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10 p, 2.9 MB Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions / Arimany-Nardi, Cristina (Oncology Program, National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ; Minuesa, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Keller, Thorsten (Department of Pharmacology, School of Medicine, University of Würzburg) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Koepsell, Hermann (Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pastor-Anglada, Marçal (Institut de Recerca Pediàtrica Hospital Sant Joan de Déu) ; Universitat Autònoma de Barcelona
Lamivudine (3TC), a drug used in the treatment of HIV infection, needs to cross the plasma membrane to exert its therapeutic action. Human Organic cation transporter 1 (hOCT1), encoded by the SLC22A1 gene, is the transporter responsible for its uptake into target cells. [...]
2016 - 10.3389/fphar.2016.00175
Frontiers in Pharmacology, Vol. 7 (june 2016)  

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