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11.
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14 p, 1.4 MB |
Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors
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Pasculli, Barbara (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratorio di Oncologia) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratorio di Oncologia) ;
Fontana, Andrea (Fondazione IRCCS Casa Sollievo Della Sofferenza) ;
Biagini, T. (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratory of Bioinformatics Unit) ;
Di Viesti, M. P. (Department of Medicine. Scuola Medica Salernitana," University of Salerno) ;
Rendina, M. (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratorio di Oncologia) ;
Valori, V. M. (Fondazione IRCCS Casa Sollievo Della Sofferenza. UO di Oncologia. San Giovanni Rotondo) ;
Morritti, M. (Fondazione IRCCS Casa Sollievo Della Sofferenza. UO di Oncologia. San Giovanni Rotondo) ;
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS. Biosciences Laboratory) ;
Ravaioli, S. (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS. Biosciences Laboratory) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo Della Sofferenza. UO di Oncologia. San Giovanni Rotondo) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo Della Sofferenza) ;
Murgo, R. (Fondazione IRCCS Casa Sollievo Della Sofferenza) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo Della Sofferenza) ;
Mazza, T. (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratory of Bioinformatics Unit) ;
Fazio, V. M. (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratorio di Oncologia) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo Della Sofferenza. Laboratorio di Oncologia) ;
Universitat Autònoma de Barcelona
miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high miR-155-5p levels are associated with unfavorable prognostic factors in two independent breast cancer cohorts (CSS cohort, n = 283; and TCGA-BRCA dataset, n = 1,095). [...]
2020 -  10.3389/fonc.2020.01415
Frontiers in Oncology, Vol. 10 (december 2020) , p. 1415
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12.
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19 p, 3.0 MB |
Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against damage
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Pelletier, Joffrey (Institut d'Investigació Biomèdica de Bellvitge) ;
Riaño-Canalias, Ferran (Institut d'Investigació Biomèdica de Bellvitge) ;
Almacellas, Eugènia (Institut d'Investigació Biomèdica de Bellvitge) ;
Mauvezin, Caroline (Institut d'Investigació Biomèdica de Bellvitge) ;
Samino, Sara (Universitat Rovira i Virgili) ;
Feu, Sonia (Universitat de Barcelona) ;
Menoyo, Sandra (Institut d'Investigació Biomèdica de Bellvitge) ;
Domostegui, Ana (Institut d'Investigació Biomèdica de Bellvitge) ;
Garcia-Cajide, Marta (Institut d'Investigació Biomèdica de Bellvitge) ;
Salazar, Ramon (Institut Català d'Oncologia) ;
Cortes Crignola, Constanza (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Tauler, Albert (Universitat de Barcelona) ;
Yanes, Oscar (Universitat Rovira i Virgili) ;
Agell, Neus (Universitat de Barcelona) ;
Kozma, Sara C. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gentilella, Antonio (Universitat de Barcelona) ;
Thomas, George (Universitat de Barcelona)
Many oncogenes enhance nucleotide usage to increase ribosome content, replication, and cell proliferation, but in parallel trigger p53 activation. Both the impaired ribosome biogenesis checkpoint () and the damage response () have been implicated in p53 activation following nucleotide depletion. [...]
2020 - 10.15252/embj.2019103838
EMBO Journal, Vol. 39 (june 2020)
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13.
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14 p, 6.4 MB |
ATR is required to complete meiotic recombination in mice
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Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rojas, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fuentes Lazaro, Judit (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas) ;
Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622
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14.
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11 p, 987.0 KB |
Activation of r20-dependent recombination and horizontal gene transfer in Mycoplasma genitalium
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Torres Puig, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Martínez Torró, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Granero Moya, Ignasi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pich, Òscar M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In the human pathogen Mycoplasma genitalium, homologous recombination is under the control of r, an alternative sigma factor that boosts the generation of genetic and antigenic diversity in the population. [...]
2018 - 10.1093/dnares/dsy011
DNA research, Vol. 25, issue 4 (2018) , p. 383-393
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15.
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24 p, 25.7 MB |
p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
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Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Castillo Ècija, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845
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16.
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13 p, 6.6 MB |
Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
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Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ;
Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ;
Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961
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17.
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27 p, 21.8 MB |
The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes
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Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017
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18.
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6 p, 700.6 KB |
IMKT : the integrative McDonald and Kreitman test
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Murga-Moreno, Jesus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coronado-Zamora, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Hervás Fernández, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The McDonald and Kreitman test (MKT) is one of the most powerful and widely used methods to detect and quantify recurrent natural selection using DNA sequence data. Here we present iMKT (acronym for integrative McDonald and Kreitman test), a novel web-based service performing four distinct MKT types. [...]
2019 - 10.1093/nar/gkz372
Nucleic acids research, Vol. 47, issue W1 (Jan. 2019) , p. W283-W288
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19.
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10 p, 3.0 MB |
CENP-A binding domains and recombination patterns in horse spermatocytes
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Cappelletti, Eleonora (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Piras, Francesca M. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Badiale, Claudia (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Bambi, Marina (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Santagostino, Marco (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Masterson, Teri A. (National University of Ireland. Centre for Chromosome Biology) ;
Sullivan, Kevin F. (National University of Ireland. Centre for Chromosome Biology) ;
Nergadze, Solomon G. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Giulotto, Elena (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani")
Centromeres exert an inhibitory effect on meiotic recombination, but the possible contribution of satellite DNA to this "centromere effect" is under debate. In the horse, satellite DNA is present at all centromeres with the exception of the one from chromosome 11. [...]
2019 - 10.1038/s41598-019-52153-1
Scientific reports, Vol. 9, issue 1 (Jan. 2019) , art. 15800
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20.
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12 p, 3.0 MB |
Mapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain
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Mouresan, Elena F (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal.) ;
González-Rodríguez, Aldemar (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal.) ;
Cañas Álvarez, Jhon Jacobo (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Munilla, S. (Universidad de Buenos Aires. Departamento de Producción Animal) ;
Altarriba, Juan (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal.) ;
Díaz, Clara (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Mejora Genética Animal) ;
Baró, J. A. (Instituto Agroalimentario de Aragón) ;
Molina, A. (Universidad de Valladolid. Departamento de Ciencias Agroforestales) ;
Lopez-Buesa, P. (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal.) ;
Piedrafita Arilla, Jesús (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Varona, L. (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal.)
In organisms with sexual reproduction, genetic diversity, and genome evolution are governed by meiotic recombination caused by crossing-over, which is known to vary within the genome. In this study, we propose a simple method to estimate the recombination rate that makes use of the persistency of linkage disequilibrium (LD) phase among closely related populations. [...]
2019 - 10.3389/fgene.2019.01170
Frontiers in genetics, Vol. 10 (20 2019) , p. 1170
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