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248 p, 7.7 MB Two-dimensional engineering of molecular nanoparticles for biological applications / Tatkiewicz, Witold Ireneusz ; Veciana i Miró, Jaume, dir. ; Ratera Bastardas, Imma, dir. ; Palet i Ballús, Cristina ; Universitat Autònoma de Barcelona. Departament de Química
El trabajo realizado en esta tesis se ha centrado en dos sistemas de nanopartículas moleculares que tienen un uso potencial en el campo de la nanomedicina: i) vesículas lipídicas - entidades supramoleculares que se proponen como sistemas de liberación de fármacos y ii) cuerpos de inclusión (Inclusion Bodies, IBs) - nanopartículas formadas por agregados proteicos. [...]
This Thesis is focused on two systems of molecular nanoparticles that have a prospective use in nanomedicine. These systems are: (i) lipidic vesicles - supramolecular entities that are already used as drug delivery systems and (ii) Inclusion Bodies (IBs) - proteic nanoaggregates, that are emerging as a new tool in the light of tissue engineering The first part of this work is focused on the comparison of a vesicular system prepared by DELOS - susp, a compressed fluid-based single-step method previously developed in our group, and conventional multi-step processes that are usually employed for vesicle production, like thin film hydratation or sonication followed by extrusion. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2015  
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3 Tatkiewicz, Witold
3 Tatkiewicz, Witold I.
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