|
1.
|
|
812.9 KB |
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
/
Moon, Katherine L. (University of California. Department of Ecology and Evolutionary Biology) ;
Huson, Heather J. (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ;
Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Wang, Ming-Shan (University of California. Howard Hughes Medical Institute) ;
Li, Xue (Broad Institute of MIT and Harvard) ;
Srikanth, Krishnamoorthy (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Svenson, Gavin J. (Cleveland Museum of Natural History) ;
Karlsson, Elinor K. (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Shapiro, Beth (University of California. Department of Ecology and Evolutionary Biology)
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. [...]
2023 -  10.1126/science.abn5887
Science, Vol. 380 Num. 6643 (April 2023) , art. eabn5887
|
|
|
2.
|
|
0 p, 943.5 KB |
The contribution of historical processes to contemporary extinction risk in placental mammals
/
Wilder, Aryn P. (San Diego Zoo Wildlife Alliance. Conservation Genetics) ;
Supple, Megan A. (University of California. Department of Ecology and Evolutionary Biology) ;
Subramanian, Ayshwarya (Broad Institute of MIT and Harvard) ;
Mudide, Anish (Phillips Exeter Academy) ;
Swofford, Ross (Broad Institute of MIT and Harvard) ;
Serres-Armero, Aitor (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Steiner, Cynthia (San Diego Zoo Wildlife Alliance. Conservation Genetics) ;
Koepfli, Klaus-Peter (Smithsonian Conservation Biology Institute) ;
Genereux, Diane P. (Broad Institute of MIT and Harvard) ;
Karlsson, Elinor K. (University of Massachusetts Medical School) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Muñoz-Fuentes, Violeta (European Molecular Biology Laboratory-European Bioinformatics Institute. Wellcome Genome Campus) ;
Foley, Kathleen (Lehigh University. Department of Biological Sciences) ;
Meyer, Wynn K. (Lehigh University, Department of Biological Sciences) ;
Ryder, Oliver A. (University of California. Department of Evolution, Behavior and Ecology) ;
Shapiro, Beth (University of California. Howard Hughes Medical Institute)
Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. Here, we surveyed genetic variation across single genomes of 240 mammals comprising the Zoonomia alignment to evaluate how historical effective population size (N ) impacts heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. [...]
2023 - 10.1126/science.abn5856
Science, Vol. 380, Num. 6643 (April 2023) , art. eabn5856
|
|
|
3.
|
|
7 p, 1.4 MB |
The Earth BioGenome Project 2020: Starting the clock
/
Lewin, Harris A. (University of California Davis. Department of Evolution and Ecology (USA)) ;
Richards, Stephen (University of California Davis. Genome Center) ;
Aiden, Erez (Baylor College of Medicine) ;
Allende, Miguel L. (Universidad de Chile. Center for Genome Regulation) ;
Archibald, John M. (Dalhousie University. Department of Biochemistry & Molecular Biology) ;
Bálint, Miklós M. (Senckenberg Leibniz Institution for Biodiversity and Earth System Research. LOEWE Centre of Translational Biodiversity Genomics) ;
Barker, Katharine M. (Smithsonian Institution. National Museum of Natural History) ;
Baumgartnerk, Bridget (Revive & Restore (USA)) ;
Belov, Katherine (University of Sydney. School of Life and Environmental Sciences) ;
Bertorelle, Giorgio (University of Ferrara. Department of Life Sciences and Biotechnology) ;
Blaxter, Mark (Wellcome Sanger Institute (Cambridge)) ;
Cai, Jing (Northwestern Polytechnical University. School of Ecology and Environment (China)) ;
Caperello, Nicolette (University of California Davis. Genome Center) ;
Carlson, Keith (University of California Santa Barbara) ;
Castilla-Rubio, Juan Carlos (Spacetime Ventures (Brazil)) ;
Chaw, Shu-Miaw (Academia Sinica. Biodiversity Research Center (Taiwan)) ;
Chen, Lei (Northwestern Polytechnical University. School of Ecology and Environment (China)) ;
Childers, Anna K. (US Department of Agriculture. Beltsville Agricultural Research Center) ;
Coddington, Jonathan A. (Smithsonian Institution. National Museum of Natural History) ;
Conde, Dalia A. (University of Southern Denmark. Department of Biology) ;
Corominas, Montserrat (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Crandall, Keith A. (George Washington University. Department of Biostatistics & Bioinformatics) ;
Crawford, Andrew J. (Universidad de los Andes. Department of Biological Sciences (Colombia)) ;
Di Palma, Federica (Genome British Columbia (Vancouver)) ;
Durbin, Richard (University of Cambridge. Department of Genetics) ;
Ebenezer, ThankGod E. (Wellcome Genome Campus. European Bioinformatics Institute) ;
Edwards, Scott (Harvard University. Department of Organismic and Evolutionary Biology) ;
Fedrigo, Olivier (The Rockefeller University. Laboratory of the Neurogenetics of Language (USA)) ;
Flicek, Paul (Wellcome Trust Sanger Institute (Regne Unit)) ;
Formenti, Giulio (The Rockefeller University. Vertebrate Genome Lab (USA)) ;
Gibbs, Richard A. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Gilbert, M. Thomas P. (University of Copenhagen. The GLOBE Institute) ;
Goldstein, Melissa M. (George Washington University. Department of Health Policy and Management) ;
Marshall Graves, Jennifer A. (University of Canberra. Institute for Applied Ecology) ;
Greely, Henry (Stanford University. Stanford Law School) ;
Grigoriev, Igor (United States. Department of Energy. Joint Genome Institute) ;
Hackett, Kevin J. (United States. Department of Agriculture. Agricultural Research Service) ;
Hall, Neil (Norwich Research Park. Earlham Institute (UK)) ;
Haussler, David (University of California Santa Cruz. Genome Institute (USA)) ;
Helgen, Kristofer M. (Australian Museum Research Institute) ;
Hogg, Carolyn J. (University of Sydney. School of Life and Environmental Sciences) ;
Isobe, Sachiko (Kazusa DNA Research Institute. Department of Frontier Research and Development) ;
Jakobsen, Kjetill Sigurd (University of Oslo. Department of Biosciences) ;
Janke, Axel (Senckenberg Leibniz Institution for Biodiversity and Earth System Research. LOEWE Centre of Translational Biodiversity Genomics) ;
Jarvis, Erich (The Rockefeller University. Laboratory of the Neurogenetics of Language (USA)) ;
Johnson, Warren E. (Smithsonian Conservation Biology Institute) ;
Jones, Steven J. M. (Canada's Michael Smith Genome Sciences Centre) ;
Karlsson, Elinor K. (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Kersey, Paul J. (Royal Botanic Gardens Kew) ;
Kim, Jin-Hyoung (Korea Polar Research Institute. Division of Life Sciences) ;
Kress, W. John (Smithsonian Institution. National Museum of Natural History) ;
Kuraku, Shigehiro (National Institute of Genetics. Department of Genomics and Evolutionary Biology) ;
Lawniczak, Mara K. N. (Wellcome Sanger Institute (Cambridge)) ;
Leebens-Mack, James H. (University of Georgia. Department of Plant Biology) ;
Li, Xueyan (Chinese Academy of Sciences. Kunming Institute of Zoology) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Liu, Xin (Beijing Genomics Institute-Shenzhen) ;
Lopez, Jose V. (Nova Southeastern University. Department of Biological Sciences) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Mazard, Sofhie (Macquarie University. Bioplatforms Australia) ;
Mazet, Jonna (University of California Davis. One Health Institute) ;
Mazzoni, Camila J. (Berlin Center for Genomics in Biodiversity Research) ;
Myers, Eugene W. (Max Planck Institute of Molecular Cell Biology and Genetics (Germany)) ;
O'Neill, Rachel J. (University of Connecticut. Institute for Systems Genomics) ;
Paez, Sadye (The Rockefeller University. Laboratory of the Neurogenetics of Language (USA)) ;
Park, Hyun (Korea University. Division of Biotechnology) ;
Robinson, Gene (University of Illinois at Urbana−Champaign. Department of Entomology) ;
Roquet, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Ryder, Oliver A (University of California San Diego. Department of Evolution, Behavior, and Ecology (USA)) ;
Sabir, Jamal S. M. (King Abdulaziz University. Department of Biological Sciences (Saudi Arabia)) ;
Shaffer, Howard Bradley (University of California, Los Angeles. Department of Ecology and Evolutionary Biology) ;
Shank, Timothy M. (Woods Hole Oceanographic Institution) ;
Sherkow, Jacob S. (University of Illinois at Urbana−Champaign. Department of Entomology) ;
Soltis, Pamela (University of Florida. Florida Museum of Natural History) ;
Tang, Boping (Yancheng Teachers University. School of Wetlands (China)) ;
Tedersoo, Leho (University of Tartu. Center of Mycology and Microbiology) ;
Uliano da Silva, Marcela (Wellcome Sanger Institute (Cambridge)) ;
Wang, Kun (Northwestern Polytechnical University. School of Ecology and Environment (China)) ;
Wei, Xiaofeng (Beijing Genomics Institute-Shenzhen) ;
Wetzer, Regina (University of Southern California, Los Angeles. Biological Sciences) ;
Wilson, Julia L. (Wellcome Sanger Institute (Cambridge)) ;
Xu, Xun (Beijing Genomics Institute-Shenzhen) ;
Yang, Huanming (Beijing Genomics Institute-Shenzhen) ;
Yoder, Anne (Duke University, Durham. Department of Biology) ;
Zhang, Guojie (Beijing Genomics Institute-Shenzhen)
2022 - 10.1073/pnas.2115635118
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Num. 4 (2022) , art. e2115635118
|
|
|
4.
|
|
28 p, 5.4 MB |
BarkBase : Epigenomic Annotation of Canine Genomes
/
Megquier, Kate (Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge.) ;
Genereux, Diane P. (Broad Institute of MIT and Harvard) ;
Hekman, Jessica (Broad Institute of MIT and Harvard) ;
Swofford, Ross (Broad Institute of MIT and Harvard) ;
Turner-Maier, Jason (Broad Institute of MIT and Harvard) ;
Johnson, Jeremy (Broad Institute of MIT and Harvard) ;
Alonso, Jacob (Broad Institute of MIT and Harvard) ;
Li, Xue (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Anguish, Lynne J. (Cornell University. Baker Institute for Animal Health) ;
Koltookian, Michele (Broad Institute of MIT and Harvard) ;
Logan, Brittney (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Sharp, Claire R. (Murdoch University. School of Veterinary and Life Sciences) ;
Ferrer i Caubet, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Meyers-Wallen, Vicki N. (Cornell University. Baker Institute for Animal Health) ;
Hoffman, Andrew (Tufts University. Cummings School of Veterinary Medicine) ;
Karlsson, Elinor K. (University of Massachusetts Medical School. Program in Molecular Medicine)
Dogs are an unparalleled natural model for investigating the genetics of health and disease, particularly for complex diseases like cancer. Comprehensive genomic annotation of regulatory elements active in healthy canine tissues is crucial both for identifying candidate causal variants and for designing functional studies needed to translate genetic associations into disease insight. [...]
2019 - 10.3390/genes10060433
Genes, Vol. 10 (june 2019)
|
|
visitante ::
identificación
alerta personal vía correo electrónico o subscríbase al 
canal RSS.
