe) que dicho autor propone para fundamentar el segundo nivel del estadio "trascendente" de su peculiar Estética. [...]
2020
Mirabilia, Núm. 31 (2020) , p. 741-755
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