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20 p, 2.8 MB The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways / Gómez-Marín, Elena (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Posavec-Marjanović, Melanija (Institut Germans Trias i Pujol) ; Zarzuela, Laura (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Basurto-Cayuela, Laura (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Guerrero-Martínez, José A. (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Arribas, Gonzalo (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Yerbes, Rosario (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Ceballos-Chávez, María (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Rodríguez-Paredes, Manuel (Johannes Gutenberg University) ; Tomé, Mercedes (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Durán, Raúl V. (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Reyes, José C. (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER))
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements, which we have functionally characterized: i) an amino-terminal, intrinsically disordered domain with transactivation activity; ii) an HMG box with higher binding affinity for double-stranded, four-way-junction DNA than for linear DNA; and iii) a long coiled-coil domain. [...]
2022 - 10.1093/nar/gkac766
Nucleic acids research, Vol. 50 Núm. 17 (january 2022) , p. 9838-9857  
Detailed record - Creative Commons

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