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1.
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13 p, 1.8 MB |
Lymph Node Molecular Analysis with OSNA Enables the Identification of pT1 CRC Patients at Risk of Recurrence : A Multicentre Study
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Saez de Gordoa, Karmele (Hospital Clínic i Provincial de Barcelona) ;
Rodrigo-Calvo, Maria Teresa (Hospital Clínic i Provincial de Barcelona) ;
Archilla, Ivan (Hospital Clínic i Provincial de Barcelona) ;
Lopez-Prades, Sandra (Hospital Clínic i Provincial de Barcelona) ;
Díaz, Alba (Hospital Clínic i Provincial de Barcelona) ;
Tarragona, Jordi (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Machado, Isidro (Centro de Investigación Biomédica en Red en Cancer (CIBERONC)) ;
Ruiz Martín, Juan (Virgen de la Salud Hospital, Toledo) ;
Zaffalon, Diana (Consorci Sanitari de Terrassa) ;
Daca-Alvarez, Maria (Hospital Clínic i Provincial de Barcelona) ;
Pellisé, Maria (Hospital Clínic i Provincial de Barcelona) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona)
Early-stage colorectal carcinoma (CRC)-pT1-is a therapeutic challenge and presents some histological features related to lymph node metastasis (LNM). A significant proportion of pT1 CRCs are treated surgically, resulting in a non-negligible surgical-associated mortality rate of 1. [...]
2023 -  10.3390/cancers15225481
Cancers, Vol. 15 (november 2023)
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2.
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15 p, 603.6 KB |
Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer : A Multicenter Study
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Díaz-Feijoo, Berta (Hospital Clínic i Provincial de Barcelona) ;
Acosta, Úrsula (Vall d'Hebron Institut d'Oncologia) ;
Torne, Aureli (Hospital Clínic i Provincial de Barcelona) ;
Gil-Ibáñez, Blanca (Hospital 12 de Octubre (Madrid)) ;
Hernández Gutierrez, Alicia (Hospital Universitario La Paz (Madrid)) ;
Domingo, Santiago (Hospital Universitari i Politècnic La Fe (València)) ;
Bradbury, Melissa (Vall d'Hebron Institut d'Oncologia) ;
Gil-Moreno, Antonio 1965- (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC), which makes correct staging crucial. In contrast to existing studies evaluating pelvic lymphadenectomy after aortic lymphadenectomy, this study focuses on the pelvic node (PLN) debulking technique which has the dual objective of staging and cytoreduction. [...]
2022 - 10.3390/cancers14081974
Cancers, Vol. 14 (april 2022)
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3.
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17 p, 534.5 KB |
COAST : An Open-Label, Phase II, Multidrug Platform Study of Durvalumab Alone or in Combination with Oleclumab or Monalizumab in Patients with Unresectable, Stage III Non-Small-Cell Lung Cancer
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Herbst, Roy S. (Yale Cancer Center. Smilow Cancer Hospital) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Barlesi, Fabrice (Gustave Roussy) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Chu, Quincy (Cross Cancer Institute) ;
Monnet, Isabelle (Centre Hospitalier Intercommunal de Créteil) ;
Sánchez Hernández, Alfredo (Consorci Hospitalari Provincial de Castelló) ;
Dakhil, Shaker (Cancer Center of Kansas) ;
Camidge, D (University of Colorado Anschutz Medical Campus) ;
Winzer, Leanne (AstraZeneca) ;
Soo-Hoo, Yee (AstraZeneca) ;
Cooper, Zachary A. (AstraZeneca) ;
Kumar, Rakesh (AstraZeneca) ;
Bothos, John (AstraZeneca) ;
Aggarwal, Charu (Abramson Cancer Center. University of Pennsylvania) ;
Martinez-Marti, Alex (Vall d'Hebron Institut d'Oncologia)
PURPOSEDurvalumab significantly improves overall survival for patients with unresectable stage III non-small-cell lung cancer and no progression after concurrent chemoradiotherapy (cCRT). Building upon that standard of care, COAST is a phase II study of durvalumab alone or combined with the anti-CD73 monoclonal antibody oleclumab or anti-NKG2A monoclonal antibody monalizumab as consolidation therapy in this setting. [...]
2022 - 10.1200/JCO.22.00227
Journal of Clinical Oncology, Vol. 3 (january 2022) , p. JCO.22.00227
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4.
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15 p, 1.9 MB |
Cytology Smears : An Enhanced Alternative Method for Colorectal Cancer pN Stage-A Multicentre Study
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Diaz-Mercedes, Sherley (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Archilla, Ivan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lahoz, Sara (Hospital Clínic i Provincial de Barcelona) ;
Rodrigo-Calvo, Maria Teresa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lopez-Prades, Sandra (Hospital Clínic i Provincial de Barcelona) ;
Tarragona, Jordi (Hospital Arnau de Vilanova (València)) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Concha, Angel (Complejo Hospitalario Universitario de A Coruña) ;
Machado, Isidro (Hospital Quiron Salud) ;
Maurel, Joan (Universitat de Barcelona) ;
Chic, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Castells, Antoni (Universitat de Barcelona) ;
Balaguer, Francesc (Universitat de Barcelona) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cuatrecasas, Miriam (Universitat de Barcelona)
Recurrence of stage II (pT3-T4 pN0) colorectal cancer (CRC) occurs in about 15% of patients and it is often due to undetected lymph node (LN) metastases with conventional pathology haematoxylin and eosin (H&E) LN analysis. [...]
2022 - 10.3390/cancers14246072
Cancers, Vol. 14, Num. 24 (December 2022) , art. 6072
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5.
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11 p, 1.6 MB |
Tumour Cell Seeding to Lymph Nodes from In Situ Colorectal Cancer
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Rodrigo-Calvo, Maria Teresa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Saez de Gordoa, Karmele (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lopez-Prades, Sandra (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Archilla, Ivan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Díaz, Alba (Universitat de Barcelona) ;
Berrios, Mario (Hospital Universitario Central de Asturias) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Musulén, Eva (Institut Germans Trias i Pujol) ;
Cuatrecasas, Miriam (Universitat de Barcelona)
Lymph node (LN) metastasis is an important prognostic factor in colorectal cancer (CRC). We aimed to search for lymphatic vessels (LVs) in the lamina propria of 39 surgically resected in situ CRC, as well as to detect the presence of tumour burden in the regional LNs. [...]
2023 - 10.3390/cancers15030842
Cancers, Vol. 15, Num. 3 (January 2023) , art. 842
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6.
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10 p, 306.4 KB |
Patient-reported outcomes in relapsed/refractory multiple myeloma treated with melflufen plus dexamethasone : analyses from the Phase II HORIZON study
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Larocca, Alessandra (Azienda Ospedaliero - Universitaria Città della Salute e della Scienza) ;
Leleu, Xavier (CHU de Poitiers) ;
Touzeau, Cyrille (Université d'Angers) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Paner, Agne (Rush University Medical Center) ;
Mateos, M. V (Instituto de Investigación Biomédica de Salamanca) ;
Cavo, Michele (Bologna University School of Medicine) ;
Maisel, Christopher (Baylor Scott & White Charles A) ;
Alegre, Adrian (Hospital Universitario de la Princesa (Madrid)) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Raptis, Anastasios (niversity of Pittsburgh School of Medicine) ;
Rodriguez-Otero, Paula (Clínica Universidad de Navarra) ;
Mazumder, Amitabha (The Oncology Institute of Hope and Innovation) ;
Laubach, Jacob (Harvard Medical School) ;
Nadeem, Omar (Harvard Medical School) ;
Sandberg, Anna (Oncopeptides AB (Suècia)) ;
Orre, Marie (Oncopeptides AB (Suècia)) ;
Torrång, Anna (SDS Life Science (Suècia)) ;
Bakker, Nicolaas A (Oncopeptides AB) ;
Richardson, Paul G.. (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Relapsed/refractory multiple myeloma (RRMM) is known to have a high burden of disease and complications associated with refractoriness to prior lines of therapy. Severe pain and fatigue symptoms and impairments in physical and emotional functioning have been strongly linked to reduced health-related quality of life (HRQoL) in patients with RRMM. [...]
2022 - 10.1111/bjh.17887
British Journal of Haematology, Vol. 196 Núm. 3 (february 2022) , p. 639-648
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7.
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14 p, 3.9 MB |
Combined analysis of miR-200 family and its significance for breast cancer
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Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Dama, Elisa (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Rendina, Michelina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Morritti, Maria Grazia (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Melocchi, Valentina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Castelvetere, Marina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Valori, Vanna Maria (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Ravaioli, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Ciuffreda, Luigi (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Fazio, Vito Michele (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bianchi, Fabrizio (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza)
While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. [...]
2021 - 10.1038/s41598-021-82286-1
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 2980
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8.
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9 p, 1.6 MB |
Unsupervised machine learning improves risk stratification in newly diagnosed multiple myeloma : an analysis of the Spanish Myeloma Group
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Mosquera Orgueira, Adrian (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
González Pérez, Marta Sonia (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Diaz Arias, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Teruel, Ana Isabel (Hospital Clínic Universitari (València)) ;
Martínez-López, Joaquín (Hospital Universitario 12 de Octubre (Madrid)) ;
Palomera, Luis (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Granell, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Blanchard, María Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
de la Rubia, Javier (Hospital Universitari Doctor Peset (València)) ;
López de la Guia, Ana (Hospital Universitario La Paz (Madrid)) ;
Ríos-Tamayo, Rafael (Hospital Universitario Virgen de las Nieves (Granada)) ;
Sureda, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Hernández, Miguel Teodoro (Hospital Universitario de Canarias (La Laguna)) ;
Bengoechea, Enrique (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Calasanz, M.J (Clínica Universidad de Navarra) ;
Gutierrez, Norma (Hospital Universitario de Salamanca.) ;
Martin, María Luís (Hospital Universitario 12 de Octubre (Madrid)) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lahuerta, J. J (Hospital Universitario 12 de Octubre (Madrid)) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Mateos, M. V (Hospital Universitario de Salamanca) ;
Universitat Autònoma de Barcelona
2022 - 10.1038/s41408-022-00647-z
Blood Cancer Journal, Vol. 12 Núm. 4 (april 2022) , p. 76
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9.
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13 p, 822.1 KB |
SEOM clinical guideline for the management of cutaneous melanoma (2020)
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Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Manzano, J. L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marquez-Rodas, I. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Mujika, K. (Department of Medical Oncology. UGC de Oncología de Gipuzkoa. OSI Donostialdea-Onkologikoa) ;
Muñoz-Couselo, E. (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Ruiz, E. (Instituto de Investigación Biomédica de Málaga) ;
de la Cruz Merino, Luis (Universidad de Sevilla) ;
Espinosa, E. (Hospital Universitario La Paz (Madrid)) ;
Gonzalez-Cao, M. (Oncology Department (IOR). Hospital Dexeus) ;
Berrocal, A. (Department of Medical Oncology. Consorcio Hospital General Universitario de Valencia)
Melanoma affects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines to homogenize the management of these patients. [...]
2021 - 10.1007/s12094-020-02539-9
Clinical & Translational Oncology, Vol. 23 Núm. 5 (may 2021) , p. 948-960
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10.
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18 p, 4.0 MB |
Stages of Granulomatous Response Against Histozoic Metazoan Parasites in Mullets (Osteichthyes : Mugilidae)
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Polinas, Marta (University of Sassari. Department of Veterinary Medicine) ;
Padrós, Francesc 1965- (Universitat Autònoma de Barcelona. Servei de Diagnòstic Patològic en Peixos) ;
Merella, Paolo (University of Sassari. Department of Veterinary Medicine) ;
Prearo, Marino (State Veterinary Institute of Piedmont, Liguria and Aosta Valley. Fish Disease Laboratory) ;
Sanna, Marina Antonella (University of Sassari. Department of Veterinary Medicine) ;
Marino, Fabio (University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences) ;
Burrai, Giovanni Pietro (University of Sassari. Mediterranean Center for Disease Control) ;
Antuofermo, Elisabetta (University of Sassari. Mediterranean Center for Disease Control)
Parasitic diseases represent a common issue in fish and, when histozoic forms are present, this elicits a chronic inflammatory reaction leading to granuloma formation. Despite the large knowledge of granuloma formation due to parasites in visceral organs, little is known about the development and the evolutive stages of granulomas in naturally infected fish. [...]
2021 - 10.3390/ani11061501
Animals, Vol. 11 (may 2021)
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