UAB Digital Repository of Documents 5 records found  Search took 0.03 seconds. 
1.
25 p, 6.2 MB Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions / Kumbhar, Ramhari (University of Texas at Austin) ; Sanchez, Anthony (University of Texas at Austin) ; Perren, Jullian (University of Texas at Austin) ; Gong, Fade (Baylor College of Medicine) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Medina, Frank (University of Texas at Austin) ; Devanathan, Sravan K. (University of Texas at Austin) ; Xhemalce, Blerta (University of Texas at Austin) ; Matouschek, Andreas (University of Texas at Austin) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buck-Koehntop, Bethany A. (University of Utah) ; Miller, Kyle M. (University of Texas at Austin) ; Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149  
2.
11 p, 1.8 MB The long journey to bring a Myc inhibitor to the clinic / Whitfield, Jonathan R. (Vall d'Hebron Institut d'Oncologia) ; Soucek, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Whitfield and Soucek discuss decades of research and a vast array of strategies that are finally yielding clinical trials for Myc inhibitors in cancer. The oncogene Myc is deregulated in the majority of human tumors and drives numerous hallmarks of cancer. [...]
2021 - 10.1083/jcb.202103090
The journal of cell biology, Vol. 220 (june 2021)  
3.
31 p, 7.6 MB Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking / Casas, Maria (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ; Fadó, Rut (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ; Domínguez, José Luis (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ; Roig, Aina (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ; Kaku, Moena (Ibaraki University College of Agriculture, Japan) ; Chohnan, Shigeru (Ibaraki University College of Agriculture, Japan) ; Solé Piñol, Montserrat (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Dickson, Eamonn James (University of California) ; Casals, Nuria (Universitat Internacional de Catalunya)
GuA1-containing AMPA receptors play a key role in synaptic plasticity and cognition. Casas et al. demonstrate that the sensing of nutrients by CPT1C regulates the phosphatase activity of SAC1, and consequently PI(4)P levels, at the contact sites between the endoplasmic reticulum and the trans-Golgi network to control the trafficking of GluA1 receptors to the cell surface of neurons. [...]
2020 - 10.1083/jcb.201912045
The journal of cell biology, Vol. 219 (september 2020)  
4.
21 p, 7.3 MB Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging / Piñeiro-Hermida, Sergio (Centro Nacional de Investigaciones Oncológicas) ; Autilio, Chiara (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pérez-Gil, Jesús (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Here, we show that physiological aging in mice leads to degenerative and fibrotic-like pathologies in the lung and that telomerase gene therapy prevents the onset of these pathologies. Our findings highlight telomerase activation as a potential therapeutic strategy for lung degenerative pathologies associated with aging. [...]
2020 - 10.1083/jcb.202002120
The journal of cell biology, Vol. 219 (august 2020)  
5.
13 p, 4.1 MB Cytokine secretion requires phosphatidylcholine synthesis / Tian, Yong (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Pate, Caroline (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Garcia Andreolotti, Alberto (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Wang, Limin (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Tuomanen, Elaine (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Boyd, Kelli (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Claro Izaguirre, Enrique (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Jackowski, Suzanne (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica))
Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway. Here, we demonstrate that CCTα-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex. [...]
2008 - 10.1083/jcb.200706152
The Journal of cell biology, Vol. 181, Num. 6 (June 2008) , p. 945-957  

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.