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17 p, 693.0 KB |
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas ;
Xu, Huichun ;
Gaynor, Brady ;
Cole, John W. ;
Rannikmae, Kristiina ;
Stanne, Tara M. ;
Tomppo, Liisa ;
Abedi, Vida ;
Amouyel, Philippe ;
Armstrong, Nicole D. ;
Attia, John ;
Bell, Steven ;
Benavente, Oscar R. ;
Boncoraglio, Giorgio B. ;
Butterworth, Adam ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Zhengming ;
Chong, Michael ;
Cruchaga, Carlos ;
Cushman, Mary ;
Danesh, John ;
Debette, Stéphanie ;
Duggan, David J. ;
Durda, Jon Peter ;
Engstrom, Gunnar ;
Enzinger, Chris ;
Faul, Jessica D. ;
Fecteau, Natalie S. ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Gieger, Christian ;
Giese, Anne-Katrin ;
Grewal, Raji P. ;
Grittner, Ulrike ;
Havulinna, Aki S. ;
Heitsch, Laura ;
Hochberg, Marc C. ;
Holliday, Elizabeth ;
Hu, Jie ;
Ilinca, Andreea ;
Irvin, Marguerite R. ;
Jackson, Rebecca D. ;
Jacob, Mina A. ;
Rabionet, Raquel ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Johnson, Julie A. ;
Kamatani, Yoichiro ;
Kardia, Sharon L.R. ;
Koido, Masaru ;
Kubo, Michiaki ;
Lange, Leslie ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Levi, Christopher R. ;
Li, Jiang ;
Li, Liming ;
Lin, Kuang ;
Lopez, Haley ;
Luke, Sothear ;
Maguire, Jane ;
McArdle, Patrick F. ;
McDonough, Caitrin W. ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Metso, Tiina ;
Müller-Nurasyid, Martina ;
Dichgans, Martin ;
O'Donnell, Martin ;
Peddareddygari, Leema R. ;
Pera, Joanna ;
Perry, James A. ;
Peters, Annette ;
Putaala, Jukka ;
Ray, Debashree ;
Rexrode, Kathryn ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosand, Jonathan ;
Rothwell, Peter M. ;
Rundek, Tatjana ;
Ryan, Kathleen A. ;
Sacco, Ralph L. ;
Salomaa, Veikko ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schmidt, Reinhold ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Smith, Jennifer A. ;
Smith, Nicholas L. ;
Wassertheil-Smoller, Sylvia ;
Söderholm, Martin ;
Stine, O. Colin ;
Strbian, Daniel ;
Sudlow, Cathie L.M. ;
Tatlisumak, Turgut ;
Terao, Chikashi ;
Thijs, Vincent ;
Torres-Aguila, Nuria P.. ;
Trégouët, David-Alexandre ;
Tuladhar, Anil M. ;
Veldink, Jan ;
Walters, Robin G. ;
Weir, David R. ;
Woo, Daniel ;
Worrall, Bradford B. ;
Hong, Charles C. ;
Ross, Owen A. ;
Zand, Ramin ;
de Leeuw, Frank-Erik ;
Lindgren, Arne G. ;
Paré, Guillaume ;
Anderson, Christopher D. ;
Markus, Hugh S. ;
Jern, Christina ;
Malik, Rainer ;
Dichgans, Martin ;
Mitchell, Braxton D. ;
Kittner, Steven J. ;
Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 -  10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754
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9 p, 990.5 KB |
International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
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Lindgren, Arne G. (Skåne University Hospital (Suècia)) ;
Braun, Robynne G. (Department of Neurology, University of Maryland) ;
Juhl Majersik, Jennifer (Department of Neurology, University of Utah) ;
Clatworthy, Philip (North Bristol NHS Trust) ;
Mainali, Shraddha (The Ohio State University) ;
Derdeyn, Colin P. (University of Iowa) ;
Maguire, Jane (University of Technology Sydney) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Cole, John W. (University of Maryland School of Medicine) ;
Lee, Jin-Moo (Washington University School of Medicine, St. Louis) ;
Khatri, Pooja (University of Cincinnati) ;
Nyquist, Paul (Johns Hopkins School of Medicine, Baltimore) ;
Debette, Stéphanie (Bordeaux University Hospital (França)) ;
Keat Wei, Loo (Universiti Tunku Abdul Rahman, Perak) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Leifer, Dana (Weill Cornell Medicine, New York) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Melbourne) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Heitsch, Laura (Washington University School of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Jimenez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Dichgans, Martin (Institute for Stroke and Dementia Research (Munic, Alemanya)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Cramer, Steven C. (California Rehabilitation Institute) ;
Bernhardt, Julie (Florey Institute of Neuroscience and Mental Health (Melbourne, Austràlia)) ;
Worrall, Bradford B. (University of Virginia) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. [...]
2021 - 10.1177/17474930211007288
International Journal of Stroke, Vol. 17 (april 2021) , p. 260-268
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14 p, 236.7 KB |
Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke : A Systematic Review
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Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, Jonathan (Institut d'Investigació Biomèdica Sant Pau) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Krupinski, Jerzy (The Manchester Metropolitan University of All Saints. Health Care Science Department) ;
Montaner, Joan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Cruchaga, Carlos (Washington University School of Medicine. Department of Psychiatry) ;
Lee, Jin-Moo (Washington University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. [...]
2019 - 10.5853/jos.2019.01522
Journal of Stroke, Vol. 21 (september 2019) , p. 276-289
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13 p, 1.4 MB |
Genome-wide association meta-analysis of functional outcome after ischemic stroke
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Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Pedersen, Annie (Department of Clinical Neuroscience. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg) ;
Lorentzen, Erik (Sahlgrenska University Hospital (Suècia)) ;
Stanne, Tara M. (Institute of Biomedicine) ;
Bevan, Steve (Bioinformatics Core Facility. University of Gothenburg) ;
Olsson, Maja (Institute of Biomedicine) ;
Cole, John W. ;
Fernandez-Cadenas, Israel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Hankey, Graeme J. (Medical School. The University of Western Australia, Perth; Department of Neurology) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jood, Katarina (Department of Clinical Genetics and Genomics) ;
Lee, Jin-Moo (Department of Neurology. Washington University School of Medicine, St. Louis, MO) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R (School of Medicine and Public Health) ;
Mitchell, Braxton D. (Priority Research Centre for Stroke and Traumatic Brain Injury. University of Newcastle) ;
Norrving, Bo (Skåne University Hospital (Suècia)) ;
Rannikmäe, Kristiina (University of Maryland. Department of Medicine) ;
Rost, Natalia S. (Geriatric Research. Education. and Clinical Center. Veterans Affairs Medical Center) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Rothwell, Peter M. (Broad Institute of MIT and Harvard) ;
Scott, Rodney (University of Virginia. Departments of Neurology and Health Evaluation Sciences) ;
Strbian, Daniel (Massachusetts General Hospital (Boston)) ;
Sturm, Jonathan W. (VIB. Center for Brain and Disease Research) ;
Sudlow, Cathie (University of Maryland. Department of Medicine) ;
Traylor, Matthew (University of Oxford. Nuffield Department of Clinical Neurosciences.) ;
Thijs, Vincent (University of Cambridge. Department of ClinicalNeurosciences) ;
Tatlisumak, Turgut (Stroke Division. Florey Institute for Neuroscience and Mental Health. University of Melbourne) ;
Woo, Daniel (Austin Health. Department of Neurology) ;
Worrall, Bradford B. (University of Cincinnati. Department of Neurology and Rehabilitation) ;
Maguire, Jane M. (HunterMedical Research Centre. PRC Stroke and Brain Injury) ;
Lindgren, Arne (Skåne University Hospital (Suècia)) ;
Jern, Christina (University of Lincoln. School of Life Sciences) ;
Universitat Autònoma de Barcelona
ObjectiveTo discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. MethodsThe study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. [...]
2019 - 10.1212/WNL.0000000000007138
Neurology, Vol. 92 Núm. 12 (19 2019) , p. E1271-E1283
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8 p, 2.3 MB |
Automated quantification of cerebral edema following hemispheric infarction : Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs
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Chen, Yasheng (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ;
Dhar, Rajat (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ;
Heitsch, Laura (Emergency Medicine, Washington University, St. Louis, MO 63110, USA) ;
Ford, Andria (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lin, Weili (Dept. of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA) ;
Shen, Dinggang (Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea) ;
An, Hongyu (Radiology, Washington University, St. Louis, MO 63110, USA) ;
Lee, Jin-Moo (Biomedical Engineering, Washington University, St. Louis, MO 63110, USA) ;
Universitat Autònoma de Barcelona
Although cerebral edema is a major cause of death and deterioration following hemispheric stroke, there remains no validated biomarker that captures the full spectrum of this critical complication. We recently demonstrated that reduction in intracranial cerebrospinal fluid (CSF) volume (∆ CSF) on serial computed tomography (CT) scans provides an accurate measure of cerebral edema severity, which may aid in early triaging of stroke patients for craniectomy. [...]
2016 - 10.1016/j.nicl.2016.09.018
NeuroImage, Vol. 12 (september 2016) , p. 673-680
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