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19 p, 3.0 MB Mutational signatures are markers of drug sensitivity of cancer cells / Levatić, Jurica (Institute for Research in Biomedicine (IRB Barcelona)) ; Salvadores, Marina (Institute for Research in Biomedicine (IRB Barcelona)) ; Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Supek, Fran (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Genomic analyses have revealed mutational footprints associated with DNA maintenance gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. [...]
2022 - 10.1038/s41467-022-30582-3
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2926  
Detailed record - Creative Commons

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