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14 p, 2.3 MB |
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology
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Simats Oriol, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giralt, Dolors (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gill, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The limited accessibility to the brain has turned the cerebrospinal fluid (CSF) into a valuable source that may contribute to the complete understanding of the stroke pathophysiology. Here we have described the CSF proteome in the hyper-acute phase of cerebral ischemia by performing an aptamer-based proteomic assay (SOMAscan) in CSF samples collected before and 30 min after male Wistar rats had undergone a 90 min Middle Cerebral Artery Occlusion (MCAO) or sham-surgery. [...]
2018 -  10.1038/s41598-018-26237-3
Scientific reports, Vol. 8 (may 2018)
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8 p, 476.6 KB |
Blood Biomarker Panels for the Early Prediction of Stroke-Associated Complications
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Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bustamante, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reverté, Silvia (Hospital de Tortosa Verge de la Cinta) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castellanos, María del Mar (Instituto de Investigación Biomédica de A Coruña) ;
Lara-Rodríguez, Blanca (Hospital Universitari de Bellvitge) ;
Zaragoza, Josep (Hospital de Tortosa Verge de la Cinta) ;
Ventura, Oriol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
van Eendenburg, Cecile (Hospital Universitari de Girona Doctor Josep Trueta) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
López-Cancio, Elena (Hospital Universitario Central de Asturias) ;
Cánovas, David (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Rubiera Del Fueyo, Marta A (Hospital Universitari Vall d'Hebron) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life-threatening complications in patients experiencing stroke during hospitalization. We aimed to test whether blood biomarker panels might predict these complications early after admission. [...]
2021 - 10.1161/JAHA.120.018946
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 10 (february 2021)
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13 p, 1.2 MB |
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
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Loppi, Sanna (University of Arizona) ;
Korhonen, Paula (University of Eastern Finland) ;
Bouvy-Liivrand, Maria (University of Eastern Finland) ;
Caligola, Simone (University of Verona) ;
Turunen, Tiia A. (University of Eastern Finland) ;
Turunen, Mikko P. (University of Eastern Finland) ;
Hernandez de Sande, Ana (University of Eastern Finland) ;
Kołosowska, Natalia (University of Eastern Finland) ;
Scoyni, Flavia (University of Eastern Finland) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lemarchant, Sighild (University of Eastern Finland) ;
Dhungana, Hiramani (University of Helsinki) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Koistinaho, Jari (University of Helsinki) ;
Kanninen, Katja M. (University of Eastern Finland) ;
Kaikkonen, Minna U. (University of Eastern Finland) ;
Giugno, Rosalba (University of Verona) ;
Heinäniemi, Merja (University of Eastern Finland) ;
Malm, Tarja (University of Eastern Finland) ;
Universitat Autònoma de Barcelona
Ischemic stroke, the third leading cause of death in the Western world, affects mainly the elderly and is strongly associated with comorbid conditions such as atherosclerosis or diabetes, which are pathologically characterized by increased inflammation and are known to influence the outcome of stroke. [...]
2020 - 10.1111/acel.13287
Aging Cell, Vol. 20 (december 2020)
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258 p, 8.7 MB |
Potencial terapèutic de nous biomarcadors d'isquèmia cerebral
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Simats Oriol, Alba ;
Montaner, Joan, dir. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa, dir. ;
Vila Bover, Miquel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
L'ictus isquèmic és una de les principals causes de mort i discapacitat arreu. Actualment, l'únic tractament efectiu és la teràpia de reperfusió, ja sigui a través del tractament intravenós amb l'activador tissular del plasminogen (rt-PA) o la retirada del clot mitjançant trombectomia mecànica intra-arterial. [...]
Ischemic stroke is one of the leading causes of death and disability worldwide. Currently, the only effective treatments are reperfusion therapies, via the intravenous administration of recombinant tissue plasminogen activator (rt-PA) or the mechanical removal of the thrombus with stent-retriever or aspiration devices. [...]
[Bellaterra] : Universitat Autònoma de Barcelona, 2018.
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6 p, 210.4 KB |
Circulating cell-free DNA is a predictor of short-term neurological outcome in stroke patients treated with intravenous thrombolysis
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Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mancha, Fernando (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Macher, Hada C. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giralt, Dolors (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribo, Marc (Hospital Universitari Vall d'Hebron) ;
Guerrero, Juan M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Circulating cell-free DNA (cfDNA) has been described as a prognostic marker for several diseases. Its prognostic value for short-term outcome in stroke patients treated with intravenous thrombolysis remains unexplored. [...]
2016 - 10.1177/1849454416668791
Journal of Circulating Biomarkers, Vol. 5 (september 2016)
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11 p, 870.1 KB |
Brain Perihematoma Genomic Profile Following Spontaneous Human Intracerebral Hemorrhage
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Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilalta, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Domingues-Montanari, Sophie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuadrado Godia, Eloy (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribo, Marc (Hospital Universitari Vall d'Hebron) ;
Martinez-Saez, Elena (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Ortega-Aznar, Arantxa (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron)
Spontaneous intracerebral hemorrhage (ICH) represents about 15% of all strokes and is associated with high mortality rates. Our aim was to identify the gene expression changes and biological pathways altered in the brain following ICH. [...]
2011 - 10.1371/journal.pone.0016750
PloS one, Vol. 6 (february 2011)
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207 p, 5.4 MB |
Identificación y uso de biomarcadores pronósticos en el ictus isquémico
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García-Berrocoso, Teresa ;
Montaner, Joan, dir. ;
Fernandez-Cadenas, Israel, dir. ;
Delgado Martínez, María Pilar, dir. ;
García-Dorado, David, tut. ;
Universitat Autònoma de Barcelona.
Departament d'Antropologia Social i Cultural
El ictus es una enfermedad con una elevada morbimortalidad, suponiendo la segunda causa de muerte a nivel mundial y una de las principales causas de discapacidad en el adulto. Aun así, la heterogeneidad entre los pacientes con ictus dificulta anticipar el pronóstico de la enfermedad. [...]
Stroke is a severe disease, being the second cause of death worldwide and one of the main causes of disability. Heterogeneity among stroke patients makes difficult to anticipate the prognosis of the disease. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014
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