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13 p, 587.1 KB |
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia : rationale and description
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Brandi, Maria Luisa (FIRMO Foundation (Itàlia)) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Beck-Nielsen, Signe (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Boot, Annemieke (University of Groningen) ;
Briot, Karine (Université de Paris) ;
de Lucas-Collantes, Carmen (Universidad Autónoma de Madrid) ;
Emma, Francesco (Bambino Gesù Children's Hospital IRCCS (Itàlia)) ;
Giannini, Sandro (University of Padua) ;
Haffner, Dieter (Children's Hospital (Alemanya)) ;
Keen, Richard (Royal National Orthopaedic Hospital NHS Trust (Regne Unit)) ;
Levtchenko, Elena (University Hospitals Leuven) ;
Mӓkitie, Outi (Helsinki University Hospital) ;
Nilsson, Ola (Karolinska Institutet and University Hospital) ;
Schnabel, Dirk (Charitè, University Medicine) ;
Tripto-Shkolnik, Liana (Tel-Aviv University) ;
Zillikens, M. Carola (Department of Internal Medicine, Erasmus MC Bone Center - Erasmus University Medical Center, Rotterdam (Holanda)) ;
Liu, Jonathan (Kyowa Kirin International (Regne Unit)) ;
Tudor, Alina (Kyowa Kirin International (Regne Unit)) ;
Mughal, M. Zulf (Royal Manchester Children's Hospital) ;
Universitat Autònoma de Barcelona
X-linked hypophosphataemia (XLH) is a rare, inherited, phosphate-wasting disorder that elevates fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D (1,25(OH)D) synthesis. [...]
2022 -  10.1177/20406223221117471
Therapeutic Advances in Chronic Disease, Vol. 13 (september 2022)
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11 p, 793.9 KB |
The international X-linked hypophosphataemia (XLH) registry (NCT03193476) : rationale for and description of an international, observational study
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Padidela, Raja (University of Manchester) ;
Nilsson, Ola (Örebro University) ;
Makitie, Outi (Helsinki University Hospital (Finlàndia)) ;
Beck-Nielsen, Signe (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Schnabel, Dirk (University Medicine Berlin) ;
Brandi, Maria Luisa (University of Florence) ;
Boot, Annemieke (University of Groningen) ;
Levtchenko, Elena (University Hospitals Leuven (Bèlgica)) ;
Smyth, Michael (Kyowa Kirin International) ;
Jandhyala, Ravi (Medialis Ltd (Regne Unit)) ;
Mughal, Zulf (University of Manchester)
X-linked hypophosphataemia (XLH) is a rare, hereditary, progressive and lifelong phosphate wasting disorder characterised by pathological elevations in fibroblast growth factor (FGF) 23 concentration and activity; XLH has an incidence of approximately 1 in 20-25,000 individuals. [...]
2020 - 10.1186/s13023-020-01434-4
Orphanet Journal of Rare Diseases, Vol. 15 (june 2020)
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16 p, 967.2 KB |
Assessment of Cardiovascular Safety of Anti-Osteoporosis Drugs
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Fuggle, N. R. (University of Southampton) ;
Cooper, Cyrus (University of Oxford) ;
Harvey, N. C. (University of Southampton) ;
Al-Daghri, Nasser (King Saud University) ;
Brandi, Maria Luisa (University Hospital of Florence) ;
Bruyère, Olivier (WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium) ;
Cano Sánchez, Antonio (University of Valencia) ;
Dennison, E. M. (University of Southampton) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kaufman, J.-M. (Universitair Ziekenhuis Gent) ;
Palacios, S. (The Palacios Institute of Women's Health, Madrid) ;
Prieto-Alhambra, D. (University of Oxford) ;
Rozenberg, S. (CHU St Pierre, Bruxelles) ;
Thomas, T. (CHU de Saint-Etienne, France) ;
Tremollieres, F. (Toulouse University Hospital) ;
Rizzoli, R. (Hôpitaux Universitaires Genève) ;
Kanis, John A (Australian Catholic University) ;
Reginster, Jean-Yves (King Saud University) ;
Universitat Autònoma de Barcelona
The incidence of osteoporosis and cardiovascular disease increases with age, and there are potentially shared mechanistic associations between the two conditions. It is therefore highly relevant to understand the cardiovascular implications of osteoporosis medications. [...]
2020 - 10.1007/s40265-020-01364-2
Drugs, Vol. 80 (july 2020) , p. 1537-1552
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15 p, 1.0 MB |
Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength : state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
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Díez Pérez, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brandi, Maria Luisa (University of Florence. Department of Biological, Experimental and Clinical Science) ;
Al-Daghri, Nasser (King Saud University. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science) ;
Branco, Jaime (Universidade Nova de Lisboa. NOVA Medical School) ;
Bruyère, Olivier (Université de Liège) ;
Cavalli, Loredana (University of Florence. Department of Biological, Experimental and Clinical Science) ;
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Cortet, Bernard (University Hospital of Lille (França)) ;
Dawson-Hughes, Bess (Tufts University. Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging) ;
Dimai, Hans Peter (Medical University of Graz. Department of Internal Medicine, Division of Endocrinology and Diabetology) ;
Gonnelli, Stefano (University of Siena. Department of Medicine, Surgery and Neurosciences) ;
Hadji, Peyman (Frankfurter Hormon und Osteoporose Zentrum, Frankfurt, Germany) ;
Halbout, Philippe (International Osteoporosis Foundation, Nyon, Switzerland) ;
Kaufman, Jean-Marc (Universitair Ziekenhuis Gent) ;
Kurth, Andreas (Mayor Teaching Hospital, Charite Medical School) ;
Locquet, Medea (University of Liège. Department of Public Health, Epidemiology and Health Economics) ;
Maggi, Stefania (Institute of Neuroscience. National Research Council, Aging Program) ;
Matijevic, Radmila (Clinical Center of Vojvodina, Clinic for Orthopedic Surgery) ;
Reginster, Jean-Yves (Université de Liège) ;
Rizzoli, René (Geneva University Hospitals (Suïssa)) ;
Thierry, Thomas (University of Lyon. INSERM 1059)
The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. [...]
2019 - 10.1007/s40520-019-01294-4
Aging Clinical and Experimental Research, Vol. 31 (august 2019) , p. 1375-1389
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11 p, 318.1 KB |
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment : results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF)
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Hiligsmann, M. (CAPHRI Care and Public Health Research Institute) ;
Cornelissen, D. (CAPHRI Care and Public Health Research Institute) ;
Vrijens, B. (Université de Liège) ;
Abrahamsen, Bo (University of Southern Denmark) ;
Al-Daghri, Nasser (King Saud University) ;
Biver, E. (Hôpitaux Universitaires de Genève) ;
Brandi, Maria Luisa (Università di Firenze) ;
Bruyère, Olivier (Université de Liège) ;
Burlet, N. (Sanofy Lyon) ;
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Cortet, Bernard (Centre Hospitalier Universitaire de Lille) ;
Dennison, E. M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gasparik, A. (University of Medicine, Pharmacy, Science and Technology of Targu Mures) ;
Grosso, A. (Hôpitaux Universitaires de Genève) ;
Hadji, Peyman (Frankfurt Centre of Bone Health) ;
Halbout, P. (International Osteoporosis Foundation) ;
Kanis, John A (University of Sheffield Medical School) ;
Kaufman, J. M. (Universitair Ziekenhuis Gent) ;
Laslop, A. (Austrian Federal Office for Safety in Health Care) ;
Maggi, Stefania (CNR Aging Branch - Institute of Neuroscience, Padova) ;
Rizzoli, R. (Hôpitaux Universitaires de Genève) ;
Thomas, T. (CHU Saint-Etienne) ;
Tuzun, S. (İstanbul University Cerrahpaşa) ;
Vlaskovska, M. (Medical University Sofia) ;
Reginster, Jean-Yves (King Saud University) ;
Universitat Autònoma de Barcelona
Summary: Many patients at increased risk of fractures do not take their medication appropriately, resulting in a substantial decrease in the benefits of drug therapy. Improving medication adherence is urgently needed but remains laborious, given the numerous and multidimensional reasons for non-adherence, suggesting the need for measurement-guided, multifactorial and individualized solutions. [...]
2019 - 10.1007/s00198-019-05104-5
Osteoporosis International, Vol. 30 Núm. 11 (january 2019) , p. 2155-2165
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14 p, 433.6 KB |
Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis
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Lorentzon, M. (University of Gothenburg) ;
Branco, Jaime (NOVA University of Lisbon) ;
Brandi, Maria Luisa (University of Florence) ;
Bruyère, Olivier (University of Liège) ;
Chapurlat, Roland (Université de Lyon) ;
Cooper, Cyrus (University of Southampton) ;
Cortet, Bernard (CHU Lille) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ferrari, S. (Geneva University Hospitals (Suïssa)) ;
Gasparik, A. (University of Medicine, Pharmacy, Science and Technology of Targu Mures) ;
Herrmann, M. (Medical University of Graz) ;
Jorgensen, N. R. (Copenhagen University Hospital Rigshospitalet) ;
Kanis, J. (Mary MacKillop Institute for Health Research) ;
Kaufman, J. M. (Universitair Ziekenhuis Gent) ;
Laslop, A. (Austrian Agency for Health and Food Safety) ;
Locquet, Medea (University of Liège) ;
Matijevic, Radmila (University of Novi Sad) ;
McCloskey, E. (University of Sheffield) ;
Minisola, S. (Sapienza Università di Roma) ;
Pikner, R. (Klatovska Hospital, Klatovy, Czech Republic) ;
Reginster, Jean-Yves (University of Liège) ;
Rizzoli, R. (Geneva University Hospitals (Suïssa)) ;
Szulc, P. (Université de Lyon) ;
Vlaskovska, M. (Medical University Sofia) ;
Cavalier, Etienne (University of Liège) ;
Universitat Autònoma de Barcelona
Introduction: Increased biochemical bone turnover markers (BTMs) measured in serum are associated with bone loss, increased fracture risk and poor treatment adherence, but their role in clinical practice is presently unclear. [...]
2019 - 10.1007/s12325-019-01063-9
Advances in Therapy, Vol. 36 Núm. 10 (january 2019) , p. 2811-2824
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12 p, 675.8 KB |
Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer : Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG
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Hadji, Peyman (Krankenhaus Nordwest) ;
Aapro, Matti S. (Genolier Cancer Center, Switzerland) ;
Body, Jean-Jacques (CHU Brugmann, Université Libre de Bruxelles, Belgium) ;
Gnant, Michael (Medical University of Vienna, Austria) ;
Brandi, Maria Luisa (University of Florence, Italy) ;
Reginster, Jean-Yves (University of Liège, Belgium) ;
Zillikens, M. Carola (Erasmus MC, Rotterdam, Netherlands) ;
Glüer, Claus-C. (Univeristy of Kiel, Germany) ;
de Villiers, Tobie (University of Stellenbosch, Cape Town, South Africa) ;
Baber, Rod (University of Sydney, Australia) ;
Roodman, G. David (Indiana University School of Medicine, USA) ;
Cooper, Cyrus (University of Southampton, UK) ;
Langdahl, Bente (Aarhus University, Denmark) ;
Palacios, Santiago (Instituto Palacios. Salud y Medicina de la Mujer (Madrid, Espanya)) ;
Kanis, John (Catholic University of Australia, Melbourne, Australia and University of Sheffield, UK) ;
Al-Daghri, Nasser (University of Riyadh, Saudi Arabia) ;
Nogués Solán, Xavier (Universitat Autònoma de Barcelona) ;
Eriksen, Erik Fink (University of Oslo, Norway) ;
Kurth, Andreas (Klinikum Birkenwerder, Germany) ;
Rizzoli, Rene (Geneva University, Switzerland) ;
Coleman, Robert E. (University of Sheffield, UK)
Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently, a number of studies on additional fracture related risk factors, new treatment options as well as real world studies demonstrating a much higher fracture rate than suggested by randomized clinical controlled trials (RCTs). [...]
2017 - 10.1016/j.jbo.2017.03.001
Journal of Bone Oncology, Vol. 7 (June 2017) , p. 1-12
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