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9 p, 2.1 MB ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability / Scheffler, Matthias (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Schultheis, Anne (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Teixidó, Cristina (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Michels, Sebastian (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Morales Espinosa, Daniela (Institut Germans Trias i Pujol) ; Viteri, Santiago (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ; Merkelbach Bruse, Sabine (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Fischer, Rieke (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Schildhaus, Hans Ulrich (University Medical Center of Göttingen (Alemanya)) ; Fassunke, Jana (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Sebastian, Martin (University Hospital of Frankfurt (Alemanya)) ; Serke, Monika (Lung Clinic Hemer (Alemanya)) ; Kaminsky, Britta (Bethanien Hospital (Solingen, Alemanya)) ; Randerath, Winfried (Bethanien Hospital (Solingen, Alemanya)) ; Gerigk, Ulrich (Malteser Hospital Seliger Gerhard Bonn/Rhein-Sieg (Alemanya)) ; Ko, Yon Dschun (Johanniter Hospital (Bonn, Alemanya)) ; Krüger, Stefan (Florence-Nightingale Hospital (Düsseldorf, Alemanya)) ; Schnell, Roland ; Rothe, Achim ; Kropf Sanchen, Cornelia (University Hospital Ulm (Alemanya)) ; Heukamp, Lukas (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Rosell, Rafael (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Büttner, Reinhard (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya)) ; Wolf, Jürgen (Center for Integrated Oncology Köln Bonn (Cologne, Alemanya))
BACKGROUND: While recent data show that crizotinib is highly effective in patients with ROS1 rearrangement, few data is available about the prognostic impact, the predictive value for different treatments, and the genetic heterogeneity of ROS1-positive patients. [...]
2015 - 10.18632/oncotarget.3387
Oncotarget, Vol. 6 Núm. 12 (april 2015)  

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