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20 p, 745.4 KB |
Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach
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Bosch Camós, Laia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Navas, María Jesús (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pina-Pedrero, Sonia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Accensi Alemany, Francesc (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Correa-Fiz, Florencia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Park, Chankyu (Konkuk University. Department of Stem Cells and Regenerative Biology) ;
Carrascal Pérez, Montserrat (Instituto de Investigaciones Biomédicas de Barcelona) ;
Domínguez, Javier (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Biotecnología) ;
Salas, María Luisa (Centro de Biología Molecular Severo Ochoa) ;
Nikolin, Veljko (Boehringer Ingelheim Veterinary Research Center) ;
Collado Miguens, Javier Alonso (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodriguez, Fernando (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
López Fernandez, Elisabet (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
The development of subunit vaccines against African swine fever (ASF) is mainly hindered by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in protection. As a good example, the identity of ASFV-specific CD8+ T-cell determinants remains largely unknown, despite their protective role being established a long time ago. [...]
2021 -  10.3390/vaccines9010029
Vaccines (Basel), Vol. 9 Núm. 1 (2021) , p. 29
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14 p, 3.2 MB |
Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8 + T Cells and Evolve at the Population Level
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Karimzadeh, Hadi (Department of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany) ;
Kiraithe, Muthamia M. (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Oberhardt, Valerie (Faculty of Biology, University of Freiburg, Freiburg, Germany) ;
Salimi Alizei, Elahe (Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany) ;
Bockmann, Jan (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Schulze zur Wiesch, Julian (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Budeus, Bettina (Department of Bioinformatics, University of Duisburg-Essen, Essen, Germany) ;
Hoffmann, Daniel (Department of Bioinformatics, University of Duisburg-Essen, Essen, Germany) ;
Wedemeyer, Heiner (University Hospital Essen (Alemanya)) ;
Cornberg, Markus (Hannover Medical School. Department of Gastroenterology, Hepatology and Endocrinology) ;
Krawczyk, Adalbert (Department of Infectious Diseases, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany) ;
Rashidi-Alavijeh, Jassin (University Hospital Essen (Alemanya)) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Smedile, Antonina (Department of Medical Sciences, University of Turin, Turin, Italy) ;
Alavian, Seyed Moayed (Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran) ;
Heinold, Andreas (University Hospital Essen (Alemanya)) ;
Emmerich, Florian (Institute for Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Panning, Marcus (Institute of Virology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Gostick, Emma (Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom) ;
Price, David A. (Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom) ;
Timm, Jörg (Institute of Virology, Heinrich-Heine-University, University Hospital, Duesseldorf, Germany) ;
Hofmann, Maike (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Raziorrouh, Bijan (Department of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany) ;
Thimme, Robert (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Protzer, Ulrike (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Roggendorf, Michael (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Neumann-Haefelin, Christoph (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Universitat Autònoma de Barcelona
Hepatitis D virus (HDV) superinfection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. [...]
2019 - 10.1053/j.gastro.2019.02.003
Gastroenterology, Vol. 156 (may 2019) , p. 1820-1833
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5 p, 190.8 KB |
In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction
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Silva-Arrieta, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Goulder, Phillip J. R. (Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America) ;
Brander, Christian. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
2020 - 10.1371/journal.ppat.1008607
PLOS pathogens, Vol. 16 Núm. 6 (january 2020) , p. e1008607
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14 p, 6.3 MB |
CD40-activated B cells induce anti-tumor immunity in vivo
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Wennhold, Kerstin (Uniklinik Köln (Colònia, Alemanya)) ;
Weber, Tanja M. (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany) ;
Klein-Gonzalez, Nela (Hospital Universitari Vall d'Hebron) ;
Thelen, Martin (Uniklinik Köln (Colònia, Alemanya)) ;
Garcia-Marquez, Maria (Uniklinik Köln (Colònia, Alemanya)) ;
Chakupurakal, Geothy (Uniklinik Köln (Colònia, Alemanya)) ;
Fiedler, Anne (Uniklinik Köln (Colònia, Alemanya)) ;
Schlösser, Hans A. (Department of General, Visceral and Cancer Surgery, University Hospital of Cologne) ;
Fischer, Rieke (Department I of Internal Medicine, University Hospital of Cologne) ;
Theurich, Sebastian (Max Planck Institute for Metabolism Research Cologne) ;
Shimabukuro-Vornhagen, Alexander (Uniklinik Köln (Colònia, Alemanya)) ;
von Bergwelt-Baildon, Michael (Uniklinik Köln (Colònia, Alemanya)) ;
Vall d'Hebron Institut de Recerca (VHIR) ;
Universitat Autònoma de Barcelona
The introduction of checkpoint inhibitors represents a major advance in cancer immunotherapy. Some studies on checkpoint inhibition demonstrate that combinatorial immunotherapies with secondary drivers of anti-tumor immunity provide beneficial effects for patients that do not show a strong endogenous immune response. [...]
2016 - 10.18632/oncotarget.7720
Oncotarget, Vol. 8 (february 2016) , p. 27740-27753
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Are microglial cells the regulators of lymphocyte responses in the CNS?
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Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The infiltration of immune cells in the central nervous system is a common hallmark in different neuroinflammatory conditions. Accumulating evidence indicates that resident glial cells can establish a cross-talk with infiltrated immune cells, including T-cells, regulating their recruitment, activation and function within the CNS. [...]
2015 - 10.3389/fncel.2015.00440
Frontiers in cellular neuroscience, Vol. 16 Núm. 9 (November 2015) , Article ID 440
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21 p, 2.1 MB |
Natural Polymorphisms in Tap2 Influence Negative Selection and CD4:CD8 Lineage Commitment in the Rat
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Tuncel, Jonatan (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Haag, Sabrina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Yau, Anthony C. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Norin, Ulrika (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Baud, Amelie (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Lönnblom, Erik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Maratou, Klio (Imperial College London) ;
Ytterberg, A. Jimmy (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ekman, Diana (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Thordardottir, Soley (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Johannesson, Martina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Gillett, Alan (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Stridh, Pernilla (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Jagodic, Maja (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Olsson, Tomas (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Zubarev, Roman (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Mott, Richard (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Aitman, Timothy J. (Imperial College London) ;
Flint, Jonathan (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Holmdahl, Rikard (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
EURATRANS Consortium
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. [...]
2014 - 10.1371/journal.pgen.1004151
PLoS Genetics, Vol. 10 Issue 2 (February 2014) , p. e1004151
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114 p, 1.5 MB |
Bioinformatic Study of Antigen Presentation by HLA class II
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Muñoz Torres, Pau Marc ;
Daura i Ribera, Xavier, dir. ;
Cedano Rodríguez, Juan Antonio, dir. ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Entendre quin és el cribratge al que estan sotmesos els pèptids abans de poder-se unir a les molècules del complex major d'histocompatibilitat classe II o major histocompatibility complex class II en angles (MHC classe II o HLA classe II en humans) per a més tard ser presentats als limfòcits T és especialment rellevant per les seves implicacions en salut, a l'estar involucrats en diferents processos relacionats amb la defensa de l'organisme, des de la resposta davant d'infeccions a les reaccions autoimmunitàries, passant pel reconeixement de les cèl·lules cancerígenes. [...]
Understanding how peptides are selectively bound and presented by major histocompatibility complex class II molecules (MHC class II or HLA class II in humans) is of outmost importance for its broad implications in human health, from infection to autoimmunity or cancer. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014
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