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9 p, 1.4 MB TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes / McGraw, Kathy L. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Cluzeau, Thomas (Centre Hospitalier Universitaire de Nice (França)) ; Sallman, David A. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Basiorka, Ashley A. (University of South Florida (Estats Units d'Amèrica)) ; Irvine, Brittany A. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Ling, Zhang (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Epling-Burnette, P. K. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Rollison, Dana E. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sokol, Lubomir (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica)) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Maciejewski, Jaroslaw (Taussig Cancer Institute (Cleveland, Estats Units d'Amèrica)) ; List, Alan F. (Moffitt Cancer Center and Research Institute (Florida, Estats Units d'Amèrica))
Abstract:P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. [...]
2015 - 10.18632/oncotarget.5255
Oncotarget, Vol. 6 Núm. 33 (october 2015)  
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