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14 p, 1.3 MB |
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
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Sforzini, Luca (King's College London) ;
Worrell, Courtney (King's College London) ;
Kose, Melisa (King's College London) ;
Anderson, Ian M. (The University of Manchester and Manchester Academic Health Sciences Centre) ;
Aouizerate, Bruno (University of Bordeaux) ;
Arolt, Volker (University of Münster) ;
Bauer, Michael (University Hospital Carl Gustav Carus) ;
Baune, Bernhard T. (The University of Melbourne) ;
Cleare, Anthony J. (National Institute for Health Research Mental Health Biomedical Research Centre) ;
Cowen, Philip J. (University of Oxford) ;
Dinan, Timothy G. (University College Cork) ;
Fagiolini, Andrea (University of Siena) ;
Ferrier, I. Nicol (Newcastle University) ;
Hegerl, Ulrich (Goethe University) ;
Krystal, Andrew D. (Duke University School of Medicine) ;
Leboyer, Marion (Université Paris Est Creteil (UPEC)) ;
McAllister-Williams, R. Hamish (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust) ;
McIntyre, Roger S. (Brain and Cognition Discovery Foundation) ;
Meyer-Lindenberg, Andreas (Heidelberg University) ;
Miller, Andrew H. (Emory University School of Medicine) ;
Nemeroff, Charles B. (University of Texas at Austin) ;
Normann, Claus (Medical Center - University of Freiburg) ;
Nutt, David (Imperial College) ;
Pallanti, Stefano (University of Florence) ;
Pani, Luca (VeraSci) ;
Penninx, Brenda W. J. H. (Vrije Universiteit and GGZinGeest) ;
Schatzberg, Alan F. (Stanford University) ;
Shelton, Richard C. (University of Alabama at Birmingham) ;
Yatham, Lakshmi N. (University of British Columbia) ;
Young, Allan H. (National Institute for Health Research Mental Health Biomedical Research Centre) ;
Zahn, Roland (National Institute for Health Research Mental Health Biomedical Research Centre) ;
Aislaitner, Georgios (Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM)) ;
Butlen-Ducuing, Florence (European Medicines Agency) ;
Fletcher, Christine (Biostatistics, GlaxoSmithKline) ;
Haberkamp, Marion (Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM)) ;
Laughren, Thomas (Laughren Psychopharm Consulting) ;
Mäntylä, Fanni-Laura (GAMIAN-Europe (Global Alliance of Mental Illness Advocacy Networks-Europe)) ;
Schruers, Koen (University of Leuven) ;
Thomson, Andrew (European Medicines Agency) ;
Arteaga-Henríquez, Gara (Hospital Universitari Vall d'Hebron) ;
Benedetti, Francesco (IRCCS Scientific Institute Ospedale San Raffaele) ;
Cash-Gibson, Lucinda (Hospital Universitari Vall d'Hebron) ;
Chae, Woo Ri (Charité - Universitätsmedizin Berlin) ;
De Smedt, Heidi (Janssen Research & Development) ;
Gold, Stefan M. (University Medical Center Hamburg-Eppendorf) ;
Hoogendijk, Witte J. G. (Erasmus University Medical Centre) ;
Mondragón, Valeria Jordán (Medical Director Neuroscience for Region Europe at Novartis Pharma) ;
Maron, Eduard (West Tallinn Central Hospital) ;
Martynowicz, Jadwiga (Janssen Research & Development) ;
Melloni, Elisa (IRCCS Scientific Institute Ospedale San Raffaele) ;
Otte, Christian (Charité - Universitätsmedizin Berlin) ;
Perez-Fuentes, Gabriela (Hospital Universitari Vall d'Hebron) ;
Poletti, Sara (IRCCS Scientific Institute Ospedale San Raffaele) ;
Schmidt, Mark E. (Janssen Pharmaceutica NV) ;
van de Ketterij, Edwin (European Infrastructure for Translational Medicine (EATRIS)) ;
Woo, Katherine (Janssen Research & Development) ;
Flossbach, Yanina (Novartis Pharma AG) ;
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron) ;
Savitz, Adam J. (Department of Neuroscience) ;
Pariante, Carmine M (National Institute for Health Research Mental Health Biomedical Research Centre) ;
Universitat Autònoma de Barcelona
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. [...]
2021 -  10.1038/s41380-021-01381-x
Molecular psychiatry, Vol. 27 (december 2021) , p. 1286-1299
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9 p, 459.1 KB |
Multidecadal ocean variability and NW European ice sheet surges during the last deglaciation
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Knutz, Paul C. (Cardiff University. Department of Earth Sciences) ;
Hall, Ian R. (Cardiff University. Department of Earth Sciences) ;
Zahn, Rainer (Cardiff University. Department of Earth Sciences) ;
Rasmussen, Tine L. (University of Svalbard. Department of Geology) ;
Kuijpers, Antoon (Geological Survey of Denmark and Greenland) ;
Moros, Matthias (Baltic Sea Research Institute (Rostock, Alemanya)) ;
Shackleton, Nick J. (University of Cambridge. Department of Earth Sciences)
A multiproxy paleoceanographic record from the Atlantic margin off the British Isles reveals in unprecedented detail discharges of icebergs and meltwater in response to sea surface temperature increases across the last deglaciation. [...]
2002 - 10.1029/2002GC000351
Geochemistry, geophysics, geosystems, Vol. 3, issue 12 (Dec. 2002) , p. 1-9
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11 p, 815.1 KB |
Progressive reduction in NE Atlantic intermediate water ventilation prior to Heinrich events : response to NW European ice sheet instabilities?
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Peck, V. L. (Cardiff University. School of Earth and Ocean Sciences) ;
Hall, Ian R. (Cardiff University. School of Earth and Ocean Sciences) ;
Zahn, Rainer (Institució Catalana de Recerca i Estudis Avançats) ;
Scourse, J. D. (University of Wales. School of Ocean Sciences)
We present high-resolution benthic δ13C records from intermediate water depth core site MD01-2461 (1153 m water depth), from the Porcupine Seabight, NE Atlantic, spanning 43 to 8 kyr B. P. At an average proxy time step of 160 ± 56 years this core provides information on the linkage between records from the Portuguese Margin and high-latitude North Atlantic basin, allowing additional insights into North Atlantic thermohaline circulation (THC) variability during millennial-scale climatic events of the last glacial. [...]
2007 - 10.1029/2006GC001321
Geochemistry, geophysics, geosystems, Vol. 8, issue 1 (2007)
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18 p, 1.6 MB |
Effects of midlatitude westerlies on the paleoproductivity at the Agulhas Bank slope during the penultimate glacial cycle : evidence from coccolith Sr/Ca ratios
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Mejía, Luz María (Universidad de Oviedo. Departamento de Geología) ;
Ziveri, Patrizia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Cagnetti, Marilisa (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Bolton, Clara (Universidad de Oviedo. Departamento de Geología) ;
Zahn, Rainer (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Marino, Gianluca (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Martínez Méndez, Gema (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Stoll, Heather (Universidad de Oviedo. Departamento de Geología)
Modern primary productivity on the Agulhas Bank, off South Africa, has been proposed to be linked to the midlatitude westerlies. A paleoproductivity record from this area may therefore resolve temporal changes in the westerly dynamics. [...]
2014 - 10.1002/2013PA002589
Paleoceanography, Vol. 29, Issue 7 (July 2014) , p. 697-714
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10 p, 1.6 MB |
Hydrographic changes in the tropical and extratropical Pacific during the last deglaciation
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Rodriguez Sanz, Laura (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Mortyn, P. Graham (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Herguera, Juan Carlos (Centro de Investigación Científica y Educación Superior de Ensenada, Mexico) ;
Zahn, Rainer (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
Fine-scale, paired Mg/Ca-δ18O profiles (Globigerinoides ruber white, sensu lato) from the San Lázaro Basin (SLB) at 25°N in the Northeast Pacific reveal a transition from a predominant presence of tropical/subtropical waters during the last glacial termination (T1) to an increasing influence of fresh and cold California Current waters toward the Holocene. [...]
2013 - 10.1002/palo.20049
Paleoceanography, Vol. 28 No. 3 (September 2013) , p. 529-538
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8 p, 1.6 MB |
Agulhas salt-leakage oscillations during abrupt climate changes of the Late Pleistocene
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Marino, Gianluca (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Zahn, Rainer (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Ziveri, Patrizia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Ziegler, Martin (Cardiff University. School of Earth and Ocean Sciences) ;
Purcell, Conor (Cardiff University. School of Earth and Ocean Sciences) ;
Knorr, Gregor (Cardiff University. School of Earth and Ocean Sciences) ;
Hall, Ian R. (Cardiff University. School of Earth and Ocean Sciences) ;
Elderfield, Henry (University of Cambridge. Department of Earth Sciences)
An ensemble of new, high-resolution records of surface ocean hydrography from the Indian-Atlantic oceanic gateway, south of Africa, demonstrates recurrent and high-amplitude salinity oscillations in the Agulhas Leakage area during the penultimate glacial-interglacial cycle. [...]
2013 - 10.1002/palo.20038
Paleoceanography, Vol. 28 Issue 3 (September 2013) , p. 599-606
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19 p, 1.6 MB |
Deep-dwelling forminifera as thermocline temperature recorders
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Cléroux, Caroline (Laboratoire des Sciences du Climat et de l'Environnement) ;
Cortijo, Elsa (Laboratoire des Sciences du Climat et de l'Environnement) ;
Duplessy, Jean-Claude (Laboratoire des Sciences du Climat et de l'Environnement) ;
Zahn, Rainer (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
We measured the oxygen isotopic composition of the deep-dwelling foraminiferal species G. inflata, G. truncatulinoides dextral and sinistral, and P. obliquiloculata in 29 modern core tops raised from the North Atlantic Ocean. [...]
2007 - 10.1029/2006GC001474
Geochemistry, geophysics, geosystems, Vol. 8, Issue 4 (April 2007)
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