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15 p, 1.4 MB |
Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis
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Pollak, Thomas A. (King's College London. Department of Psychosis Studies) ;
Kempton, Matthew J. (King's College London. Department of Psychosis Studies) ;
Iyegbe, Conrad (King's College London. Department of Psychosis Studies) ;
Vincent, Angela (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Irani, Sarosh R. (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Coutinho, Ester (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Menassa, David A. (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Jacobson, Leslie (John Radcliffe Hospital (Oxford, Regne Unit)) ;
de Haan, Lieuwe (University of Amsterdam. Department Early Psychosis) ;
Ruhrmann, Stephan (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Sachs, Gabriele (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Riecher-Rössler, Anita (University of Basel. Medical Faculty) ;
Krebs, Marie-Odile (University of Paris. Institut de Psychiatrie) ;
Amminger, Paul (University of Melbourne. Centre for Youth Mental Health) ;
Glenthøj, Birte (University of Copenhagen. Centre for Neuropsychiatric Schizophrenia Research & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research) ;
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
van Os, Jim (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
Rutten, Bart P. F. (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology) ;
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo. Institute for Prevention of Mental Disorders) ;
van der Gaag, Mark (VU University. Department of Clinical Psychology) ;
Yolken, Robert (Johns Hopkins School of Medicine. Department of Pediatrics) ;
Hotopf, Matthew (King's College London. Department of Psychological Medicine) ;
Valmaggia, Lucia (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Stone, James (King's College London. Department of Psychosis Studies) ;
David, Anthony S. (King's College London. Department of Psychosis Studies) ;
McGuire, Philip (King's College London. Department of Psychosis Studies)
Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. [...]
2020 -  10.1038/s41380-020-00899-w
Molecular psychiatry, Vol. 26 (october 2020) , p. 2590-2604
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12 p, 5.0 MB |
Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient
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Saxena, Abhishek (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Stevens, Jo (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Cetin, Hakan (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Koneczny, Inga (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Webster, Richard (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Lazaridis, Konstantinos (Hellenic Pasteur Institute) ;
Tzartos, Socrates (Hellenic Pasteur Institute) ;
Vrolix, Kathleen (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Machiels, Barbie (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Molenaar, Peter C. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Damoiseaux, Jan (Central Diagnostic Laboratory, Maastricht University Medical Center) ;
De Baets, Marc H. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Simon-Keller, Katja (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ;
Marx, Alexander (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ;
Vincent, Angela (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Losen, Mario (Maastricht University. Department of Psychiatry and Neuropsychology) ;
Martinez-Martinez, Pilar (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Universitat Autònoma de Barcelona
We report here the sequence and functional characterization of a recombinantly expressed.
autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the VHCDR2. [...]
2017 - 10.1038/s41598-017-14350-8
Scientific reports, Vol. 7 (october 2017) , p. 1-12
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12 p, 385.6 KB |
Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis
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Lee, Jae-Yun (Yale School of Medicine. Department of Neurology) ;
Stathopoulos, Panos (Yale School of Medicine. Department of Neurology) ;
Gupta, Sasha (Yale School of Medicine. Department of Neurology) ;
Bannock, Jason M. (Yale School of Medicine. Department of Immunobiology) ;
Barohn, Richard J. (University of Kansas Medical Center. Department of Neurology) ;
Cotzomi, Elizabeth (Yale School of Medicine. Department of Neurology) ;
Dimachkie, Mazen M. (University of Kansas Medical Center. Department of Neurology) ;
Jacobson, Leslie (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Lee, Casey S. (Yale School of Medicine. Department of Neurology) ;
Morbach, Henner (Yale School of Medicine. Department of Immunobiology) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Shan, Jing-Li (Yale School of Medicine. Department of Neurology) ;
Vander Heiden, Jason A. (Yale University. Interdepartmental Program in Computational Biology and Bioinformatics) ;
Waters, Patrick (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Vincent, Angela (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Nowak, Richard J. (Yale School of Medicine. Department of Neurology) ;
O'Connor, Kevin C. (Yale School of Medicine. Department of Neurology) ;
Universitat Autònoma de Barcelona
Myasthenia gravis () is an autoimmune condition in which neurotransmission is impaired by binding of autoantibodies to acetylcholine receptors (hR) or, in a minority of patients, to muscle specific kinase (Mu). [...]
2016 - 10.1002/acn3.311
Annals of Clinical and Translational Neurology, Vol. 3, Issue 6 (June 2016) , p. 443-454
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11 p, 1.3 MB |
Multicentre comparison of a diagnostic assay : aquaporin-4 antibodies in neuromyelitis optica
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Waters, Patrick (University of Oxford) ;
Reindl, Markus (Medical University of Innsbruck) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Schanda, Kathrin (Medical University of Innsbruck) ;
Tuller, Friederike (Medical University of Innsbruck) ;
Kral, Vlastimil (Zdravotni ustav se sidlem v Usti nad Labem, Centrum imunologie a mikrobiologie) ;
Nytrova, Petra (Charles University. Faculty of Medicine in Hradec Králové) ;
Sobek, Ondrej (Topelex Ltd) ;
Nielsen, Helle Hvilsted (Odense University Hospital (Dinamarca)) ;
Barington, Torben (Odense University Hospital (Dinamarca)) ;
Lillevang, Søren T. (Odense University Hospital (Dinamarca)) ;
Illes, Zsolt (University of Pécs) ;
Rentzsch, Kristin (Euroimmun AG) ;
Berthele, Achim (Klinikum rechts der Isar der TU München, Klinik für Neurologie) ;
Berki, Tímea (University of Pécs) ;
Granieri, Letizia (Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Regional Referring Multiple Sclerosis Centre) ;
Bertolotto, Antonio (Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Regional Referring Multiple Sclerosis Centre) ;
Giometto, Bruno (Azienda ULSS 9 Treviso) ;
Zuliani, Luigi (Azienda ULSS 9 Treviso) ;
Hamann, Dörte (Sanquin Diagnostic Services, Department of Immunopathology and Blood Coagulation, Amsterdam) ;
van Pelt, E. Daniëlle (MS Centre ErasMS, Erasmus MC) ;
Hintzen, Rogier (MS Centre ErasMS, Erasmus MC) ;
Höftberger, Romana (Medical University of Vienna. Institute of Neurology) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Siva, Aksel (Istanbul University, Cerrahpasa Medical School) ;
Altintas, Ayse (Istanbul University, Cerrahpasa Medical School) ;
Deniz, Günnur (Istanbul University, Institute of Experimental Medicine) ;
Woodhall, Mark (University of Oxford) ;
Palace, Jacqueline (University of Oxford) ;
Paul, Friedemann (Charité - Universitätsmedizin Berlin) ;
Hartung, Hans-Peter (Heinrich-Heine-University Düsseldorf) ;
Aktas, Orhan (Heinrich-Heine-University Düsseldorf) ;
Jarius, Sven (University of Heidelberg) ;
Wildemann, Brigitte (University of Heidelberg) ;
Vedeler, Christian (Haukeland University Hospital (Bergen, Noruega)) ;
Ruiz, Anne (Lyon Neurosciences Research Centre, Neuro-inflammation and Neuro-oncology Team) ;
Leite, M. Isabel (University of Oxford) ;
Trillenberg, Peter (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Probst, Monika (Institute for Quality Assurance) ;
Saschenbrecker, Sandra (Euroimmun AG) ;
Vincent, Angela (University of Oxford) ;
Marignier, Romain (Lyon Neurosciences Research Centre, Neuro-inflammation and Neuro-oncology Team) ;
Universitat Autònoma de Barcelona
Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility. [...]
2016 - 10.1136/jnnp-2015-312601
Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 87 (april 2016) , p. 1005-1015
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