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28 p, 8.7 MB Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin / Garcia-Diaz, Claudia (Samantha Dickson Brain Cancer Unit) ; Pöysti, Anni (Samantha Dickson Brain Cancer Unit) ; Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Clements, Melani P. (Samantha Dickson Brain Cancer Unit) ; Brooks, Lucy J. (Samantha Dickson Brain Cancer Unit. UCL Cancer Institute) ; Galvez-Cancino, Felipe (Cancer Immunology Unit. Research Department of Haematology) ; Castillo, Simon P. (The Institute of Cancer Research) ; Tang, Wenhao T. (Department of Mathematics. Imperial College London) ; Beattie, Gordo (University College London) ; Courtot, Lilas (Samantha Dickson Brain Cancer Unit) ; Ruiz, Sara (Barcelona Institute of Science and Technology (BIST)) ; Roncaroli, Federico (University of Manchester) ; Yuan, Yinyin (The Institute of Cancer Research) ; Marguerat, Samuel (University College London) ; Quezada, Sergio A. (UCL Cancer Institute) ; Heyn, Holger (Universitat Pompeu Fabra) ; Parrinello, Simona (UCL Cancer Institute)
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse models, driven by subtype-associated mutations, to compare matched bulk and margin cells. [...]
2023 - 10.1016/j.celrep.2023.112472
Cell reports, Vol. 42 Núm. 5 (30 2023) , p. 112472  

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