Depósito Digital de Documentos de la UAB Encontrados 19 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.00 segundos. 
1.
8 p, 667.2 KB Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia / Philtjens, Stéphanie (University of Antwerp) ; Van Mossevelde, Sara (Antwerp University Hospital (UZA)) ; Van der Zee, Julie (University of Antwerp) ; Wauters, Eline (University of Antwerp) ; Dillen, Lubina (University of Antwerp) ; Vandenbulcke, Mathieu (University Hospitals Leuven (Bèlgica)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Ivanoiu, Adrian (Université Catholique de Louvain) ; Sieben, Anne (Universitair Ziekenhuis Gent) ; Willems, Christiana (Jessa Hospital) ; Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Borroni, Barbara (University of Brescia) ; Padovani, Alessandro (University of Brescia) ; Pastor, Pau (Instituto de Salud Carlos III) ; Diez-Fairen, Monica (Instituto de Salud Carlos III) ; Aguilar, Miquel (Instituto de Salud Carlos III) ; de Mendonça, Alexandre (University of Lisbon) ; Miltenberger-Miltényi, Gabriel (University of Lisbon) ; Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Boada, M. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Ruiz, A. (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Nacmias, B. (University of Florence) ; Sorbi, S. (IRCCS Don Gnocchi) ; Almeida, M.Rosario (University of Coimbra) ; Santana, Isabel (University of Coimbra) ; Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Frisoni, Giovanni B. (IRCCS Fatebenefratelli) ; Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Llado Plarrumani, Albert (Hospital Clínic i Provincial de Barcelona) ; Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ; Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Van den Broeck, Marleen (University of Antwerp) ; Peeters, Karin (University of Antwerp) ; Cras, Patrick (Antwerp University Hospital (UZA)) ; De Deyn, Peter P. (Middelheim and Hoge Beuken) ; Engelborghs, Sebastiaan (Middelheim and Hoge Beuken) ; Cruts, Marc (University of Antwerp) ; Van Broeckhoven, Christine (University of Antwerp) ; Universitat Autònoma de Barcelona
We investigated the genetic role of sortilin (SORT1) in frontotemporal dementia (FTD). SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited FTD. [...]
2018 - 10.1016/j.neurobiolaging.2018.02.011
Neurobiology of Aging, Vol. 66 (june 2018) , p. 181.e3-181.e10  
2.
6 p, 731.5 KB A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort / Stamate, Daniel (University of London) ; Kim, Min (Steno Diabetes Center Copenhagen) ; Proitsi, Petroula (King's College London) ; Westwood, Sarah (University of Oxford) ; Baird, Alison (University of Oxford) ; Nevado-Holgado, Alejo (University of Oxford) ; Hye, Abdul (King's College London) ; Bos, Isabelle (Amsterdam UMC) ; Vos, Stephanie J.B. (Maastricht University) ; Vandenberghe, Rik (Amsterdam UMC) ; Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ; Kate, Mara Ten (Amsterdam UMC. University Medical Center) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Gabel, Silvy (Laboratory for Cognitive Neurology) ; Meersmans, Karen (Laboratory for Cognitive Neurology) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill (GlaxoSmithKline R&D) ; De Roeck, Ellen (University of Antwerp) ; Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ; Sleegers, Kristel (Center for Molecular Neurology. VIB) ; Bordet, Régis (University of Lille) ; Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ; Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, Frans (Maastricht University) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ; Johannsen, Peter (Copenhagen University Hospital) ; Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ; Frölich, Lutz (University of Heidelberg) ; Dobricic, Valerija (University of Lübeck) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Molinuevo, José L. (Universitat Pompeu Fabra) ; Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ; Popp, Julius (Geneva University Hospitals) ; Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ; Bertram, Lars (University of Oslo) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Streffer, Johannes (University of Antwerp) ; Visser, Pieter J. (Amsterdam UMC) ; Lovestone, Simon (Janssen-Cilag UK Ltd) ; Legido-Quigley, Cristina (King's College London) ; Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 - 10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938  
3.
11 p, 783.1 KB Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay / Shi, Liu (University of Oxford) ; Westwood, Sarah (University of Oxford) ; Baird, Alison L. (University of Oxford) ; Winchester, Laura (University of Oxford) ; Dobricic, Valerija (University of Lübeck) ; Kilpert, Fabian (University of Lübeck) ; Hong, Shengjun (University of Lübeck) ; Franke, Andre (Christian-Albrechts-University of Kiel) ; Hye, Abdul (King's College London) ; Ashton, Nicholas J. (South London and Maudsley NHS Foundation) ; Morgan, Angharad R. (Cardiff University) ; Bos, Isabelle (Maastricht University) ; Vos, Stephanie J.B. (Amsterdam UMC. University Medical Center) ; Buckley, Noel J (University of Oxford) ; Kate, Mara ten (Amsterdam UMC. University Medical Center) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (Laboratory for Cognitive Neurology) ; Meersmans, Karen (Laboratory for Cognitive Neurology) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels (UZ Brussel)) ; De Roeck, Ellen E. (Institute Born-Bunge. University of Antwerp) ; Sleegers, Kristel (Center for Molecular Neurology. VIB) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill C. (GlaxoSmithKline R&D) ; Bordet, Régis (University of Lille) ; Molinuevo, José L. (Hospital Clínic i Provincial de Barcelona) ; Rami, Lorena (Universitat Pompeu Fabra) ; Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ; Kettunen, Petronella (University of Oxford) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, Frans (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Geneva University Hospitals) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ; Tainta, Mikel (CITA-Alzheimer Foundation) ; Johannsen, Peter Copenhagen University Hospital ; Teunissen, Charlotte E. (Vrije Universiteit) ; Freund-Levi, Yvonne (King's College London) ; Frölich, Lutz (University of Heidelberg) ; Legido-Quigley, Cristina (Steno Diabetes Center) ; Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Baker, Susan (Janssen R&D) ; Morgan, B.Paul (Cardiff University) ; Streffer, Johannes (Janssen R&D. LLC) ; Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ; Bertram, Lars (University of Oslo) ; Lovestone, Simon (University of Oxford) ; Nevado-Holgado, Alejo (University of Oxford) ; Universitat Autònoma de Barcelona
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. [...]
2019 - 10.1016/j.jalz.2019.06.4951
Alzheimer's & Dementia, Vol. 15 Núm. 11 (november 2019) , p. 1478-1488  
4.
9 p, 1012.4 KB Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity : A cross-sectional analysis from the AB255 Study / Pérez-Grijalba, Virginia (Araclon Biotech S.L.) ; Arbizu, Javier (Clínica Universidad de Navarra) ; Romero, Judith (Araclon Biotech S.L.) ; Prieto, Elena (Clínica Universidad de Navarra) ; Pesini, Pedro (Araclon Biotech S.L.) ; Sarasa, Leticia (Araclon Biotech S.L.) ; Guillen, Fernando (Clínica Universidad de Navarra) ; Monleón, Inmaculada (Araclon Biotech S.L.) ; San-José, Itziar (Araclon Biotech S.L.) ; Martínez-Lage, Pablo (Fundación CITA-Alzheimer) ; Munuera, Josep (Institut de Recerca Sant Joan de Déu) ; Hernández, Isabel (Instituto de Salud Carlos III) ; Buendía, Mar (Universitat Internacional de Catalunya) ; Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ; Alegret, Montserrat (Instituto de Salud Carlos III) ; Ruiz, Agustín (Instituto de Salud Carlos III) ; Tárraga, Lluís (Instituto de Salud Carlos III) ; Boada, Mercè (Instituto de Salud Carlos III) ; Sarasa, Manuel (Araclon Biotech S.L.) ; Goñi Imízcoz, Miguel (Hospital Divino Vallés (Burgos)) ; Pujadas, Francesc ; Villarejo, Alberto ; Frank, Ana ; Peña-Casanova, Jordi ; Fernández, Manuel ; Piñol, Gerard ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Gil, Pedro ; Pascual, Luis F. ; Aguilar Barberà, Miquel ; Frisoni, Giovanni B. ; Matias-Guiu, Jorge ; Andreasen, Niels ; Antúnez, Carmen ; Universitat Autònoma de Barcelona
To facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer's disease, supportive biomarker information is necessary. This study was aimed to investigate the association of plasma amyloid-beta (Aβ) levels with the presence of pathological accumulation of Aβ in the brain measured by amyloid-PET. [...]
2019 - 10.1186/s13195-019-0549-1
Alzheimer's research & therapy, Vol. 11 Núm. 1 (january 2019) , p. 96  
5.
22 p, 986.7 KB Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort / Kim, M. (Steno Diabetes Center Copenhagen) ; Snowden, S. (University of Cambridge) ; Suvitaival, T. (Steno Diabetes Center Copenhagen) ; Ali, A. (Steno Diabetes Center Copenhagen) ; Merkler, D.J. (University of South Florida) ; Ahmad, T. (King's College London) ; Westwood, S. (University of Oxford) ; Baird, A. (University of Oxford) ; Proitsi, P. (King's College London) ; Nevado-Holgado, Alejo (University of Oxford) ; Hye, A. (Steno Diabetes Center Copenhagen) ; Bos, I. (Maastricht University) ; Vos, S. (Maastricht University) ; Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ; Teunissen, C. (Amsterdam Neuroscience) ; ten Kate, M. (Amsterdam Neuroscience) ; Scheltens, P. (Amsterdam UMC. University Medical Center) ; Gabel, Silvy (KU Leuven) ; Meersmans, K. (KU Leuven) ; Blin, Olivier ; Richardson, J. (GlaxoSmithKline R&D) ; De Roeck, E. (University of Antwerp) ; Sleegers, Kristel (VIB) ; Bordet, Régis (University of Lille) ; Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ; Kettunen, P. (John Radcliffe Hospital (Oxford, Regne Unit)) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, F. (Maastricht University) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Peyratout, G. (Lausanne University Hospital) ; Tainta, M. (CITA-Alzheimer Foundation) ; Johannsen, P. (Copenhagen University Hospital) ; Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Frölich, L. (University of Heidelberg) ; Dobricic, V. (University of Lübeck) ; Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ; Frisoni, Giovanni B. (University of Geneva) ; Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ; Wallin, Anders (University of Gothenburg) ; Popp, J. (Geneva University Hospitals) ; Martinez-Lage, P. (CITA-Alzheimer Foundation) ; Bertram, Lars (University of Lübeck) ; Barkhof, Frederik (Amsterdam Neuroscience) ; Ashton, Nicholas J (University of Gothenburg) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, H. (UK Dementia Research Institute) ; Streffer, J. (Janssen Pharmaceutical Companies) ; Visser, P.J. (Amsterdam Neuroscience) ; Lovestone, S. (University of Oxford) ; Legido-Quigley, C. (Steno Diabetes Center Copenhagen) ; Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827  
6.
12 p, 1.1 MB Inflammatory biomarkers in Alzheimer's disease plasma / Morgan, Angharad R. (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, Cardiff University (Regne Unit)) ; Touchard, Samuel (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University (Regne Unit)) ; Leckey, Claire A. (Cardiff University (Regne Unit)) ; O'Hagan, Caroline (Cardiff University (Regne Unit)) ; Nevado-Holgado, Alejo (University of Oxford (Regne Unit)) ; Barkhof, Frederik (University College London) ; Bertram, Lars (Max Planck Institute for Molecular Genetics (Alemanya)) ; Blin, Olivier (Aix-Marseille University (França)) ; Bos, Isabelle (Maastricht University (Països Baixos)) ; Dobricic, Valerija (University of Lübeck (Alemanya)) ; Engelborghs, Sebastiaan (Institute Born-Bunge (Bèlgica)) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia)) ; Froelich, Lutz (University of Heidelberg (Alemanya)) ; Gabel, Silvy (Laboratory for Cognitive Neurology (Leuven, Bèlgica)) ; Johannsen, Peter (Karolinska Institutet (Stockholm, Sweden)) ; Kettunen, Petronella (University of Gothenburg (Gothenburg, Suècia)) ; Kłoszewska, Iwona (Medical University of Lodz (Lodz, Poland)) ; Legido-Quigley, Cristina (Imperial College London) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Martinez-Lage, Pablo (Fundación CITA-Alzheimer Fundazioa (San Sebastian, Spain)) ; Mecocci, Patrizia (University of Perugia (Itàlia)) ; Meersmans, Karen (Laboratory for Cognitive Neurology (Bèlgica)) ; Molinuevo, José Luis (Universitat Pompeu Fabra) ; Peyratout, Gwendoline (Lausanne University Hospital (Suïssa)) ; Popp, Julius (Hopitaux Universitaires Geneve and Universite de Geneve (Suïssa)) ; Richardson, Jill (GlaxoSmithKline R&D (Regne Unit)) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Scheltens, Philip (Vrije Universiteit (Països Baixos)) ; Streffer, Johannes (University of Antwerp) ; Soininen, Hikka (University of Eastern Finland) ; Tainta, Mikel (Fundación CITA Alzheimer (Sant Sebastià, País Basc)) ; Teunissen, Charlotte E (University Hospitals Leuven (Bèlgica)) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Vandenberghe, Rik (Amsterdam University Medical Centers (Països Baixos)) ; Visser, Pieter Jelle (Maastricht University (Països Baixos)) ; Vos, Stephanie (Maastricht University (Països Baixos)) ; Wahlund, Lars Olof (Karolinska Institutet (Estocolm, Suècia)) ; Wallin, Anders (University of Gothenburg Sahlgrenska Academy) ; Westwood, Sarah (University of Oxford (Regne Unit)) ; Zetterberg, Henrik (UK Dementia Research Institute (Londres, Regne Unit)) ; Lovestone, Simon (University of Oxford (Regne Unit)) ; Morgan, B. Paul (Cardiff University (Regne Unit)) ; Bullmore, Edward (University of Cambridge (Regne Unit)) ; Bhatti, Junaid (University of Cambridge (Regne Unit)) ; Chamberlain, Samuel J. (University of Cambridge (Regne Unit)) ; Correia, Marta Morgado (University of Cambridge (Regne Unit)) ; Crofts, Anna L. (Université de Sherbrooke (Canadà)) ; Dickinson, Amber (Addenbroke's Hospital (Cambridge, Regne Unit)) ; Foster, Andy C. (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ; Kitzbichler, Manfred G. (University of Cambridge (Regne Unit)) ; Knight, Clare (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ; Lynall, Mary-Ellen (University of Cambridge (Regne Unit)) ; Maurice, Christina (University of Cambridge (Regne Unit)) ; O'Donnell, Ciara M. (University College London (Regne Unit)) ; Pointon, Linda J. (University of Cambridge (Regne Unit)) ; St George Hyslop, Peter (University of Cambridge (Regne Unit)) ; Turner, Lorinda (University of Cambridge (Regne Unit)) ; Vertes, Petra E. (University of Cambridge (Regne Unit)) ; Widmer, Barry (University of Cambridge (Regne Unit)) ; Williams, Guy (University of Cambridge (Regne Unit)) ; Cavanagh, Jonathan T. O. (Karolinska Institutet (Suècia)) ; Deith, Catherine (Southern General Hospital Glasgow (Escòcia)) ; Farmer, Scott (Bio Med Sciences Inc.(Galveston, Estats Units)) ; McClean, John (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ; McColl, Alison (College of Medical, Veterinary & Life Sciences (Glasgow, Escòcia)) ; McPherson, Andrew (Addenbrooke's Hospital (Cambridge, Regne Unit)) ; Scouller, Paul (Addenbrooke's Hospital (Cambridge, Regne Unit)) ; Sutherland, Murray (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ; Boddeke, Erik W.G.M. (Københavns UniversitetThe institution (Copenhaguen, Dinamarca)) ; Khan, Shahid (GlaxoSmithKline plc. (Regne Unit)) ; Murphy, Philip Stephen (GlaxoSmithKline plc. (Regne Unit)) ; Parker, Christine A. (Wellcome Trust (Londres, Regne Unit)) ; Patel, Jai (GlaxoSmithKline plc. (Regne Unit)) ; Jones, Declan (Janssen Pharmaceuticals (Titusville, Estats Units)) ; de Boer, Peter (Janssen Research & Development (Beerse, Bèlgica)) ; Kemp, John A. (KU Leuven- University Hospital Leuven (Bèlgica)) ; Drevets, Wayne Curtis (Janssen Research & Development (Beerse, Bèlgica)) ; Nye, Jeffrey S. (Janssen Research & Development (Beerse, Bèlgica)) ; Wittenberg, Gayle M. (Janssen Research & Development (Beerse, Bèlgica)) ; Isaac, John T.R. (Johnson & Johnson (Estats Units)) ; Bhattacharya, Anindya (Janssen Research & Development (Beerse, Bèlgica)) ; Carruthers, Niicholas L. (Janssen Research & Development (Beerse, Bèlgica)) ; Kolb, Hartmuth Christian (Janssen Research & Development (Beerse, Bèlgica)) ; Pariante, Carmine M. (King's College London (Regne Unit)) ; Turkheimer, Federico (King's College London (Regne Unit)) ; Barker, Gareth John (King's College London (Regne Unit)) ; Byrom, Heidi (King's College London (Regne Unit)) ; Cash, Diana (King's College London (Regne Unit)) ; Cattaneo, Annamaria (King's College London (Regne Unit)) ; Gee, Anthony (King's College London (Regne Unit)) ; Hastings, Caitlín N.M. (King's College London (Regne Unit)) ; Mariani, Nicole (King's College London (Regne Unit)) ; McLaughlin, Anna Patricia (King's College London (Regne Unit)) ; Mondelli, Valeria (King's College London (Regne Unit)) ; Nettis, Maria Antonietta (King's College London (Regne Unit)) ; Nikkheslat, Naghmeh (King's College London (Regne Unit)) ; Randall, Karen (King's College London (Regne Unit)) ; Sheridan, Hannah C. (King's College London (Regne Unit)) ; Simmons, Camilla (King's College London (Regne Unit)) ; Singh, Nisha (King's College London (Regne Unit)) ; Van Loo, Victoria (King's College London (Regne Unit)) ; Vicente-Rodríguez, Marta (King's College London (Regne Unit)) ; Wood, Tobias (King's College London (Regne Unit)) ; Worrell, Courtney (King's College London (Regne Unit)) ; Zajkowska, Zuzanna (King's College London (Regne Unit)) ; Plath, Niels (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Egebjerg, Jan (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Eriksson, Hans (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Gastambide, Francois (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Adams, Karen Husted (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Jeggo, Ross D. (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Thomsen, Christian (Aalborg Universitetshospital (Aalborg, Dinamarca)) ; Pederson, Jan Torleif (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Campbell, Brian M. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ; Möller, Thomas (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ; Nelson, Bob (H. Lundbeck A/S (Copenhagen, Dinamarca)) ; Zorn, Stevin H. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ; O'Connor, Jason (University of Texas Hlth Sci Ctr San Antonio(Estats Units)) ; Attenburrow, Mary Jane (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ; Baird, Alison (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ; Benjamin, Jithen (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ; Clare, Stuart (John Radcliffe Hosp, Oxford Ctr Funct MRI Brain (Oxford, Anglaterra)) ; Cowen, Philip (University of Oxford (Anglaterra)) ; Huang, I-Shuo Wade (Kennedy Inst Rheumatol (Oxford, Anglaterra)) ; Hurley, Samuel A. (University of Wisconsin-Madison (Madison, Estats Units)) ; Jones, Helen (Warneford Hosp, NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ; Mada, Francisca (Neurosciences & Neurology) ; Nevado-Holgado, Alejo (University of Oxford (Anglaterra)) ; Oladejo, Akitayo (Metropolitan Hospital Center (New York, Estats Units)) ; Ribe, Elena (King's College London (Londres, Anglaterra)) ; Smith, Katy (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ; Vyas, Anviti (University of Oxford (Oxford, Anglaterra)) ; Hughes, Zoe (Praxis Precision Medicines (Cambridge, Regne Unit)) ; Balice-Gordon, Rita (Sanofi S.A. (Gentilly, França)) ; Duerr, James M. (Pfizer Inc.(New York, Estats Units)) ; Piro, Justin R. (Pfizer Inc.(New York, Estats Units)) ; Sporn, Jonathan (Gilgamesh Pharmaceut (New York, Estats Units)) ; Perry, V. Hugh (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ; Cleal, Madeleine (University of Portsmouth (Anglaterra)) ; Fryatt, Gemma (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ; Gomez-Nicola, Diego (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ; Mancuso, Renzo (University of Southampton (Anglaterra)) ; Reynolds, Richard (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ; Harrison, Neil (University fo Sussex (Brighton, Anglaterra)) ; Cercignani, Mara (University fo Sussex (Brighton, Anglaterra)) ; Clarke, Charlotte L. (University of Sussex (Brighton, Regne Unit)) ; Hoskins, Elizabeth (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ; Kohn, Charmaine (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ; Murray, Rosemary (Addenbrooke's Hospital (Cambridge, Regne Unit)) ; Wilcock, Lauren (Sussex Partnership NHS Fdn Trust (Hove, Anglaterra)) ; Wlazly, Dominika (Brighton and Sussex University Hospitals NHS Trust (Sussex, Anglaterra)) ; Mount, Howard T.J. (University of Toronto (Toronto, Canadà)) ; Universitat Autònoma de Barcelona
Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. [...]
2019 - 10.1016/j.jalz.2019.03.007
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 776-787  
7.
13 p, 162.5 KB Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort / Westwood, S. (University of Oxford) ; Baird, Alison L (University of Oxford) ; Anand, S.N. (University of Oxford) ; Nevado-Holgado, Alejo (University of Oxford) ; Kormilitzin, A. (University of Oxford) ; Shi, L. (University of Oxford) ; Hye, A. (King's College London) ; Ashton, Nicholas J (University of Gothenburg) ; Morgan, A.R. (Cardiff University) ; Bos, I. (Maastricht University) ; Vos, S.J.B. (Maastricht University) ; Baker, S. (Janssen R and D) ; Buckley, Noel J (University of Oxford) ; Ten Kate, M. (Vu University Medical Center) ; Scheltens, P. (Vu University Medical Center) ; Teunissen, C.E. (Vu University Medical Center) ; Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (Ku Leuven) ; Meersmans, K. (Ku Leuven) ; Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ; De Roeck, E.E. (Vrije Universiteit Brussel (VUB)) ; Sleegers, Kristel (Center for Molecular Neurology) ; Frisoni, Giovanni B. (Irccs Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, J.C. (GlaxoSmithKline R and D) ; Bordet, Régis (University of Lille) ; Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ; Rami, L. (Universitat Pompeu Fabra) ; Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ; Kettunen, P. (Sahlgrenska Academy at University of Gothenburg) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, F. (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, J. (Geneva University Hospitals) ; Peyratout, G. (Lausanne University Hospital) ; Martinez-Lage, P. (Geneva University Hospitals) ; Tainta, M. (CITA-Alzheimer Foundation) ; Johannsen, P. (Copenhagen University Hospital) ; Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ; Frölich, L. (University of Heidelberg) ; Dobricic, V. (University of Lübeck) ; Legido-Quigley, C. (Steno Diabetes Center) ; Bertram, Lars (University of Oslo) ; Barkhof, Frederik (Ucl Institutes of Neurology and Healthcare Engineering) ; Zetterberg, H. (Ucl Institute of Neurology) ; Morgan, B.P. (Cardiff University) ; Streffer, J. (Janssen R and D. Llc) ; Visser, P.J. (Vu University Medical Center) ; Lovestone, S. (Janssen R and D) ; Universitat Autònoma de Barcelona
We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. [...]
2020 - 10.3233/JAD-190434
Journal of Alzheimer's disease, Vol. 74 Núm. 1 (2020) , p. 213-225  
8.
11 p, 2.6 MB Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies / Huber, M. (LMU Munich) ; Beyer, L. (LMU Munich) ; Prix, C. (LMU Munich) ; Schönecker, S. (LMU Munich) ; Palleis, C. (LMU Munich) ; Rauchmann, B.S. (LMU Munich) ; Morbelli, S. (University of Genoa) ; Chincarini, A. (Genoa section) ; Bruffaerts, R. (University Hospitals Leuven (Bèlgica)) ; Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ; Van Laere, K. (University Hospitals Leuven (Bèlgica)) ; Kramberger, M.G. (University Medical Centre) ; Trost, M. (University Medical Centre) ; Grmek, M. (University Medical Centre) ; Garibotto, V. (Geneva University) ; Nicastro, N. (University of Cambridge) ; Frisoni, Giovanni B. (Geneva University Hospitals) ; Lemstra, A.W. (VU Medical Center Alzheimer Center) ; van der Zande, J. (VU Medical Center Alzheimer Center) ; Pilotto, A. (Isidoro Hospital) ; Padovani, A. (University of Brescia) ; Garcia-Ptacek, S. (Internal Medicine) ; Savitcheva, I. (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Ochoa-Figueroa, M.A. (Linköping University) ; Davidsson, A. (Linköping University Hospital) ; Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ; Peira, E. (University of Genoa) ; Arnaldi, D. (University of Genoa) ; Bauckneht, M. (University of Genoa) ; Pardini, M. (Clinical Neurology. Department of Neuroscience (DINOGMI). University of Genoa) ; Sambuceti, G. (University of Genoa) ; Vöglein, J. (DZNE-German Center for Neurodegenerative Diseases) ; Schnabel, J. (LMU Munich) ; Unterrainer, M. (LMU Munich) ; Perneczky, R. (University of Munich) ; Pogarell, O. (LMU Munich) ; Buerger, K. (University of Munich) ; Catak, C. (University of Munich) ; Bartenstein, P. (Munich Cluster for Systems Neurology (SyNergy)) ; Cumming, P. (Queensland University of Technology) ; Ewers, Michael (DZNE-German Center for Neurodegenerative Diseases) ; Danek, Adrian (Ludwig-Maximilians-Universität) ; Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ; Aarsland, Dag (King's College London) ; Nobili, F. (University of Genoa) ; Rominger, A. (University of Bern) ; Brendel, M. (Munich Cluster for Systems Neurology (SyNergy)) ; Universitat Autònoma de Barcelona
Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and F-fluorodesoxyglucose PET. [...]
2020 - 10.1002/mds.27945
Movement Disorders, Vol. 35 Núm. 4 (january 2020) , p. 595-605  
9.
12 p, 1.3 MB Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset / Hong, S. (University of Lübeck) ; Prokopenko, D. (Massachusetts General Hospital) ; Dobricic, V. (University of Lübeck) ; Kilpert, F. (University of Lübeck) ; Bos, I. (Vrije Universiteit Amsterdam) ; Vos, S.J.B. (Maastricht University) ; Tijms, Betty M (Vrije Universiteit Amsterdam) ; Andreasson, Ulf (Sahlgrenska University Hospital (Suècia)) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ; Cleynen, I. (KU Leuven) ; Gabel, Silvy (KU Leuven) ; Schaeverbeke, J. (KU Leuven) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Teunissen, C.E. (Vrije Universiteit) ; Niemantsverdriet, E. (University of Antwerp) ; Engelborghs, Sebastiaan (UZ Brussel and Vrije Universiteit Brussel (VUB)) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, J.C. (GlaxoSmithKline R&D) ; Bordet, Régis (University of Lille) ; Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ; Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ; Kettunen, P. (University of Oxford) ; Wallin, Anders (University of Gothenburg) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, J. (Lausanne University Hospital) ; Peyratout, G. (Lausanne University Hospital) ; Martinez-Lage, P. (CITA-Alzheimer Foundation) ; Tainta, M. (CITA-Alzheimer Foundation) ; Dobson, R.J.B. (University College London) ; Legido-Quigley, Cristina (King's College London) ; Sleegers, K. (University of Antwerp) ; Van Broeckhoven, C. (University of Antwerp) ; ten Kate, M. (Amsterdam Neuroscience) ; Barkhof, Frederik (University College London) ; Zetterberg, H. (UK Dementia Research Institute) ; Lovestone, S. (University of Oxford) ; Streffer, J. (UCB Biopharma SPRL) ; Wittig, M. (Christian-Albrechts-University of Kiel) ; Franke, Andre (Christian-Albrechts-University of Kiel) ; Tanzi, R.E. (Massachusetts General Hospital) ; Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ; Bertram, Lars (University of Oslo) ; Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. Susceptibility to AD is considerably determined by genetic factors which hitherto were primarily identified using case-control designs. [...]
2020 - 10.1038/s41398-020-01074-z
Translational psychiatry, Vol. 10 Núm. 1 (december 2020) , p. 403  
10.
14 p, 3.0 MB Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset / Homann, Jan (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Osburg, Tim (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Deecke, Laura (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Bos, Isabelle (Vrije Universiteit Amsterdam) ; Vandenberghe, Rik (Neurology Service. University Hospital Leuven) ; Gabel, Silvy (Laboratory for Cognitive Neurology. Department of Neurosciences. KU Leuven) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ; Engelborghs, Sebastiaan (Vrije Universiteit Amsterdam) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Institut Neurosciences Timone. AIX Marseille University) ; Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline RD) ; Bordet, Régis (Lille Neuroscience and Cognition. University of Lille. Inserm. CHU Lille) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ; Clark, Christopher (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zurich) ; Peyratout, Gwendoline (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ; Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Dobson, Richard J.B. (NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust) ; Legido-Quigley, Cristina (King's College London. Institute of Pharmaceutical Sciences) ; Sleegers, Kristel (Center for Molecular Neurology) ; Van Broeckhoven, Christine (University of Antwerp) ; Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College London) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (University College London. UK Dementia Research Institute) ; Lovestone, Simon (University of Oxford. Department of Psychiatry) ; Streffer, Johannes ; ten Kate, Mara (Amsterdam UMC. University Medical Center) ; Vos, Stephanie J.B. (Maastricht University) ; Barkhof, Frederik (University College London) ; Visser, Pieter Jeller (Karolinska Institutet. Department of Neurobiology) ; Bertram, Lars (University of Oslo)
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. [...]
2022 - 10.3389/fnagi.2022.840651
Frontiers in aging neuroscience, Vol. 14 (March 2022) , p. 840651  

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