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1.
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25 p, 6.3 MB |
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Arias-Sardá, Cristina (University of Kent. School of Biosciences) ;
Montes-Espuña, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lister, Nicholas C. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Cuartero, Yasmina (Centre de Regulació Genòmica) ;
García, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Deakin, Janine (University of Canberra. Institute for Applied Ecology) ;
Renfree, Marilyn B. (The University of Melbourne. School of Biosciences) ;
Robinson, Terence J. (Stellenbosch University. Department of Botany and Zoology) ;
Martí-Renom, Marc A. (Centre de Regulació Genòmica) ;
Waters, Paul D. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Farré, Marta (University of Kent. School of Biosciences) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. [...]
2022 -  10.1016/j.celrep.2022.111839
Cell reports, Vol. 41, Issue 12 (December 2022) , art. 111839
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2.
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19 p, 4.4 MB |
Divergent patterns of meiotic double strand breaks and synapsis initiation dynamics suggest an evolutionary shift in the meiosis program between American and Australian marsupials
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Valero-Regalón, F. Javier (Universidad Autónoma de Madrid) ;
Solé, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López-Jiménez, Pablo (Universidad Autónoma de Madrid) ;
Valerio-de Arana, María (Universidad Autónoma de Madrid) ;
Martín-Ruiz, Marta (Universidad Autónoma de Madrid) ;
de la Fuente, Roberto (The Polish Academy of Sciences) ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Renfree, Marilyn B. (The University of Melbourne) ;
Shaw, Geoff (The University of Melbourne) ;
Berríos, Soledad (Universidad de Chile) ;
Fernández-Donoso, Raúl (Universidad de Chile) ;
Waters, Paul D. (University of New South Wales) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gómez, Rocío (Universidad Autónoma de Madrid) ;
Page, Jesús (Universidad Autónoma de Madrid)
In eutherian mammals, hundreds of programmed DNA double-strand breaks (DSBs) are generated at the onset of meiosis. The DNA damage response is then triggered. Although the dynamics of this response is well studied in eutherian mammals, recent findings have revealed different patterns of DNA damage signaling and repair in marsupial mammals. [...]
2023 - 10.3389/fcell.2023.1147610
Frontiers in Cell and Developmental Biology, Vol. 11 (April 2023) , art. 1147610
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3.
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8 p, 2.6 MB |
Three dimensions of thermolabile sex determination
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Waters, Paul D. (UNSW Sydney. School of Biotechnology and Biomolecular Science) ;
Graves, Jennifer A.Marshall (University of Canberra. Institute for Applied Ecology) ;
Whiteley, Sarah L. (University of Canberra. Institute for Applied Ecology) ;
Georges, Arthur (University of Canberra. Institute for Applied Ecology) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The molecular mechanism of temperature-dependent sex determination (TSD) is a long-standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. [...]
2023 - 10.1002/bies.202200123
BioEssays, Vol. 45, Issue 2 (February 2023) , art. 2200123
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4.
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15 p, 3.8 MB |
Meiotic chromosome dynamics and double strand break formation in reptiles
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Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González Rodelas, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
M. Garcias, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kratochvíl, Lukáš (Charles University. Department of Ecology) ;
Valenzuela, Nicole (Iowa State University. Department of Ecology) ;
Georges, Arthur (University of Canberra) ;
Waters, Paul D. (UNSW. Faculty of Science) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes. [...]
2022 - 10.3389/fcell.2022.1009776
Frontiers in Cell and Developmental Biology, Vol. 10 (october 2022)
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5.
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11 p, 1.4 MB |
Microchromosomes are building blocks of bird, reptile, and mammal chromosomes
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Waters, Paul D. (UNSW Sydney. School of Biotechnology and Biomolecular Science) ;
Patel, Hardip R. (Australian National University. The John Curtin School of Medical Research) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Lister, Nicholas C. (UNSW Sydney. School of Biotechnology and Biomolecular Science) ;
Simakov, Oleg (University of Vienna. Department of Neurosciences and Developmental Biology) ;
Ezaz, Tariq (University of Canberra. Institute for Applied Ecology) ;
Kaur, Parwinder (The University of Western Australia. UWA School of Agriculture and Environment) ;
Frere, Celine (University of the Sunshine Coast (Australia)) ;
Grutzner, Frank (University of Adelaide. School of Biological Sciences (Australia)) ;
Georges, Arthur (University of Canberra. Institute for Applied Ecology) ;
Marshall Graves, Jennifer A. (La Trobe University. School of Life Sciences (Australia))
Microchromosomes, once considered unimportant shreds of the chicken genome, are gene-rich elements with a high GC content and few transposable elements. Their origin has been debated for decades. We used cytological and whole-genome sequence comparisons, and chromosome conformation capture, to trace their origin and fate in genomes of reptiles, birds, and mammals. [...]
2021 - 10.1073/pnas.2112494118
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 45 (November 2021) , art. e2112494118
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7.
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26 p, 4.3 MB |
Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials
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Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
González Rodelas, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pujol Infantes, Gala (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín-Ruiz, Marta (Universidad Autónoma de Madrid. Departamento de Biología) ;
Berríos, Soledad (Universidad de Chile. Programa de Genética Humana) ;
Fernández-Donoso, Raúl (Universidad de Chile. Programa de Genética Humana) ;
Pask, Andrew (The University of Melbourne. School of BioSciences) ;
Renfree, Marilyn B. (The University of Melbourne. School of BioSciences) ;
Page, Jesús (Universidad Autónoma de Madrid. Departamento de Biología) ;
Waters, Paul D. (School of Biotechnology and Biomolecular Sciences) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
During meiotic prophase I, homologous chromosomes pair, synapse and recombine in a tightly regulated process that ensures the generation of genetically variable haploid gametes. Although the mechanisms underlying meiotic cell division have been well studied in model species, our understanding of the dynamics of meiotic prophase I in non-traditional model mammals remains in its infancy. [...]
2022 - 10.1371/journal.pgen.1010040
PLoS Genetics, Vol. 18, Issue 2 (February 2022) , art. e1010040
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8.
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26 p, 7.4 MB |
Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis
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Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Paytuví-Gallart, Andreu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cuartero, Yasmina (Centre de Regulació Genòmica) ;
Le Dily, François (Centre de Regulació Genòmica) ;
García, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Salvà Castro, Judith (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gomez Hernández, Laura (Centro de Investigación del Cáncer) ;
Julià, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Moutinho, Catia (Centre de Regulació Genòmica) ;
Aiese Cigliano, Riccardo (Sequentia Biotech) ;
Sanseverino, Walter (Sequentia Biotech) ;
Fornas, Òscar (Centre de Regulació Genòmica) ;
Martín Pendas, Alberto (Centro de Investigación del Cáncer) ;
Heyn, Holger (Centre de Regulació Genòmica) ;
Waters, Paul D. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Martí Renom, Marc A. (Centre de Regulació Genòmica) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) of CCCTC-binding factor (CTCF) and meiotic cohesins, coupled with confocal and super-resolution microscopy. [...]
2019 - 10.1016/j.celrep.2019.06.037
Cell reports, Vol. 28, issue 2 (Jul. 2019) , p. 352-367
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