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20 p, 932.4 KB

Drug-Drug Interactions with Antiretroviral Drugs in Pregnant Women Living with HIV : Are They Different from Non-Pregnant Individuals? / Bukkems, Vera E. (Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS). Department of Pharmacy) ; Colbers, Angela (Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS). Department of Pharmacy) ; Marzolini, Catia (University of Liverpool. Department of Molecular and Clinical Pharmacology) ; Molto, Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Burger, David M. (Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS). Department of Pharmacy) ; Universitat Autònoma de Barcelona
Although the separate effects of drug-drug interactions and pregnancy on antiretroviral drug pharmacokinetics have been widely studied and described, their combined effect is largely unknown. Physiological changes during pregnancy may change the extent or clinical relevance of a drug-drug interaction in a pregnant woman. [...]
2020 - DOI (Digital Object Identifier)

10.1007/s40262-020-00914-x
Clinical Pharmacokinetics, Vol. 59 (july 2020) , p. 1217-1236

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10 p, 1.6 MB

Etravirine pharmacokinetics in HIV-infected pregnant women / Mulligan, Nikki (University of California (Estats Units d'Amèrica)) ; Schalkwijk, Stein (Radboud University Nijmegen Medical Centre (Nijmegen, Països Baixos)) ; Best, Brookie M. (University of California (Estats Units d'Amèrica)) ; Colbers, Angela (Radboud University Nijmegen Medical Centre (Nijmegen, Països Baixos)) ; Wang, Jiajia (Harvard School of Public Health (Boston, Estats Units d'Amèrica)) ; Capparelli, Edmund V. (University of California (Estats Units d'Amèrica)) ; Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Stek, Alice M. (University of Southern California. School of Medicina (Estats Units d'Amèrica)) ; Taylor, Graham (Imperial College Healthcare National Health Service Trust (Londres, Regne Unit)) ; Smith, Elizabeth (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Hidalgo Tenorio, Carmen (Hospital Universitario Virgen de las Nieves (Granada)) ; Chakhtoura, Nahida (Eunice Kennedy Shriver National Institute of Child Health and Human Development (Bethesda, Estats Units d'Amèrica)) ; Van Kasteren, Marjo (Saint Elisabeth Hospital (Tilburg, Països Baixos)) ; Fletcher, Courtney V. (University of Nebraska Medical Center (Omaha, Estats Units d'Amèrica)) ; Mirochnick, Mark (Boston University School of Medicine (Estats Units d'Amèrica)) ; Burger, David M. (Radboud University Nijmegen Medical Centre (Nijmegen, Països Baixos)) ; PANNA Network ; IMPAACT Network
BACKGROUND: The study goal was to describe etravirine pharmacokinetics during pregnancy and postpartum in HIV-infected women. METHODS: IMPAACT P1026s and PANNA are on-going, non-randomized, open-label, parallel-group, multi-center phase-IV prospective studies in HIV-infected pregnant women. [...]
2016 - DOI (Digital Object Identifier)

10.3389/fphar.2016.00239
Frontiers in Pharmacology, Vol. 7 Núm. 239 (August 2016)

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