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39 p, 2.5 MB Peroxynitrite formed during a transient episode of brain ischemia increases endothelium-derived hyperpolarization-type dilations in thromboxane/prostaglandin receptor-stimulated rat cerebral arteries / Onetti Vilalta, Yara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dantas, A. P. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pérez, Belén (Universitat Autònoma de Barcelona. Institut de Neurociències) ; McNeish, Alister J. (University of Reading. Reading School of Pharmacy) ; Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Institut de Neurociències)
AIM: Increased thromboxane A2 and peroxynitrite are hallmarks of cerebral ischaemia/reperfusion (I/R). Stimulation of thromboxane/prostaglandin receptors (TP) attenuates endothelium-derived hyperpolarization (EDH). [...]
2016 - 10.1111/apha.12809
Acta Physiologica, Vol. 220, no. 1 (September 2016) , p. 150-166
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11 p, 695.0 KB Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (KCa2.3) in cerebral arteries / McNeish, Alister J. (University of Reading. Reading School of Pharmacy) ; Jiménez Altayó, Francesc (University of Oxford. Department of Pharmacology) ; Cottrell, Graeme S. (University of Bath. Department pf Pharmacy and Pharmacology) ; Garland, Christopher J. (University of Oxford. Department of Pharmacology)
Background: In rat middle cerebral and mesenteric arteries the KCa2. 3 component of endothelium-dependent hyperpolarization (EDH) is lost following stimulation of thromboxane (TP) receptors, an effect that may contribute to the endothelial dysfunction associated with cardiovascular disease. [...]
2012 - 10.1371/journal.pone.0046735
PloS one, Vol. 7, Issue 10 (October 2012) , p. e46735  
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