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6 p, 1.6 MB |
HomolWat : a web server tool to incorporate 'homologous' water molecules into GPCR structures
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Mayol, Eduardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
García Recio, Ädrian (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Tiemann, Johanna K. S. (Medical University Leipzig. Institute of Medical Physics and Biophysics) ;
Hildebrand, Peter W. (Medical University Leipzig. Institute of Medical Physics and Biophysics) ;
Guixà González, Ramon (Paul Scherrer Institute. Laboratory of Biomolecular Research) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya. Departament de Biociències) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Internal water molecules play an essential role in the structure and function of membrane proteins including G protein-coupled receptors (GPCRs). However, technical limitations severely influence the number and certainty of observed water molecules in 3D structures. [...]
2020 - 10.1093/nar/gkaa440
Nucleic acids research, Vol. 48 (june 2020) , p. W54-W59
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21 p, 4.1 MB |
Control of glutamate release by complexes of adenosine and cannabinoid receptors
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Köfalvi, Attila (University of Coimbra. CNC-Center for Neuroscience and Cell Biology) ;
Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Cai, Ning-Sheng (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica)) ;
Fernández-Dueñas, Víctor (Universitat de Barcelona. Institut de Neurociències) ;
Ferreira, Samira G. (University of Coimbra. CNC-Center for Neuroscience and Cell Biology) ;
Guixà González, Ramon (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Sánchez Soto, Marta (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica)) ;
Yano, Hideaki (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica)) ;
Casadó-Anguera, Verònica (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Cunha, Rodrigo A. (University of Coimbra. Faculty of Medicine) ;
Sebastião, Ana Maria (Universidade de Lisboa. Instituto de Medicina Molecular, Faculdade de Medicina) ;
Ciruela, Francisco (Universitat de Barcelona. Institut de Neurociències) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Casadó, Vicent (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ferré, Sergi (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica))
It has been hypothesized that heteromers of adenosine A receptors (A2AR) and cannabinoid CB receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. [...]
2020 - 10.1186/s12915-020-0739-0
BMC biology, Vol. 18 (january 2020)
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20 p, 4.2 MB |
Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
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Ghosh, Eshan (Indian Institute of Technology, Kanpur) ;
Dwivedi, Hemlata (Indian Institute of Technology, Kanpur) ;
Baidya, Mithu (Indian Institute of Technology, Kanpur) ;
Srivastava, Ashish (Indian Institute of Technology, Kanpur) ;
Kumari, Punita (Indian Institute of Technology, Kanpur) ;
Stepniewski, Tomek (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Kim, Hee Ryung (Sungkyunkwan University, South Korea) ;
Lee, Mi-Hye (Medical University of South Carolina) ;
van Gastel, Jana (University of Antwerp) ;
Chaturvedi, Madhu (Indian Institute of Technology, Kanpur) ;
Roy, Debarati (Indian Institute of Technology, Kanpur) ;
Pandey, Shubhi (Indian Institute of Technology, Kanpur) ;
Maharana, Jagannath (Indian Institute of Technology, Kanpur) ;
Guixà González, Ramon (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Luttrell, Louis M. (Medical University of South Carolina) ;
Chung, Ka Young (Sungkyunkwan University, South Korea) ;
Dutta, Somnath (Indian Institute of Sciences, Bangalore) ;
Selent, Jana (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Shukla, Arun K. (Indian Institute of Technology, Kanpur)
Ghosh et al. discover structural differences between β-arrestin isoforms (β-arrestin 1 and 2), which are universal regulators of signaling and trafficking of G-protein-coupled receptors (GPCRs). These findings have direct implications for understanding the regulatory and signaling paradigms of GPCRs and designing novel therapeutics targeting this important class of receptors.
2019 - 10.1016/j.celrep.2019.08.053
Cell reports, Vol. 28 Núm. 13 (24 2019) , p. 3287-3299.e6
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16 p, 2.6 MB |
Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions
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Javanainen, Matti (Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry) ;
Enkavi, Giray (Department of Physics. University of Helsinki) ;
Guixà González, Ramon (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Kulig, Waldemar (Department of Physics. University of Helsinki) ;
Martinez-Seara, Hector (Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry) ;
Levental, Ilya (Department of Integrated Biology and Pharmacology. McGovern Medical School. University of Texas Health Science Center at Houston) ;
Vattulainen, Ilpo (MEMPHYS - Center for Biomembrane Physics)
G protein-coupled receptors (GPCRs) control cellular signaling and responses. Many of these GPCRs are modulated by cholesterol and polyunsaturated fatty acids (PUFAs) which have been shown to co-exist with saturated lipids in ordered membrane domains. [...]
2019 - 10.1371/journal.pcbi.1007033
PLoS computational biology, Vol. 15 Núm. 5 (may 2019) , p. e1007033
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6 p, 93.8 KB |
Bioestadística i anàlisi de dades [101917]
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Campillo Grau, María Mercedes ;
Pardo Carrasco, Leonardo ;
Guixà González, Ramon ;
Cordomí Montoya, Arnau ;
Universitat Autònoma de Barcelona.
Facultat de Biociències
L'assignatura de Bioestadística i Anàlisi de dades té com objectiu fonamental el introduir l'estudiant en el coneixement i ús de les eines bàsiques del saber d'acord amb el mètode científic. L'assignatura abordarà els problemes relatius a la investigació als camps de la Biologia i de la Medicina con el mètode matemàtic i, especialment, des de la teoria de probabilitats. [...] Biostatistics and Data Analysis aims to introduce students to the fundamental knowledge and use of basic tools of knowledge according to the scientific method. The course will address issues relating to research in the fields of biology and medicine using mathematical method and especially from probability theory. [...] La asignatura de Bioestadística y Análisis de datos tiene como objetivo fundamental el introducir al estudiante en el conocimiento y uso de las herramientas básicas del saber de acuerdo con el método científico. [...]
2018-19 Grau en Ciències Biomèdiques [832]
3 documentos
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