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12 p, 1.8 MB |
The compensatory dynamic of inter-hemispheric interactions in visuospatial attention revealed using rTMS and fMRI
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Plow, Ela B. (Department of Neurology, Beth Israel Deaconess Medical Center, Berenson-Allen Center for Noninvasive Brain Stimulation, Harvard Medical School) ;
Cattaneo, Zaira (C. Mondino National Neurological Institute. Brain Connectivity Center) ;
Carlson, Thomas A. (Harvard University. Department of Psychology) ;
Alvarez, George A. (Harvard University. Department of Psychology) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Battelli, Lorella (Center for Neuroscience and Cognitive Systems@UniTn, Fondazione Istituto Italiano di Tecnologia)
A balance of mutual tonic inhibition between bi-hemispheric posterior parietal cortices is believed to play an important role in bilateral visual attention. However, experimental support for this notion has been mainly drawn from clinical models of unilateral damage. [...]
2014 -  10.3389/fnhum.2014.00226
Frontiers in human neuroscience, Vol. 8 (april 2014)
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13 p, 1.1 MB |
Neonatal handling decreases unconditioned anxiety, conditioned fear, and improves two-way avoidance acquisition : a study with the inbred Roman high (RHA-I)- and low-avoidance (RLA-I) rats of both sexes
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Río-Álamos, Cristóbal (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Blázquez Romero, Glòria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martínez-Membrives, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Institut de Neurociències)
The present study evaluated the long-lasting effects of neonatal handling (NH; administered during the first 21 days of life) on unlearned and learned anxiety-related responses in inbred Roman High- (RHA-I) and Low-avoidance (RLA-I) rats. [...]
2015 - 10.3389/fnbeh.2015.00174
Frontiers in Behavioral Neuroscience, Vol. 9 (july 2015)
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9 p, 894.2 KB |
VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome
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del Hoyo, Laura (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Xicota, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Sola, Susana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Morató, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. [...]
2016 - 10.3389/fnbeh.2016.00193
Frontiers in Behavioral Neuroscience, Vol. 10 (october 2016)
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14 p, 2.1 MB |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity
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Abellaneda-Pérez, Kilian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Vaqué-Alcázar, Lídia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Perellón-Alfonso, Ruben (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona) ;
Kuo, Min-Fang (Leibniz Research Centre for Working Environment and Human Factors) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Nitsche, Michael A. (Department of Neurology, University Medical Hospital Bergmannsheil) ;
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Transcranial direct and alternating current stimulation (tDCS and tACS, respectively) entail capability to modulate human brain dynamics and cognition. However, the comparability of these approaches at the level of large-scale functional networks has not been thoroughly investigated. [...]
2020 - 10.3389/fnins.2019.01440
Frontiers in Neuroscience, Vol. 13 (january 2020)
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12 p, 6.8 MB |
Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats
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Chia, Raymond (St Vincent's Centre for Applied Medical Research) ;
Zhong, Hui (Department of Integrative Biology and Physiology, University of California, Los Angeles) ;
Vissel, Bryce (St Vincent's Centre for Applied Medical Research) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gad, Parag (Department of Neurobiology, University of California, Los Angeles) ;
Universitat Autònoma de Barcelona
A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. Various neuromodulatory techniques including electrical and pharmacological activation of the spinal networks have been successful in restoring locomotor function after SCI. [...]
2020 - 10.3389/fnsys.2019.00082
Frontiers in Systems Neuroscience, Vol. 13 (january 2020)
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16 p, 872.2 KB |
Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration
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Roselló-Busquets, Cristina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
de la Oliva, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez-Mármol, Ramón (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernaiz-Llorens, Marc (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pascual Sánchez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muhaisen, Ashraf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Del Valle, Jaume (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soriano García, Eduardo (Institució Catalana de Recerca i Estudis Avançats)
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. [...]
2019 - 10.3389/fncel.2019.00040
Frontiers in cellular neuroscience, Vol. 13 (February 2019) , art. 40
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19 p, 4.6 MB |
Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling
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Muntsant, Aida (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Shrivastava, Kalpana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Recasens Torné, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Yet, perinatal brain damage has limited therapeutic outcomes. [...]
2019 - 10.3389/fnbeh.2019.00007
Frontiers in Behavioral Neuroscience, Vol. 13 (february 2019)
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11 p, 2.1 MB |
Transcutaneous Electrical Spinal Cord Neuromodulator (TESCoN) Improves Symptoms of Overactive Bladder
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Kreydin, Evgeniy (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Zhong, Hui (Department of Neurobiology, University of California, Los Angeles) ;
Latack, Kyle (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Ye, Shirley (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gad, Parag (The Centre for Neuroscience and Regenerative Medicine, Faculty of Science, University of Technology Sydney)
Non-Surgical modality to reduce incidence of urinary incontinence and improve neurogenic bladder symptom scores (NBSS) in individuals with neurogenic bladder due to spinal cord injury or stroke.
2020 - 10.3389/fnsys.2020.00001
Frontiers in Systems Neuroscience, Vol. 14 (february 2020)
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14 p, 2.2 MB |
Continuous Theta-Burst Stimulation in Children With High-Functioning Autism Spectrum Disorder and Typically Developing Children
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Jannati, Ali (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School) ;
Block, Gabrielle (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School) ;
Ryan, Mary A. (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School) ;
Kaye, Harper L. (Harvard Medical School) ;
Kayarian, Fae B. (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School) ;
Bashir, Shahid (Neuroscience Center, King Fahad Specialist Hospital Dammam) ;
Oberman, Lindsay M. (Neuroplasticity and Autism Spectrum Disorder Program, Department of Psychiatry and Human Behavior, E. P. Bradley Hospital, Warren Alpert Medical School, Brown University) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Rotenberg, Alexander (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School) ;
Universitat Autònoma de Barcelona
Objectives : A neurophysiologic biomarker for autism spectrum disorder (ASD) is highly desirable and can improve diagnosis, monitoring, and assessment of therapeutic response among children with ASD. [...]
2020 - 10.3389/fnint.2020.00013
Frontiers in Integrative Neuroscience, Vol. 14 (march 2020)
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9 p, 1.3 MB |
Interhemispheric and Intrahemispheric Connectivity From the Left Pars Opercularis Within the Language Network Is Modulated by Transcranial Stimulation in Healthy Subjects
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Yoo, Woo-Kyoung (Department of Physical Medicine and Rehabilitation, Hallym University Sacred Heart Hospital) ;
Vernet, Marine (ImpAct Team, Lyon Neuroscience Research Center (CRNL), CNRS UMR5292, INSERM, U1028, University Lyon 1) ;
Hoon Kim, Jeong (Department of Biomedical Engineering, Hanyang University) ;
Brem, Anna-Katharine (Department of Neuropsychology, Memory Clinic Zentralschweiz, Lucerne Psychiatry) ;
Bashir, Shahid (Department of Neurophysiology, Neuroscience Center, King Fahad Specialist Hospital) ;
Ifert-Miller, Fritz (Department of Neurology, Harvard Medical School) ;
Im, Chang-Hwan (Department of Biomedical Engineering, Hanyang University) ;
Eldaief, Mark (Department of Neurology, Harvard Medical School) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Neural activity related to language can be modulated within widespread networks following learning or in response to disruption-including the experimental application of noninvasive brain stimulation. [...]
2020 - 10.3389/fnhum.2020.00063
Frontiers in human neuroscience, Vol. 14 (march 2020)
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14 p, 4.3 MB |
N -Methyl--Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP Mice
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Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Reyes Resina, Irene (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Canela, Enric I. (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Lillo Jové, Jaume (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Tarutani, Airi (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ;
Hasegawa, Masato (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ;
del Ser Badia, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
del Rio, José A. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Kreutz, Michael R. (University Medical Center Hamburg-Eppendorf) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
N -methyl--aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade. Both MAPK- and Ca 2+ -mediated events are important for both neurotransmission and neural cell function and fate. [...]
2018 - 10.3389/fnmol.2018.00273
Frontiers in molecular neuroscience, Vol. 11 (August 2018) , art. 273
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4 p, 398.0 KB |
Novel Non-invasive Strategy for Spinal Neuromodulation to Control Human Locomotion
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Moshonkina, Tatiana (Pavlov Institute of Physiology, Russian Academy of Sciences) ;
Grishin, Alexander (Pavlov Institute of Physiology, Russian Academy of Sciences) ;
Bogacheva, Irina (Pavlov Institute of Physiology, Russian Academy of Sciences) ;
Gorodnichev, Ruslan (Velikie Luki State Academy of Physical Education and Sports) ;
Ovechkin, Alexander (Department of Neurological Surgery, University of Louisville) ;
Siu, Ricardo (Kentucky Spinal Cord Injury Research Center, Frazier Rehab Institute, University of Louisville) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gerasimenko, Yury (Department of Physiology and Biophysics, University of Louisville) ;
Universitat Autònoma de Barcelona
2021 - 10.3389/fnhum.2020.622533
Frontiers in human neuroscience, Vol. 14 (january 2021)
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20 p, 5.4 MB |
Developmental Dynamic Dysphasia : Are Bilateral Brain Abnormalities a Signature of Inefficient Neural Plasticity?
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Berthier, Marcelo L. (Instituto de Investigación Biomédica de Málaga) ;
Dávila, Guadalupe (Universidad de Málaga) ;
Torres-Prioris, María José (Universidad de Málaga) ;
Moreno-Torres, Ignacio (Universidad de Málaga) ;
Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ;
Postigo, María J. (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Fernández, Victoria (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Edelkraut, Lisa (Universidad de Málaga) ;
Moreno-Campos, Lorena (Universidad de Málaga) ;
Molina-Sánchez, Diana (Universidad de Málaga) ;
de Zaldivar, Paloma Solo (Universidad de Málaga) ;
López-Barroso, Diana (Universidad de Málaga) ;
Universitat Autònoma de Barcelona
The acquisition and evolution of speech production, discourse and communication can be negatively impacted by brain malformations. We describe, for the first time, a case of developmental dynamic dysphasia (DDD) in a right-handed adolescent boy (subject D) with cortical malformations involving language-eloquent regions (inferior frontal gyrus) in both the left and the right hemispheres. [...]
2020 - 10.3389/fnhum.2020.00073
Frontiers in human neuroscience, Vol. 14 (march 2020)
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16 p, 2.2 MB |
EEG Biomarkers Related With the Functional State of Stroke Patients
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Sebastián-Romagosa, Marc (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Udina, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ortner, Rupert (g.tec Medical Engineering Spain SL) ;
Dinarès-Ferran, Josep (Universitat de Vic - Universitat Central de Catalunya) ;
Cho, Woosang (g.tec Medical Engineering GmbH) ;
Murovec, Nensi (g.tec Medical Engineering GmbH) ;
Matencio-Peralba, Clara (g.tec Medical Engineering Spain SL) ;
Sieghartsleitner, Sebastian (g.tec Medical Engineering GmbH) ;
Allison, Brendan Z. (University of California at San Diego) ;
Guger, Christoph (g.tec Medical Engineering GmbH)
Recent studies explored promising new quantitative methods to analyze electroencephalography (EEG) signals. This paper analyzes the correlation of two EEG parameters, Brain Symmetry Index (BSI) and Laterality Coefficient (LC), with established functional scales for the stroke assessment. [...]
2020 - 10.3389/fnins.2020.00582
Frontiers in Neuroscience, Vol. 14 (july 2020)
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1 p, 83.1 KB |
Corrigendum : Interhemispheric and Intrahemispheric Connectivity From the Left Pars Opercularis Within the Language Network Is Modulated by Transcranial Stimulation in Healthy Subjects
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Yoo, Woo-Kyoung (Hallym University Sacred Heart Hospital) ;
Vernet, Marine (ImpAct Team, Lyon Neuroscience Research Center (CRNL), CNRS UMR5292, INSERM, U1028, University Lyon 1) ;
Kim, Jung-Hoon (Department of Biomedical Engineering, Hanyang University) ;
Brem, Anna-Katharine (Lucerne Psychiatrye) ;
Bashir, Shahid (King Fahad Specialist Hospital) ;
Ifert-Miller, Fritz (Harvard Medical School) ;
Im, Chang-Hwan (Department of Biomedical Engineering, Hanyang University) ;
Eldaief, Mark (Department of Neurology, Harvard Medical School) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
2020 - 10.3389/fnhum.2020.00249
Frontiers in human neuroscience, Vol. 14 (july 2020)
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25 p, 17.1 MB |
Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models
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Manich, Gemma (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Gómez-López, Ariadna Regina (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Villacampa, Nàdia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Recasens, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Shrivastava, Kalpana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Microglia are the main immune cells of the central nervous system (CNS), and they are devoted to the active surveillance of the CNS during homeostasis and disease. In the last years, the microglial receptor Triggering Receptor Expressed on Myeloid cells-2 (TREM2) has been defined to mediate several microglial functions, including phagocytosis, survival, proliferation, and migration, and to be a key regulator of a new common microglial signature induced under neurodegenerative conditions and aging, also known as disease-associated microglia (DAM). [...]
2020 - 10.3389/fncel.2020.567404
Frontiers in cellular neuroscience, Vol. 14 (november 2020)
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Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease
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Perea, Juan R. (Centro de Biología Molecular Severo Ochoa) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Ávila, Jesús (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Bolós, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. [...]
2018 - 10.3389/fnins.2018.00609
Frontiers in Neuroscience, Vol. 12 (september 2018)
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ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
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Marco-Contelles, José (Laboratori de Química Mèdica, Institut de Química Orgànica General (CSIC), Madrid) ;
Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Esteban, Gerard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ramsay, Rona R. (Biomedical Sciences Research Complex, University of St Andrews) ;
Romero, Alejandro (Universidad Complutense de Madrid) ;
Martínez-Murillo, Ricard (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Carreiras, M. Carmo (University of Lisbon) ;
Ismaili, Lhassane (Université Bourgogne Franche-Comté)
Highlights: The complex nature of Alzheimer's disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. [...]
2016 - 10.3389/fnins.2016.00294
Frontiers in Neuroscience, Vol. 10 (june 2016)
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28 p, 2.4 MB |
Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases
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Di Giovanni, Giuseppe (University of Malta) ;
Svob Strac, Dubravka (Rudjer Boskovic Institute) ;
Sole, Montse (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Unzeta, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tipton, Keith F. (Trinity College Dublin) ;
Mück-Šeler, Dorotea (Rudjer Boskovic Institute Zagreb, Croatia) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Della Corte, Laura (University of Florence) ;
Nikolac Perkovic, Matea (Rudjer Boskovic Institute Zagreb, Croatia) ;
Pivac, Nela (Rudjer Boskovic Institute Zagreb, Croatia) ;
Smolders, Ilse J. (Vrije Universiteit Brussels, Belgium) ;
Stasiak, Anna (Medical University of Lodz, Poland) ;
Fogel, Wieslawa A. (Medical University of Lodz, Poland) ;
De Deurwaerdère, Philippe (Institut of Neurodegenerative Diseases Bordeaux Cedex, France)
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. [...]
2016 - 10.3389/fnins.2016.00541
Frontiers in Neuroscience, Vol. 10 (november 2016)
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Prepulse inhibition predicts spatial working memory performance in the inbred Roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats : relevance for studying pre-attentive and cognitive anomalies in schizophrenia
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Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristóbal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Blázquez Romero, Glòria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martínez-Membrives, Esther (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Giorgi, Osvaldo (University of Cagliari, Italy) ;
Corda, Maria G. (University of Cagliari, Italy) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Institut de Neurociències)
Animal models of schizophrenia-relevant symptoms are increasingly important for progress in our understanding of the neurobiological basis of the disorder and for discovering novel and more specific treatments. [...]
2015 - 10.3389/fnbeh.2015.00213
Frontiers in Behavioral Neuroscience, Vol. 9 (august 2015)
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Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ Concentrations in Down Syndrome Young Adults
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Hoyo Soriano, Laura del (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Xicota, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Sola, Susana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fagundo, Ana B. (Hospital Universitari de Bellvitge) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer's disease (AD), including amyloid deposition by their fifth decade of life. [...]
2015 - 10.3389/fnbeh.2015.00301
Frontiers in Behavioral Neuroscience, Vol. 9 (november 2015)
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37.
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38.
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39.
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9 p, 2.3 MB |
The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome
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Aguilera, Cinthia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Hümmer, Stefan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Masanas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gabau, Elisabeth (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Guitart, Míriam (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Jeyaprakash, A. Arockia (University of Edinburgh) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in KIF1A have been associated with a wide spectrum of neurological disorders. [...]
2021 - 10.3389/fnins.2021.618098
Frontiers in Neuroscience, Vol. 15 (may 2021)
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40.
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9 p, 770.3 KB |
Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease
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Giménez, Sandra (Institut d'Investigació Biomèdica Sant Pau) ;
Farre, Ariadna (Institut d'Investigació Biomèdica Sant Pau) ;
Morente, Fátima (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Toro, Laura (Fundació Catalana Síndrome de Down) ;
Gutiérrez, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Clos, Susana (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Asensio, Amparo (Institut d'Investigació Biomèdica Sant Pau) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Batista, Mar (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Fortuna Gutiérrez, Ana Mª (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
Mayos, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Instituto de Salud Carlos III $a Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) with a high prevalence of obstructive sleep apnea (OSA). These characteristics place the DS population as an optimal model to study the relationship between sleep and AD and to design clinical trials of preventive sleep therapies for AD. [...]
2022 - 10.3389/fnins.2022.838412
Frontiers in Neuroscience, Vol. 16 (march 2022)
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41.
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42.
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21 p, 7.6 MB |
Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment : Comparison between self-administration and experimenter-administration
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Vila-Solés, Laia (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
García-Brito, Soleil (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Aldavert Vera, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Kádár, Elisabet (Universitat de Girona. Departament de Biologia) ;
Huguet, Gemma (Universitat de Girona. Departament de Biologia) ;
Morgado-Bernal, Ignacio (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Segura Torres, Pilar (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. [...]
2022 - 10.3389/fnbeh.2022.1046259
Frontiers in Behavioral Neuroscience, Vol. 16 (december 2022)
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43.
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11 p, 2.4 MB |
The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
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Torres-Simon, Lucia (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Cuesta, Pablo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
del Cerro-Leon, Alberto (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Chino, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Orozco, Lucia H. (Universidad Complutense de Madrid. Centro de Neurociencia Cognitiva y Computacional) ;
Marsh, Elisabeth B. (Department of Neurology, The Johns Hopkins School of Medicine) ;
Gil Gregorio, Pedro (Hospital Universitario Clínico San Carlos (Madrid)) ;
Maestu, Fernando (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer's disease. [...]
2023 - 10.3389/fnhum.2023.1068216
Frontiers in human neuroscience, Vol. 17 (february 2023)
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44.
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12 p, 1.4 MB |
Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment : The NORFACE cohort
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Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-Sánchez, Ainhoa (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Martínez, Joan (Universitat Internacional de Catalunya) ;
Castilla Marti, Miguel (Clínica Oftalmológica Dr. Castilla) ;
Castilla-Martí, Luis (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
Olivé, Clàudia (Universitat Internacional de Catalunya) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitée (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Ricciardi, Mario (Universitat Internacional de Catalunya) ;
Ariton, Diana María (Universitat Internacional de Catalunya) ;
Pytel, Vanesa (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Muñoz, Nathalia (Universitat Internacional de Catalunya) ;
Lleonart, Núria (Universitat Internacional de Catalunya) ;
Aguilera, Núria (Universitat Internacional de Catalunya) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. [...]
2023 - 10.3389/fnins.2023.1076177
Frontiers in Neuroscience, Vol. 17 (february 2023)
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45.
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16 p, 2.2 MB |
Brain system segregation and pain catastrophizing in chronic pain progression
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Delgado-Gallén, Selma (Institut Germans Trias i Pujol. Institut Guttmann) ;
Soler, MD (Institut Germans Trias i Pujol. Institut Guttmann) ;
Cabello-Toscano, María del Rocío (Institut Germans Trias i Pujol. Institut Guttmann) ;
Abellaneda‑Pérez, Kilian (Institut Germans Trias i Pujol. Institut Guttmann) ;
Solana-Sánchez, Javier (Institut Germans Trias i Pujol. Institut Guttmann) ;
España-Irla, Goretti (Institut Germans Trias i Pujol. Institut Guttmann) ;
Roca-Ventura, Alba (Institut Germans Trias i Pujol. Institut Guttmann) ;
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann) ;
Tormos, Josep M. (Institut Germans Trias i Pujol. Institut Guttmann) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Pain processing involves emotional and cognitive factors that can modify pain perception. Increasing evidence suggests that pain catastrophizing (PC) is implicated, through pain-related self-thoughts, in the maladaptive plastic changes related to the maintenance of chronic pain (CP). [...]
2023 - 10.3389/fnins.2023.1148176
Frontiers in Neuroscience, Vol. 17 (march 2023)
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46.
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12 p, 1.6 MB |
Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease : a pilot study
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Cappon, Davide (Harvard Medical School) ;
Fox, Rachel (Deanna and Sidney Wolk Center for Memory Health at Hebrew SeniorLife) ;
den Boer, Tim (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
Yu, Wanting (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
LaGanke, Nicole (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann) ;
Perellón-Alfonso, Ruben (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bartrés-Faz, David (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Manor, Brad (Harvard Medical School) ;
Pascual Leone, Álvaro (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Over 55 million people worldwide are currently diagnosed with Alzheimer's disease (AD) and live with debilitating episodic memory deficits. Current pharmacological treatments have limited efficacy. Recently, transcranial alternating current stimulation (tACS) has shown memory improvement in AD by normalizing high-frequency neuronal activity. [...]
2023 - 10.3389/fnhum.2023.1168673
Frontiers in human neuroscience, Vol. 17 (june 2023)
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47.
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48.
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11 p, 1.5 MB |
Reliability of Upper Limb Pin-Prick Stimulation With Electroencephalography : Evoked Potentials, Spectra and Source Localization
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Triccas, Lisa Tedesco (University of Malta) ;
Camilleri, Kenneth P. (University of Malta) ;
Tracey, Camilleri (University of Malta) ;
Mansoureh, Fahimi Hnazaee (University College London Institute of Neurology) ;
Benjamin, Wittevrongel (KU Leuven) ;
Francesca, Muscat (University of Malta) ;
Boccuni, Leonardo (Institut Germans Trias i Pujol. Institut Guttmann) ;
Dante, Mantini (KU Leuven) ;
Geert, Verheyden (KU Leuven) ;
Universitat Autònoma de Barcelona
In order for electroencephalography (EEG) with sensory stimuli measures to be used in research and neurological clinical practice, demonstration of reliability is needed. However, this is rarely examined. [...]
2022 - 10.3389/fnhum.2022.881291
Frontiers in human neuroscience, Vol. 16 (july 2022)
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49.
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1 p, 64.0 KB |
Corrigendum : EEG biomarkers related with the functional state of stroke patients
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Sebastián-Romagosa, Marc (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ortner, Rupert (g.tec Medical Engineering Spain SL) ;
Dinarès-Ferran, Josep (Universitat de Vic - Universitat Central de Catalunya) ;
Cho, Woosang (g.tec Medical Engineering GmbH) ;
Murovec, Nensi (g.tec Medical Engineering GmbH) ;
Matencio-Peralba, Clara (g.tec Medical Engineering Spain SL) ;
Sieghartsleitner, Sebastian (g.tec Medical Engineering GmbH) ;
Allison, Brendan Z. (University of California at San Diego) ;
Guger, Christoph (g.tec Medical Engineering GmbH)
[This corrects the article DOI: 10. 3389/fnins. 2020. 00582. ].
2022 - 10.3389/fnins.2022.1032959
Frontiers in Neuroscience, Vol. 16 (september 2022)
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50.
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11 p, 897.2 KB |
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin (University of Lille) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Schirmer, Markus D. (Massachusetts General Hospital) ;
Hong, Sungmin (Massachusetts General Hospital) ;
Dalca, Adrian V. (Massachusetts Institute of Technology) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Giese, Anne-Katrin (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Rist, Pamela M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Nardin, Marco (Massachusetts General Hospital) ;
Marinescu, Razvan (Massachusetts Institute of Technology) ;
Wang, Clinton (Massachusetts Institute of Technology) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Leclerc, Xavier (University of Lille) ;
Lopes, Renaud (Institut Pasteur de Lille) ;
Benavente, Oscar R. (Department of Medicine, University of British Columbia) ;
Cole, John W. (Department of Neurology, University of Maryland School of Medicine a) ;
Donatti, Amanda (School of Medical Sciences, University of Campinas (Brasil)) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Department of Neurology, Washington University School of Medicine) ;
Holmegaard, Lukas (Sahlgrenska Academy at University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (Department of Neurology, University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven) ;
Levi, Christopher R. (Department of Neurology, John Hunter Hospital) ;
McArdle, Patrick F. (Department of Medicine, University of Maryland School of Medicine) ;
McDonough, Caitrin W. (Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine) ;
Rolfs, Arndt (Centogene (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Roquer, Jaume (Department of Neurology, University of Miami) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University of Graz) ;
Sharma, Pankaj (St. Peter's Hospitals (Regne Unit)) ;
Slowik, Agnieszka (Department of Neurology, Jagiellonian University Medical College) ;
Sousa, Alessandro (Department of Neurology, University of Maryland School of Medicine) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Department of Neurology, Helsinki University Central Hospital) ;
Tatlisumak, Turgut (Department of Neurology, Sahlgrenska University Hospital) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Department of Neurology Austin Health) ;
Vagal, Achala (Department of Radiology, University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine) ;
Wu, Ona (Massachusetts General Hospital) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
Worrall, Bradford B. (Department of Neurology and Public Health Sciences, University of Virginia) ;
Maguire, Jane M. (University of Technology Sydney) ;
Lindgren, Arne (Department of Clinical Sciences Lund, Lund University) ;
Jern, Christina (Sahlgrenska Academy at University of Gothenburg) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Kuchcinski, Grégory (University of Lille) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. [...]
2021 - 10.3389/fnins.2021.691244
Frontiers in Neuroscience, Vol. 15 (july 2021)
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51.
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12 p, 3.0 MB |
Computational assessment of the impact of Cu(II) and Al(III) on β-amyloid fibrils : Binding sites, structural stability, and possible physiological implications
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Roldán-Martín, Lorena (Universitat Autònoma de Barcelona. Departament de Química) ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química)
One of Alzheimer's disease major hallmarks is the aggregation of β-amyloid peptide, a process in which metal ions play an important role. In the present work, an integrative computational study has been performed to identify the metal-binding regions and determine the conformational impact of Cu(II) and Al(III) ion binding to the β-amyloid (Aβ) fibrillary structure. [...]
2023 - 10.3389/fnins.2023.1110311
Frontiers in Neuroscience, Vol. 17 (February 2023) , art. 1110311
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52.
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16 p, 5.9 MB |
Adult-specific Reelin expression alters striatal neuronal organization : implications for neuropsychiatric disorders
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Pardo, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gregorio, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Montalban, Enrica (Sorbonne University) ;
Pujadas, Lluís (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Elias-Tersa, Alba (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Masachs, Núria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vílchez-Acosta, Alba (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron) ;
Auladell, Carme (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Girault, Jean-Antoine (Sorbonne University) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Nairn, Angus C. (Yale University School of Medicine) ;
Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soriano García, Eduardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. [...]
2023 - 10.3389/fncel.2023.1143319
Frontiers in cellular neuroscience, Vol. 17 (April 2023) , art. 1143319
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53.
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14 p, 2.9 MB |
A mechanistic account of visual discomfort
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Penacchio, Olivier (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació .) ;
Otazu Porter, Xavier (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació) ;
Wilkins, Arnold (University of Essex) ;
Haigh, Sarah M. (University of Nevada)
Much of the neural machinery of the early visual cortex, from the extraction of local orientations to contextual modulations through lateral interactions, is thought to have developed to provide a sparse encoding of contour in natural scenes, allowing the brain to process efficiently most of the visual scenes we are exposed to. [...]
2023 - 10.3389/fnins.2023.1200661
Frontiers in Neuroscience, Vol. 17 (July 2023) , art. 1200661
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54.
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10 p, 1.8 MB |
Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease
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González-Marrero, Ibrahim (Universidad de La Laguna. Departamento de Anatomía Humana) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Johanson, Conrad E. (Alpert Medical School at Brown University. Department of Neurosurgery) ;
Carmona-Calero, Emilia María (Universidad de La Laguna. Departamento de Anatomía Humana) ;
Castañeyra-Ruiz, Leandro (Universidad de La Laguna. Departamento de Anatomía Humana) ;
Brito-Armas, José Miguel (Universidad de La Laguna. Departamento de Psicología) ;
Castañeyra-Perdomo, Agustín (Universidad de La Laguna. Departamento de Anatomía Humana) ;
Castro-Fuentes, Rafael (Universidad de La Laguna. Departamento de Psicología) ;
Universitat Autònoma de Barcelona.
Departament de Psiquiatria i de Medicina Legal
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). [...]
2015 - 10.3389/fncel.2015.00017
Frontiers in cellular neuroscience, Vol. 9 (February 2015) , art. 17
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24 p, 5.9 MB |
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
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Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ;
Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ;
Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ;
Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ;
Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205
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57.
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25 p, 2.6 MB |
Mitochondrial Quality Control in Neurodegenerative Diseases : Focus on Parkinson's Disease and Huntington's Disease
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Franco Iborra, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Perier, Celine (Hospital Universitari Vall d'Hebron. Institut de Recerca)
In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and Huntington's disease (HD). Despite distinct clinical and pathological features, these two neurodegenerative diseases share critical processes, such as the presence of misfolded and/or aggregated proteins, oxidative stress, and mitochondrial anomalies. [...]
2018 - 10.3389/fnins.2018.00342
Frontiers in Neuroscience, Vol. 12 (May 2018) , art. 342
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58.
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18 p, 3.4 MB |
Learning improvement after PI3K activation correlates with de novo formation of functional small spines
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Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ;
Domínguez Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ;
Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ;
Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ;
Sandi, Carmen (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute) ;
Fernández-Ruiz, Antonio (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Martín-Vázquez, Gonzalo (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Herreras, Oscar (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in molecular neuroscience, Vol. 6 (January 2014) , art. 54
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59.
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15 p, 5.1 MB |
Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia
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Hernández Martín, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Redondo-Castro, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López Vales, Rubén (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Research on microglia has established the differentiation between the so-called M1 and M2 phenotypes. However, new frameworks have been proposed attempting to discern between meaningful microglia profiles. [...]
2021 - 10.3389/fnmol.2021.582497
Frontiers in molecular neuroscience, Vol. 14 (May 2021) , art. 582497
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60.
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14 p, 6.5 MB |
Dual role of Lysophosphatidic Acid Receptor 2 (LPA) in amyotrophic lateral sclerosis
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Puigdomenech Poch, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez Muriana, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Andrés-Benito, P (Institut d'Investigació Biomèdica de Bellvitge) ;
Ferrer, Isidro (Institut d'Investigació Biomèdica de Bellvitge) ;
Chun, Jerold (Sanford Burnham Prebys Medical Discovery Institute) ;
López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA). In the central nervous system (CNS), LPA mediates a wide range of effects including neural progenitor cell physiology, neuronal cell death, axonal retraction, and inflammation. [...]
2021 - 10.3389/fncel.2021.600872
Frontiers in cellular neuroscience, Vol. 15 (March 2021) , art. 600872
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61.
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62.
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10 p, 3.4 MB |
Novel graphene electrode for retinal implants : an in vivo biocompatibility study
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Nguyen, Diep (Sorbonne Université. Institut de la Vision) ;
Valet, Manon (Sorbonne Université. Institut de la Vision) ;
Dégardin, Julie (Sorbonne Université. Institut de la Vision) ;
Boucherit, Leyna (Sorbonne Université. Institut de la Vision) ;
Illa, Xavi (Institut de Microelectrònica de Barcelona) ;
De la Cruz, Jose (Institut Català de Nanociència i Nanotecnologia) ;
Del Corro, Elena (Institut Català de Nanociència i Nanotecnologia) ;
Bousquet, Jessica (Institut Català de Nanociència i Nanotecnologia) ;
Garrido, Jose (Institut Català de Nanociència i Nanotecnologia) ;
Hébert, Clément (Institut Català de Nanociència i Nanotecnologia) ;
Picaud, Serge (Sorbonne Université. Institut de la Vision)
Evaluating biocompatibility is a core essential step to introducing a new material as a candidate for brain-machine interfaces. Foreign body reactions often result in glial scars that can impede the performance of the interface. [...]
2021 - 10.3389/fnins.2021.615256
Frontiers in Neuroscience, Vol. 15 (March 2021) , art. 615256
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63.
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10 p, 3.4 MB |
Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy
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Oliván, Sara (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Calvo, Ana Cristina (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ;
Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ;
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Manzano Martínez, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ;
Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón) ;
Tizzano, Eduardo F. (Hospital Universitari Vall d'Hebron) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Osta, Rosario (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in molecular neuroscience, Vol. 9 (August 2016) , art. 76
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