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Articles, 2 records found
Articles 2 records found  
1.
13 p, 7.8 MB V-Myc Immortalizes Human Neural Stem Cells in the Absence of Pluripotency-Associated Traits / Pino-Barrio, María José (Universidad Autónoma de Madrid, Departamento de Biología Molecular) ; García-García, Elisa (Universidad Autónoma de Madrid, Departamento de Biología Molecular) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martínez-Serrano, Alberto (Universidad Autónoma de Madrid, Departamento de Biología Molecular)
A better understanding of the molecular mechanisms governing stem cell self-renewal will foster the use of different types of stem cells in disease modeling and cell therapy strategies. Immortalization, understood as the capacity for indefinite expansion, is needed for the generation of any cell line. [...]
2015 - 10.1371/journal.pone.0118499
PloS one, Vol. 10 (march 2015)  
Detailed record - Creative Commons
2.
14 p, 2.3 MB TALEN mediated gene editing in a mouse model of Fanconi anemia / Pino-Barrio, Maria José (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Giménez, Yari (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Villanueva, Mariela (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Hildenbeutel, Marcus (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Sánchez-Dominguez, Rebeca (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas. Grupo de Citogenética Molecular) ; Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Río, Paula (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Cathomen, Toni (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Mussolino, Claudio (University of Freiburg. Center for Chronic Immunodeficiency - Medical Center) ; Bueren, Juan (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Navarro Ordóñez, Susanna (Centro de Investigación Biomédica en Red de Enfermedades Raras)
The promising ability to genetically modify hematopoietic stem and progenitor cells by precise gene editing remains challenging due to their sensitivity to in vitro manipulations and poor efficiencies of homologous recombination. [...]
2020 - 10.1038/s41598-020-63971-z
Scientific reports, Vol. 10 (April 2020) , art. 6997  
Detailed record - Creative Commons

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