Klughammer, B - Resultados de la búsqueda - Depósito Digital de Documentos de la UAB

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8 p, 334.2 KB

Clinical Validation of a PCR Assay for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer : Retrospective Testing of Specimens from the EURTAC Trial / Benlloch, Susana (Pangaea Biotech) ; Botero, Maria Luisa (Pangaea Biotech) ; Beltran-Alamillo, Jordi (Pangaea Biotech) ; Mayo, Clara (Pangaea Biotech) ; Giménez-Capitán, Ana (Pangaea Biotech) ; de Aguirre, Itziar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Queralt, C (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramirez, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Klughammer, Barbara (F. Hoffmann-La Roche, Basel) ; Schlegel, Mariette (F. Hoffmann-La Roche, Basel) ; Bordogna, Walter (F. Hoffmann-La Roche, Basel) ; Chen, David (Genentech, South San Francisco, California) ; Zhang, Guili (Roche Molecular Systems, Pleasanton, California) ; Kovach, Barbara (Roche Molecular Systems, Pleasanton, California) ; Shieh, Felice (Roche Molecular Systems, Pleasanton, California) ; Palma, John F. (Roche Molecular Systems, Pleasanton, California) ; Wu, Lin (Roche Molecular Systems, Pleasanton, California) ; Lawrence, H. Jeffrey (Roche Molecular Systems, Pleasanton, California) ; Taron, Miquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The EURTAC trial demonstrated that the tyrosine kinase inhibitor (TKI) erlotinib was superior to chemotherapy as first-line therapy for advanced non-small cell lung cancers (NSCLC) that harbor EGFR activating mutations in a predominantly Caucasian population. [...]
2014 - DOI (Digital Object Identifier)

10.1371/journal.pone.0089518
PloS one, Vol. 9 (february 2014)

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6 p, 263.8 KB

A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer / Tan, E. H. (National Cancer Centre (Singapur). Department of Medical Oncology) ; Ramlau, Rodryg (Regional Lung Disease Centre (Poznan). Department of Oncology) ; Pluzanska, A. (Regional Oncology Centre (Lodz, Polònia). Oncological Chemotherapy Clinic) ; Kuo, H. -P. (Chang Gung Memorial Hospital (Linkou, Taiwan). Department of Thoracic Medicine) ; Reck, Martin (Hospital Grosshansdorf (Grosshansdorf, Alemanya). Department of Thoracic Oncology) ; Milanowski, J. (Akademia Medyczna w Lublinie (Lublin, Polònia). Department of Pneumology, Oncology and Allergology) ; Au, J. S. -K. (Queen Elizabeth Hospital (Hong Kong). Department of Clinical Oncology) ; Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ; Yang, P. -C. (National Taiwan University Hospital (Taipei, Taiwan)) ; Damyanov, D. (Specialized Hospital for Active Treatment in Oncology (Sofia, Bulgaria)) ; Orlov, S. (Pavlov State Medical University. Research Institute of Pulmonology (Sant Petersburg, Rússia)) ; Akimov, Mikhail (Hoffmann-La Roche (Basel, Suïssa)) ; Delmar, P. (Hoffmann-La Roche (Basel, Suïssa)) ; Essioux, L. (Hoffmann-La Roche (Basel, Suïssa)) ; Hillenbach, C. (Hoffmann-La Roche (Basel, Suïssa)) ; Klughammer, B. (Hoffmann-La Roche (Basel, Suïssa)) ; McLoughlin, P. (Hoffmann-La Roche (Basel, Suïssa)) ; Baselga Torres, Josep, 1959-2021, (Hospital Universitari Vall d'Hebron)
Background: Identification of appropriate markers for predicting clinical benefit with erlotinib in non-small-cell lung cancer (NSCLC) may be able to guide patient selection for treatment. This open-label, multicentre, phase II trial aimed to identify genes with potential use as biomarkers for clinical benefit from erlotinib therapy. [...]
2010
Annals of oncology, Vol. 21, Issue 2 (2010) , p. 217-222

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