Depósito Digital de Documentos de la UAB Encontrados 14 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.00 segundos. 
1.
19 p, 4.2 MB Spontaneous Cell Detachment and Reattachment in Cancer Cell Lines : An In Vitro Model of Metastasis and Malignancy / Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Herrera-Montávez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Centro de Investigación Biomédica en Red de Cáncer) ; Aasen, Trond (Universitat Autònoma de Barcelona)
There is an unmet need for simplified in vitro models of malignancy and metastasis that facilitate fast, affordable and scalable gene and compound analysis. "Adherent" cancer cell lines frequently release "free-floating" cells into suspension that are viable and can reattach. [...]
2021 - 10.3390/ijms22094929
International journal of molecular sciences, Vol. 22 (may 2021)  
2.
22 p, 4.8 MB Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T : A Rationale for Novel Therapeutic Approaches / Martínez, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Robichaud, Nathaniel (McGill University) ; Sonenberg, Nahum (McGill University) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed the association between eIF4E phosphorylation and cellular resistance to oxidative stress, starvation, and DNA-damaging agents in vitro. [...]
2015 - 10.1371/journal.pone.0123352
PloS one, Vol. 10 (april 2015)  
3.
16 p, 2.1 MB Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis / Varela-Eirín, Marta (Universidade da Coruña) ; Varela-Vázquez, Adrián (Universidade da Coruña) ; Guitián-Caamaño, Amanda ; Paíno, Carlos Luis (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Mato, Virginia (Universidade da Coruña) ; Largo, Raquel (IIS-Fundación Jiménez Díaz UAM) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, Arantxa (Universidad de Salamanca) ; Fonseca, Eduardo (Universidade da Coruña) ; Kandouz, Mustapha (Wayne State University. Department of Pathology, School of Medicine) ; Caeiro Rey, José Ramón (Complejo Hospitalario Universitario de Santiago de Compostela) ; Blanco, Alfonso (University College Dublin C). CellCOM research) ; Mayán, María D. (Universidade da Coruña) ; Universitat Autònoma de Barcelona
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. [...]
2018 - 10.1038/s41419-018-1225-2
Cell death and disease, Vol. 9 (december 2018)  
4.
36 p, 1.9 MB Connexins : Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease / Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Johnstone, Scott (University of Glasgow) ; Vidal-Brime, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lynn, K. Sabrina (Emory University School of Medicine) ; Koval, Michael (Emory University School of Medicine) ; Universitat Autònoma de Barcelona
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. [...]
2018 - 10.3390/ijms19051296
International journal of molecular sciences, Vol. 19 (april 2018)  
5.
5 p, 216.1 KB Connexins, Innexins, and Pannexins : From Biology to Clinical Targets / Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca)
2021 - 10.3390/biom11020155
Biomolecules, Vol. 11 (january 2021)  
6.
25 p, 4.2 MB Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells / Tishchenko, Alexander (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Azorín, Daniel D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vidal-Brime, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; José Muñoz, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jiménez Arenas, Pol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pearce, Christopher (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Girao, Henrique (University of Coimbra. Faculty of Medicine) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms underlying these characteristics are not fully understood. [...]
2020 - 10.3390/cancers12102798
Cancers, Vol. 12 Núm. 10 (2020) , p. 2798  
7.
23 p, 3.8 MB Connexins in cancer : bridging the gap to the clinic / Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Leithe, Edward (Oslo University Hospital. Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital and K.G. Jebsen Colorectal Cancer Research Centre) ; Graham, Sheila V. (University of Glasgow. MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences) ; Kameritsch, Petra (Ludwig-Maximilians-Universität München and Munich University Hospital. Walter Brendel Centre of Experimental Medicine) ; Mayán, María D. (University of A Coruña. CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS)) ; Mesnil, Marc (Université de Poitiers. STIM Laboratory, Faculté des Sciences Fondamentales et Appliquées) ; Pogoda, Kristin (Ludwig-Maximilians-Universität München and Munich University Hospital. Walter Brendel Centre of Experimental Medicine) ; Tabernero, Arantxa (Universidad de Salamanca. Departamento de Bioquímica y Biología Molecular) ; Universitat Autònoma de Barcelona
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and provide for the direct communication between adjacent cells. This type of intercellular communication permits the coordination of cellular activities and plays key roles in the control of cell growth and differentiation and in the maintenance of tissue homoeostasis. [...]
2019 - 10.1038/s41388-019-0741-6
Oncogene, Vol. 38 (february 2019) , p. 4429-4451  
8.
17 p, 1.3 MB Clinical implications of intratumor heterogeneity : challenges and opportunities / Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Capdevila, Claudia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; De Mattos-Arruda, Leticia (Vall d'Hebron Institut d'Oncologia) ; Diaz-Cano, Salvador J. (King's College Hospital NHS Foundation Trust) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. [...]
2020 - 10.1007/s00109-020-01874-2
Journal of Molecular Medicine (Berlin, Germany), Vol. 98 (january 2020) , p. 161-177  
9.
20 p, 5.5 MB Insight into the role and regulation of gap junction genes in lung cancer and identification of nuclear Cx43 as a putative biomarker of poor prognosis / Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sansano, Irene (Hospital Universitari Vall d'Hebron) ; Montero, María Ángeles (Hospital Universitari Vall d'Hebron) ; Romagosa, Cleofé (Hospital Universitari Vall d'Hebron) ; Temprana-Salvador, Jordi (Hospital Universitari Vall d'Hebron) ; Martinez-Marti, Alex (Hospital Universitari Vall d'Hebron) ; Moliné, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández-Losa, J. (Centro de Investigación Biomédica en Red de Cáncer) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. [...]
2019 - 10.3390/cancers11030320
Cancers, Vol. 11 Núm. 3 (march 2019) , p. 320  
10.
21 p, 5.1 MB Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo / Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fuentes Varela, Pedro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteve-Codina, Anna (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Bejar Serrano, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; McGrail, Kimberley (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Thomas, George (Universitat de Barcelona. Departament de Ciències Fisiològiques) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Breast cancer is the most prevalent malignancy in women and there is an urgent need for new therapeutic drugs targeting aggressive and metastatic subtypes, such as hormone-refractory triple-negative breast cancer (TNBC). [...]
2017 - 10.18632/oncotarget.23145
Oncotarget, Vol. 8 (december 2017) , p. 114856-114876  

Depósito Digital de Documentos de la UAB : Encontrados 14 registros   1 - 10siguiente  ir al registro:
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