Schaffer, A.M. - Search Results - UAB Digital Repository of Documents

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Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition / Winkler, R. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mägdefrau, A.S. (Friedrich Schiller University Jena) ; Piskor, E.M. (Friedrich Schiller University Jena) ; Kleemann, M. (Friedrich Schiller University Jena) ; Beyer, M. (University Medical Center Mainz) ; Linke, K. (Friedrich Schiller University Jena) ; Hansen, L. (Friedrich Schiller University Jena) ; Schaffer, A.M. (Friedrich Schiller University Jena) ; Hoffmann, M.E. (Institute of Molecular Biology) ; Poepsel, S. (University of Cologne) ; Heyd, F. (Freie Universität Berlin) ; Beli, P. (Institute of Molecular Biology) ; Möröy, T. (Institut de Recherches Cliniques de Montréal) ; Mahboobi, S. (University of Regensburg) ; Krämer, O.H. (University Medical Center Mainz) ; Kosan, C. (Friedrich Schiller University Jena) ; Universitat Autònoma de Barcelona
Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting of the transcription factor MYC remains challenging. Here, we show that inhibition of the histone deacetylase 6 (HDAC6) using the HDAC6 inhibitor Marbostat-100 (M-100) reduces oncogenic MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced aggressive B-cell lymphoma. [...]
2022 - DOI (Digital Object Identifier)

10.1038/s41388-022-02450-3
Oncogene, Vol. 41 Núm. 40 (30 2022) , p. 4560-4572

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See also: similar author names
219	Schaffer, A. C.
24	Schaffer, A.C.
2	Schaffer, Arthur A.

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