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14 p, 2.3 MB TALEN mediated gene editing in a mouse model of Fanconi anemia / Pino-Barrio, Maria José (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Giménez, Yari (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Villanueva, Mariela (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Hildenbeutel, Marcus (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Sánchez-Dominguez, Rebeca (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas. Grupo de Citogenética Molecular) ; Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Río, Paula (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Cathomen, Toni (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Mussolino, Claudio (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Bueren, Juan (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Navarro Ordóñez, Susanna (Centro de Investigación Biomédica en Red de Enfermedades Raras)
The promising ability to genetically modify hematopoietic stem and progenitor cells by precise gene editing remains challenging due to their sensitivity to in vitro manipulations and poor efficiencies of homologous recombination. [...]
2020 - 10.1038/s41598-020-63971-z
Scientific reports, Vol. 10 (April 2020) , art. 6997  
Detailed record - Creative Commons

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35 Villanueva, Maria
35 Villanueva, María
1 Villanueva, María José
3 Villanueva, Merce
3 Villanueva, Mercè
2 Villanueva, Miguel
2 Villanueva, Mikel
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