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1.
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18 p, 1.2 MB |
Multicentric investigation on the safety, feasibility and usability of the ABLE lower-limb robotic exoskeleton for individuals with spinal cord injury : a framework towards the standardisation of clinical evaluations
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Wright, Mark Andrew (Institut Germans Trias i Pujol. Institut Guttmann) ;
Herzog, Franziska (Heidelberg University Hospital (Alemanya)) ;
Mas-Vinyals, Anna (ABLE Human Motion S.L.) ;
Carnicero-Carmona, Alfons (ABLE Human Motion S.L.) ;
Lobo-Prat, Joan (ABLE Human Motion S.L.) ;
Hensel, Cornelia (Heidelberg University Hospital (Alemanya)) ;
Franz, Steffen (Heidelberg University Hospital (Alemanya)) ;
Weidner, Norbert (Heidelberg University Hospital (Alemanya)) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann) ;
Rupp, Rüdiger (Heidelberg University Hospital (Alemanya)) ;
Universitat Autònoma de Barcelona
Robotic lower-limb exoskeletons have the potential to provide additional clinical benefits for persons with spinal cord injury (SCI). However, high variability between protocols does not allow the comparison of study results on safety and feasibility between different exoskeletons. [...]
2023 -  10.1186/s12984-023-01165-0
Journal of neuroengineering and rehabilitation, Vol. 20 (april 2023)
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2.
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19 p, 13.0 MB |
Detection of Sleep-Disordered Breathing in Patients with Spinal Cord Injury Using a Smartphone
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Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Ferrer-Lluis, Ignasi (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Jané, Raimon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Patients with spinal cord injury (SCI) have an increased risk of sleep-disordered breathing (SDB), which can lead to serious comorbidities and impact patients' recovery and quality of life. However, sleep tests are rarely performed on SCI patients, given their multiple health needs and the cost and complexity of diagnostic equipment. [...]
2021 - 10.3390/s21217182
Sensors (Basel, Switzerland), Vol. 21 (october 2021)
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3.
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11 p, 1.6 MB |
Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia
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Guardiola-Ripoll, Maria (Centro de Investigación Biomédica en Red de Salud Mental) ;
Sotero-Moreno, Alejandro (FIDMAG Germanes Hospitalàries Research Foundation) ;
Almodóvar-Payá, Carmen (Centro de Investigación Biomédica en Red de Salud Mental) ;
Hostalet, Noemí (FIDMAG Germanes Hospitalàries Research Foundation) ;
Guerrero-Pedraza, Amalia (Benito Menni, Complejo Asistencial en Salud Mental) ;
Ramiro, Núria (Hospital San Rafael (Barcelona, Catalunya)) ;
Ortiz-Gil, Jordi (Hospital General de Granollers. Unitat de Psicologia) ;
Arias, Barbara (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals) ;
Madre Rull, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
Soler-Vidal, Joan (Benito Menni, Complejo Asistencial en Salud Mental) ;
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental) ;
McKenna, Peter J. (Centro de Investigación Biomédica en Red de Salud Mental) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Fatjó-Vilas, Mar (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
The DISC1 gene is one of the most relevant susceptibility genes for psychosis. However, the complex genetic landscape of this locus, which includes protective and risk variants in interaction, may have hindered consistent conclusions on how DISC1 contributes to schizophrenia (SZ) liability. [...]
2022 - 10.1038/s41598-022-10660-8
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 7351
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4.
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17 p, 1.7 MB |
Transcutaneous Cervical Spinal Cord Stimulation Combined with Robotic Exoskeleton Rehabilitation for the Upper Limbs in Subjects with Cervical SCI : Clinical Trial
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García-Alén, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Benito-Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann) ;
Medina-Casanovas, Josep (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury P. (University of Louisville) ;
Edgerton, Victor (Rancho Research Institute) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Restoring arm and hand function is a priority for individuals with cervical spinal cord injury (cSCI) for independence and quality of life. Transcutaneous spinal cord stimulation (tSCS) promotes the upper extremity (UE) motor function when applied at the cervical region. [...]
2023 - 10.3390/biomedicines11020589
Biomedicines, Vol. 11 (february 2023)
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5.
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18 p, 30.1 MB |
Preclinical Development of a Therapy for Chronic Traumatic Spinal Cord Injury in Rats Using Human Wharton's Jelly Mesenchymal Stromal Cells : Proof of Concept and Regulatory Compliance
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Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Puigdomenech-poch, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Romeo-Guitart, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Marmolejo Martínez-Artesero, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cabrera-Pérez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jaramillo, Jessica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kumru, Hatice (Universitat Autònoma de Barcelona. Departament de Medicina) ;
García-lópez, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Samsó, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll-Bonet, Ruth (Banc de Sang i Teixits)
(1) Background: the use of Mesenchymal Stromal Cells (MSC) in emerging therapies for spinal cord injury (SCI) hold the potential to improve functional recovery. However, the development of cell-based medicines is challenging and preclinical studies addressing quality, safety and efficacy must be conducted prior to clinical testing; (2) Methods: herein we present (i) the characterization of the quality attributes of MSC from the Wharton's jelly (WJ) of the umbilical cord, (ii) safety of intrathecal infusion in a 3-month subchronic toxicity assessment study, and (iii) efficacy in a rat SCI model by controlled impaction (100 kdynes) after single (day 7 post-injury) and repeated dose of 1 × 10 MSC,WJ (days 7 and 14 post-injury) with 70-day monitoring by electrophysiological testing, motor function assessment and histology evaluation; (3) Results: no toxicity associated to MSC,WJ infusion was observed. [...]
2022 - 10.3390/cells11142153
Cells, Vol. 11 Núm. 14 (7-2 2022) , p. 2153
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6.
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16 p, 2.2 MB |
Transcutaneous electrical neuromodulation of the cervical spinal cord depends both on the stimulation intensity and the degree of voluntary activity for training. A pilot study
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Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Rodríguez-Cañón, María (Institut Germans Trias i Pujol. Institut Guttmann) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soriano Crespo, Ignasi (Institut Germans Trias i Pujol. Institut Guttmann) ;
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury (University of Louisville) ;
Navarro, X. (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation offers promise in improving hand function. However, it is still unknown which stimulus intensity or which muscle force level could be better for this improvement. [...]
2021 - 10.3390/jcm10153278
Journal of clinical medicine, Vol. 10 Núm. 15 (january 2021) , p. 3278
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7.
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13 p, 4.4 MB |
Assessment of trunk flexion in arm reaching tasks with electromyography and smartphone accelerometry in healthy human subjects
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Castillo-Escario, Yolanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls-Solé, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Alen, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jané Campos, Raimon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Trunk stability is essential to maintain upright posture and support functional movements. In this study, we aimed to characterize the muscle activity and movement patterns of trunk flexion during an arm reaching task in sitting healthy subjects and investigate whether trunk stability is affected by a startling acoustic stimulus (SAS). [...]
2021 - 10.1038/s41598-021-84789-3
Scientific reports, Vol. 11 (march 2021)
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8.
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18 p, 4.3 MB |
Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
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Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann) ;
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodríguez-Cañón, María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Benito-Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann) ;
Navarro, X. (Xavier) (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury (Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA) ;
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. [...]
2021 - 10.3390/jcm10020195
Journal of clinical medicine, Vol. 10 (january 2021)
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9.
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9 p, 853.6 KB |
GH deficiency in patients with spinal cord injury : efficacy/safety of GH replacement, a pilot study
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Cuatrecasas, Guillem (Universitat Oberta de Catalunya) ;
Kumru, Hatice (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Coves, M. Josep (Institut Germans Trias i Pujol. Institut Guttmann) ;
Vidal, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Growth hormone (GH) was shown to stimulate proliferation, migration and survival of neural cells in animal models. GH deficiency (GHD) was reported following traumatic brain lesions; however, there are not available data in spinal cord injury (SCI) patients. [...]
2018 - 10.1530/EC-18-0296
Endocrine Connections, Vol. 7 (august 2018) , p. 1031-1039
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