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1.
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16 p, 5.9 MB |
Adipokines as New Biomarkers of Immune Recovery : Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy
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Yeregui, Elena (Instituto de Salud Carlos III) ;
Masip, J. (Instituto de Salud Carlos III) ;
Viladés, C. (Instituto de Salud Carlos III) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Y.M. (Universidad de Sevilla) ;
Blanco, J. (Universitat de Vic - Universitat Central de Catalunya) ;
Mallolas Masferrer, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alba, Verónica (Instituto de Salud Carlos III) ;
Vargas, M. (Instituto de Salud Carlos III) ;
García-Pardo, G. (Instituto de Salud Carlos III) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Olona, M. (Instituto de Salud Carlos III) ;
Vidal-González, J. (Universitat de Barcelona) ;
Peraire, M. (Universitat Rovira i Virgili) ;
Martí, A. (Instituto de Salud Carlos III) ;
Reverté, L. (Instituto de Salud Carlos III) ;
Gómez-Bertomeu, F. (Instituto de Salud Carlos III) ;
Leal, M. (Hospital Viamed Santa Ángela de la Cruz) ;
Vidal, F. (Instituto de Salud Carlos III) ;
Peraire, J. (Instituto de Salud Carlos III) ;
Rull, A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. [...]
2022 -  10.3390/ijms23042202
International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202
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9 p, 419.0 KB |
Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe
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Hofstra, L.M. (University Medical Center Utrecht) ;
Sauvageot, N. ;
Albert, J. ;
Alexiev, I. ;
Garcia, F. ;
Struck, D. ;
Van De Vijver, D.A.M.C. ;
Åsjö, B. ;
Beshkov, D. ;
Coughlan, S. ;
Descamps, D. ;
Griskevicius, A. ;
Hamouda, O. ;
Horban, A. ;
Van Kasteren, M. ;
Kolupajeva, T. ;
Kostrikis, L.G. ;
Liitsola, K. ;
Linka, M. ;
Mor, O. ;
Nielsen, C. ;
Otelea, D. ;
Paraskevis, D. ;
Paredes, R. ;
Puchhammer-Stöckl, E. (Medical University Vienna) ;
Sönnerborg, A. ;
Staneková, D. (Slovak Medical University) ;
Stanojevic, M. (University of Belgrade) ;
Van Laethem, K. ;
Zazzi, M. ;
Lepej, S.Z. ;
Boucher, C.A.B. ;
Schmit, J.C. ;
Wensing, A.M.J. ;
Puchhammer-Stockl, E. ;
Sarcletti, M. ;
Schmied, B. ;
Geit, M. ;
Balluch, G. ;
Vandamme, A. M. ;
Vercauteren, J. ;
Derdelinckx, I. ;
Sasse, A. ;
Bogaert, M. ;
Ceunen, H. ;
De Roo, A. ;
De Wit, S. ;
Echahidi, F. ;
Fransen, K. ;
Goffard, J.C. ;
Goubau, P. ;
Goudeseune, E. ;
Yombi, J.C. ;
Lacor, P. ;
Liesnard, C. ;
Moutschen, M. ;
Pierard, D. ;
Rens, R. ;
Schrooten, Y. ;
Vaira, D. ;
Vandekerckhove, L.P.R. ;
Van Den Heuvel, A. ;
Van Der Gucht, B. ;
Van Ranst, M. ;
Van Wijngaerden, E. ;
Vandercam, B. ;
Vekemans, M. ;
Verhofstede, C. ;
Clumeck, N. ;
Begovac, J. ;
Demetriades, I. ;
Kousiappa, I. ;
Demetriou, V. ;
Hezka, J. ;
Maly, M. ;
Machala, L. ;
Jørgensen, L.B. ;
Gerstoft, J. ;
Mathiesen, L. ;
Pedersen, C. ;
Nielsen, H. ;
Laursen, A. ;
Kvinesdal, B. ;
Ristola, M. ;
Suni, J. ;
Sutinen, J. ;
Assoumou, L. ;
Castor, G. ;
Grude, M. ;
Flandre, P. ;
Storto, A. ;
Kücherer, C. ;
Berg, T. ;
Braun, P. ;
Poggensee, G. ;
Däumer, M. ;
Eberle, J. ;
Heiken, H. ;
Kaiser, R. ;
Knechten, H. ;
Korn, K. ;
Müller, H. ;
Neifer, S. ;
Schmidt, B. ;
Walter, H. ;
Gunsenheimer-Bartmeyer, B. ;
Harrer, T. ;
Hatzakis, A. ;
Zavitsanou, A. ;
Vassilakis, A. ;
Lazanas, M. ;
Chini, M. ;
Lioni, A. ;
Sakka, V. ;
Kourkounti, S. ;
Paparizos, V. ;
Antoniadou, A. ;
Papadopoulos, A. ;
Poulakou, G. ;
Katsarolis, I. ;
Protopapas, K. ;
Chryssos, G. ;
Drimis, S. ;
Gargalianos, P. ;
Xylomenos, G. ;
Lourida, G. ;
Psichogiou, M. ;
Daikos, G.L. ;
Sipsas, N.V. ;
Kontos, A. ;
Gamaletsou, M.N. ;
Koratzanis, G. ;
Sambatakou, E. ;
Mariolis, H. ;
Skoutelis, A. ;
Papastamopoulos, V. ;
Georgiou, O. ;
Panagopoulos, P. ;
Maltezos, E. ;
De Gascun, C. ;
Byrne, C. ;
Duffy, M. ;
Bergin, C. ;
Reidy, D. ;
Farrell, G. ;
Lambert, Jo ;
O'Connor, E. ;
Rochford, A. ;
Low, J. ;
Coakely, P. ;
O'Dea, S. ;
Hall, W. ;
Levi, I. ;
Chemtob, D. ;
Grossman, Z. ;
De Luca, A. ;
Balotta, C. ;
Riva, C. ;
Mussini, C. ;
Caramma, I. ;
Capetti, A. ;
Colombo, M.C. ;
Rossi, C. ;
Prati, F. ;
Tramuto, F. ;
Vitale, F. ;
Ciccozzi, M. ;
Angarano, G. ;
Rezza, G. ;
Vasins, O. ;
Lipnickiene, V. ;
Hemmer, R. ;
Arendt, V. ;
Michaux, C. ;
Staub, T. ;
Sequin-Devaux, C. ;
Van Kessel, A. ;
Van Bentum, P.H.M. ;
Brinkman, K. ;
Connell, B.J. ;
Van Der Ende, M.E. ;
Hoepelman, I.M. ;
Kuipers, M. ;
Langebeek, N. ;
Richter, C. ;
Santegoets, R.M.W.J. ;
Schrijnders-Gudde, L. ;
Schuurman, R. ;
Van De Ven, B.J.M. ;
Kran, A.M.B. ;
Ormaasen, V. ;
Aavitsland, P. ;
Stanczak, J.J. ;
Stanczak, G.P. ;
Firlag-Burkacka, E. ;
Wiercinska-Drapalo, A. ;
Jablonowska, E. ;
Maolepsza, E. ;
Leszczyszyn-Pynka, M. ;
Szata, W. ;
Camacho, R. ;
Palma, C. ;
Borges, F. ;
Paixão, T. ;
Duque, V. ;
Araújo, F. ;
Paraschiv, S. ;
Tudor, A.M. ;
Cernat, R. ;
Chiriac, C. ;
Dumitrescu, F. ;
Prisecariu, L.J. ;
Jevtovic, D. ;
Salemovic, D. ;
Stanekova, D. ;
Habekova, M. ;
Chabadová, Z. ;
Drobkova, T. ;
Bukovinova, P. ;
Shunnar, A. ;
Truska, P. ;
Lunar, M. ;
Babic, D. ;
Tomazic, J. ;
Vidmar, L. ;
Vovko, T. ;
Karner, P. ;
Monge, S. ;
Moreno, S. ;
Del Amo, J. ;
Asensi, V. ;
Sirvent, J.L. ;
De Mendoza, C. ;
Delgado, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Gutiérrez, F. ;
Berenguer, J. ;
Garcia-Bujalance, S. ;
Stella, N. ;
De Los Santos, I. ;
Blanco, J.R. ;
Dalmau, D. ;
Rivero, M. ;
Segura, F. ;
Elías, M.J.P. ;
Álvarez, Mar ;
Chueca, N. ;
Rodríguez-Martín, C. ;
Vidal, C. ;
Palomares, J.C. ;
Viciana, I. ;
Viciana, P. ;
Cordoba, J. ;
Aguilera, A. ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Galindo, M.J. ;
Miralles, C. ;
Del Pozo, M.A. ;
Ribera, E. ;
Iribarren, J.A. ;
Ruiz, L. ;
De La Torre, J. ;
Vidal, F. ;
Clotet Sala, Bonaventura ;
Heidarian, A. ;
Aperia-Peipke, K. ;
Axelsson, M. ;
Mild, M. ;
Karlsson, A. ;
Thalme, A. ;
Naver, Lars ;
Bratt, G. ;
Blaxhult, A. ;
Gisslén, M. ;
Svennerholm, B. ;
Björkman, P. ;
Säll, C. ;
Mellgren, None ;
Lindholm, A. ;
Kuylenstierna, N. ;
Montelius, R. ;
Azimi, F. ;
Johansson, B. ;
Carlsson, M. ;
Johansson, E. ;
Ljungberg, B. ;
Ekvall, H. ;
Strand, A. ;
Mäkitalo, S. ;
Öberg, S. ;
Holmblad, P. ;
Höfer, M. ;
Holmberg, H. ;
Josefson, P. ;
Ryding, U. ;
Bergbrant, I. ;
Universitat Autònoma de Barcelona
Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. [...]
2016 - 10.1093/cid/civ963
Clinical Infectious Diseases, Vol. 62 Núm. 5 (january 2016) , p. 655-663
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12 p, 3.0 MB |
Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation
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Masip, Jenifer (Hospital Universitari Joan XXIII de Tarragona) ;
Jorba, Rosa (Hospital Universitari Joan XXIII de Tarragona) ;
López Dupla, Jesús Miguel (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Yolanda María (Laboratorio de Inmunología. Instituto de Biomedicina de Sevilla. Hospital Universitario Virgen del Rocío. Consejo Superior de Investigaciones Científicas (Espanya). Universidad de Sevilla) ;
García-Pardo, Graciano (Hospital Universitari Joan XXIII de Tarragona) ;
Martínez, Esteban (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Viladés, Consuelo (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Veloso, Sergi (Hospital Universitari Joan XXIII de Tarragona) ;
Alba, Verónica (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Olona, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Vidal, Francesc (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Gómez-Bertomeu, Frederic (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Peraire, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Rull, Anna (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. [...]
2022 - 10.3390/ijms23158071
International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8071
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19 p, 1.7 MB |
Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain
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Castro-Granell, V. (Hospital Marina Baixa (La Vila Joiosa, Alacant)) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Jaén, Ángeles (Fundació Docència i Recerca Mútua Terrassa) ;
Cenoz, Santiago (ViiV Healthcare (Tres Cantos, Madrid)) ;
Galindo, María José (Hospital Clínic Universitari (València)) ;
Fuster-RuizdeApodaca, María José (Sociedad Española Interdisciplinaria del Sida) ;
Universitat Autònoma de Barcelona
Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). [...]
2021 - 10.1371/journal.pone.0260334
PloS one, Vol. 16 Núm. 11 (november 2021) , p. e0260334
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7 p, 214.7 KB |
Long-term effectiveness of unboosted atazanavir plus abacavir/lamivudine in subjects with virological suppression
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Llibre, Josep M. (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Cozzi-Lepri, Alessandro (University College London, UK) ;
Pedersen, Court (Odense University Hospital (Dinamarca)) ;
Ristola, Matti (Helsinki University Hospital (Finlàndia)) ;
Losso, Marcelo (Hospital General de Agudos JM Ramos Mejía, Buenos Aires, Argentina) ;
Mocroft, Amanda (University College London, UK) ;
Mitsura, Viktar (Gomel State Medical University, Belarus) ;
Falconer, Karolin (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Maltez, Fernando (Curry Cabral Hospital, Lisboa, Portugal) ;
Beniowski, Marek (Specialistic Hospital, Chorzów, Poland) ;
Vullo, Vincenzo (Policlinico Umberto 1, Rome, Italy) ;
Hassoun, Gamal (Rambam-Health Care Campus, Haifa, Israel) ;
Kuzovatova, Elena (Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology named after Academician I.N. Blokhina, Russia) ;
Szlavik, János (St László Hospital (Hongria)) ;
Kuznetsova, Anastasiia (Kharkov State Medical University, Ukraine) ;
Stellbrink, Hans-Jürgen (ICH Study Center, Hamburg, Germany) ;
Duvivier, Claudine (APHP-Hôpital Necker-Enfants Malades, Paris, France) ;
Edwards, Simon (Mortimer Market Centre, UK) ;
Laut, Kamilla (Centre for Health & University of Copenhagen, Denmark) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Effectiveness data of an unboosted atazanavir (ATV) with abacavir/lamivudine (ABC/3TC) switch strategy in clinical routine are scant. We evaluated treatment outcomes of ATV + ABC/3TC in pretreated subjects in the EuroSIDA cohort when started with undetectable plasma HIV-1 viral load (pVL), performing a time to loss of virological response (TLOVR <50 copies/mL) and a snapshot analysis at 48, 96, and 144 weeks. [...]
2016 - 10.1097/MD.0000000000005020
Medicine, Vol. 95, Num. 40 (october 2016)
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7 p, 819.3 KB |
Factors associated to neurocognitive impairment in older adults living with HIV
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Gutierrez-San-Juan, Júlia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Arrieta-Aldea, Itziar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arnau-Barrés, Isabel (Hospital del Mar (Barcelona, Catalunya)) ;
García-Escobar, Greta (Hospital del Mar (Barcelona, Catalunya)) ;
Lerma-Chippirraz, Elisabet (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-García, Paula (Hospital del Mar (Barcelona, Catalunya)) ;
Marcos, Agustin (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Blasco-Hernando, Fabiola (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gonzalez-Mena, Alicia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cañas-Ruano, Esperanza (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Knobel Freud, Hernando (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Güerri-Fernández, Robert (Universitat Autònoma de Barcelona. Departament de Medicina)
The HIV infection is a chronic disease that causes neurocognitive impairment (NI) and has been related with early development of frailty. We aimed to study the main risk factors for neurocognitive disorders and frailty in HIV older adults. [...]
2022 - 10.1186/s40001-022-00639-6
European Journal of Medical Research, Vol. 27 (february 2022)
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15 p, 910.6 KB |
Recreational Drug Use in People Living with HIV in Spain : Factors Associated with Drug Use and the Impact on Clinical Outcomes
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Castro, Vanessa (Hospital Marina Baixa (La Vila Joiosa, Alacant)) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Jaén, Ángeles (Universitat de Barcelona) ;
Casado, José Luis (Hospital Universitario Ramón y Cajal (Madrid)) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
Cenoz, Santiago (ViiV Healthcare) ;
Fuster-RuizdeApodaca, María José (Universidad Nacional de Educación a Distancia (Espanya))
We analysed the impact of recreational drug use (RDU) on different outcomes in people living with HIV (PLHIV). A multicentre retrospective cohort study was performed with two cohorts of PLHIV included: people using recreational drugs (PURD) vs. [...]
2021 - 10.1007/s10461-021-03271-3
AIDS and Behavior, Vol. 25 (may 2021) , p. 3883-3897
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12 p, 653.9 KB |
HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy
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Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santos, José Ramón (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Virological failure (VF) to boosted PIs with a high genetic barrier is not usually linked to the development of resistance-associated mutations in the protease gene. From a cohort of 520 HIV-infected subjects treated with lopinavir/ritonavir or darunavir/ritonavir monotherapy, we retrospectively identified nine patients with VF. [...]
2020 - 10.1093/jac/dkaa228
Journal of antimicrobial chemotherapy, Vol. 75 (june 2020) , p. 2535-2546
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