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Depósito Digital de Documentos de la UAB Encontrados 7 registros  La búsqueda tardó 0.01 segundos. 
1.
14 p, 6.4 MB ATR is required to complete meiotic recombination in mice / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rojas, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fuentes Lazaro, Judit (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas) ; Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622  
Registro completo - Creative Commons
2.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo Ècija, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
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3.
13 p, 6.6 MB Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination / Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ; Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ; Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961  
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4.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
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5.
12 p, 6.3 MB Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells / Churchman, Michelle L. (Howard Hughes Medical Institute (Memphis, Estats Units d'Amèrica)) ; Roig, Ignasi, (Ignasi) dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Howard Hughes Medical Institute (Memphis, Estats Units d'Amèrica)) ; Sherr, Charles J. (Howard Hughes Medical Institute (Memphis, Estats Units d'Amèrica))
The mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins (p16Ink4a and p19Arf) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53 transcription factor in response to oncogenic stress. [...]
2011 - 10.1371/journal.pgen.1002157
PLoS Genetics, Vol. 7, Issue 7 (July 2011) , p. e1002157  
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6.
28 p, 2.9 MB Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase / Wojtasz, Lukasz (Technische Universität Dresden. Institute of Physiological Chemistry (Dresden, Alemanya)) ; Daniel, Katrin (Technische Universität Dresden. Institute of Physiological Chemistry (Dresden, Alemanya)) ; Roig, Ignasi, (Ignasi) dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bolcun-Filas, Ewelina (Cornell University (Nova York, Estats Units d'Amèrica)) ; Xu, Huiling (Peter MacCallum Cancer Centre (Melbourne, Austràlia)) ; Boonsanay, Verawan (Technische Universität Dresden. Institute of Physiological Chemistry (Dresden, Alemanya)) ; Eckmann, Christian R. (Max Planck Institute of Molecular Cell Biology and Genetics (Dresden, Alemanya)) ; Cooke, Howard J. (Western General Hospital (Edimburg, Escòcia)) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; McKay, Michael J. (Australian National University. Department of Radiation Oncology (Austràlia)) ; Toth, Attila (Technische Universität Dresden. Institute of Physiological Chemistry (Dresden, Alemanya))
Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic HORMA-domain proteins are required to direct DSB repair towards homologues. [...]
2009 - 10.1371/journal.pgen.1000702
PLoS Genetics, Vol. 5, N. 10 (October 2009) , p. e1000702  
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7.
17 p, 866.2 KB ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes / Barchi, Marco (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi, (Ignasi) dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Di Giacomo, Monica (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; De Rooij, Dirk G.. (Utrecht University. Department of Endocrinology and Metabolism (Països Baixos)) ; Keeney, Scott (Cornell University. Weill Graduate School of Medical Sciences (Nova York, Estats Units d'Amèrica)) ; Jasin, Maria (Cornell University. Weill Graduate School of Medical Sciences (Nova York, Estats Units d'Amèrica))
During meiosis in most sexually reproducing organisms, recombination forms crossovers between homologous maternal and paternal chromosomes and thereby promotes proper chromosome segregation at the first meiotic division. [...]
2008 - 10.1371/journal.pgen.1000076
PLoS Genetics, Vol. 4, Issue 5 (May 2008) , p. e1000076  
Registro completo - Creative Commons

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