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11.
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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 -  10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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12.
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14 p, 7.4 MB |
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
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Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ;
Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ;
Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ;
Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ;
Matsuba, Chikako (University of Southern California, Los Angeles, USA) ;
Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ;
Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ;
Unzueta, Fernando (Universitat de Barcelona) ;
Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ;
Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ;
Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ;
Cortés, Javier (Universidad Europea de Madrid) ;
DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lupien, Mathieu (University of Toronto) ;
Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - 10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)
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13.
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36 p, 4.7 MB |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
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García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ;
Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ;
Dietmann, Sabine (Washington University School of Medicine in St. Lou) ;
López, Judith (Instituto de Investigación Biomédica de Salamanca) ;
Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ;
D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ;
Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Paniagua, Alejandro (Universidad de Salamanca) ;
Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ;
Marchand, Virginie (Université de Lorraine, France) ;
Alonso-López, Diego (Universidad de Salamanca) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Tuñón, Ignacio (Universidad de Salamanca) ;
Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ;
Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ;
Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ;
Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ;
Sánchez-Martín, Manuel A. (Universidad de Salamanca) ;
De Las Rivas, Javier (Universidad de Salamanca) ;
Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Motorin, Yuri (Université de Lorrain) ;
Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ;
Pandolfi, Pier Paolo (University of Turin, Italy) ;
Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ;
Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 - 10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)
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14.
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9 p, 686.2 KB |
The relapsed acute lymphoblastic leukemia network (ReALLNet) : a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
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Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Bautista, Francisco (Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands) ;
Rubio, Alba (Hospital Infantil Universitario Niño Jesús) ;
Aguilar, Yurena (Hospital Miguel Servet Hospital) ;
Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Dapena, Jose L (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Pérez, Antonio (Universidad Autónoma de Madrid) ;
Ramirez, Manuel (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Saiz-Ladera, Cristina (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Izquierdo, Elisa (La Paz University Hospital) ;
Escudero, Adela (La Paz University Hospital) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Ortega, Margarita (Vall d'Hebron Institut d'Oncologia) ;
Hidalgo-Gómez, Gloria (Vall d'Hebron Institut d'Oncologia) ;
Palacio, Carlos (Vall d'Hebron Institut d'Oncologia) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Montero, Joan (Universitat de Barcelona) ;
Romecín, Paola A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zazo, Santiago (Universidad Politécnica de Madrid) ;
Alvarez, Federico (Universidad Politécnica de Madrid) ;
Parras, Juan (Universidad Politécnica de Madrid) ;
Ortega-Sabater, Carmen (University of Castilla-La Mancha) ;
Chulián, Salvador (Universidad de Cádiz) ;
Rosa, María (Universidad de Cádiz) ;
Cirillo, Davide (Barcelona Supercomputing Center) ;
García, Elena (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
García, Jorge (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Manzano-Muñoz, Albert (Universitat de Barcelona) ;
Minguela, Alfredo (Instituto Murciano de Investigación Biosanitaria) ;
Fuster, Jose L. (Instituto Murciano de Investigación Biosanitaria)
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. [...]
2023 - 10.3389/fped.2023.1269560
Frontiers in Pediatrics, Vol. 11 (september 2023)
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15.
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12 p, 945.0 KB |
Participatory action research intervention for improving sleep in inpatients with cancer
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Cabrera Jaime, Sandra (Institut d'Investigació Biomèdica de Bellvitge) ;
Martinez, Cristina (Institut d'Investigació Biomèdica de Bellvitge) ;
Gonzalo Bachiller, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zarza Arnau, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martin Maldonado, Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Belén Manrique Palles, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Artiga Sarrion, Inmaculada (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tierno Sanchez, Noelia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julià Torras, Joaquim (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sancho, Juan Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabrera Jaime, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aim: To design and implement a plan to improve oncohaematological patients' sleep. Background: The hospital environment can compromise inpatients' sleep, negatively impacting on health outcomes and patient satisfaction. [...]
2023 - 10.1111/jocn.16279
Journal of clinical nursing, Vol. 32 Núm. 7-8 (april 2023) , p. 1218-1229
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16.
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6 p, 870.5 KB |
Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy : differences according to KRAS G12C vs. non-G12C
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Notario, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cerdà, Gabriela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanz, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz-Mármol, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domènech, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Costa, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saigí, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. [...]
2023 - 10.3389/fonc.2023.1239000
Frontiers in Oncology, Vol. 13 (october 2023)
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17.
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8 p, 715.4 KB |
Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure
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Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò)) ;
Charvat, Hadrien (National Cancer Center (Japò)) ;
Chiang, Chung-Ju (Taiwan Cancer Registry Center) ;
Lee, Wen-Chung (Taiwan Cancer Registry Center) ;
van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ;
Mousavi, Mohsen (East Switzerland Cancer Registry) ;
Craig, Stefano (Queen's University Belfast) ;
Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal)) ;
Rubió-Casadevall, Jordi (Institut de Recerca Biomèdica de Lleida) ;
Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan) ;
Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan) ;
Resteghini, Carlo (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Trama, Annalisa (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. [...]
2023 - 10.3389/fonc.2023.1219111
Frontiers in Oncology, Vol. 13 (2023) , p. 1219111
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18.
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16 p, 2.6 MB |
uPA/uPAR and SERPINE1 in head and neck cancer : Role in tumor resistance, metastasis, prognosis and therapy
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Pavón, Miguel Angel (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Arroyo-Solera, Irene (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Céspedes, María Virtudes (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Casanova Rigat, Isolda (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
León i Vintró, Xavier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mangues, Ramon 1957- (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Universitat Autònoma de Barcelona
There is strong evidence supporting the role of the plasminogen activator system in head and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase plasminogen activator)/uPAR (urokinase plasminogen activator receptor) and SERPINE1 components. [...]
2016 - 10.18632/oncotarget.10344
Oncotarget, Vol. 7 Núm. 35 (2016) , p. 57351-57366
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19.
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9 p, 1.4 MB |
Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features
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Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domenech, Montserrat (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marqués, Miriam (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, Raquel (Centro Nacional de Investigaciones Oncológicas) ;
Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gago, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sant, Francesc (Althaia Xarxa Assistencial Universitària de Manresa) ;
Lopez, Hector (Althaia Xarxa Assistencial Universitària de Manresa) ;
Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Malats, Núria (Centro Nacional de Investigaciones Oncológicas) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Real, Francisco X. (Universitat Pompeu Fabra)
Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting the need for predictive biomarkers. [...]
2023 - 10.3389/fonc.2023.1155244
Frontiers in Oncology, Vol. 13 (august 2023)
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20.
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53 p, 9.1 MB |
Recent advances on smart glycoconjugate vaccines in infections and cancer
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Anderluh, Marko (Univerza V Ljubljani) ;
Berti, Francesco (Technical R&D, GSK Vaccines S.r.l., Siena, Italy) ;
Bzducha-Wróbel, Anna (Warsaw University of Life Sciences-SGGW, Warszawa, Poland) ;
Chiodo, Fabrizio (Vrije Universiteit Amsterdam, The Netherlands) ;
Colombo, Cinzia (University of Milan, Italy) ;
Compostella, Federica (University of Milan, Italy) ;
Durlik, Katarzyna (Jan Kochanowski University, Kielce, Poland) ;
Ferhati, Xhenti (University of Florence, Sesto Fiorentino, Italy) ;
Holmdahl, Rikard (Karolinska Institute, Stockholm, Sweden) ;
Jovanovic, Dragana (University of Belgrade, Serbia) ;
Kaca, Wieslaw (Jan Kochanowski University, Kielce, Poland) ;
Lay, Luigi (University of Milan, Italy) ;
Marinovic-Cincovic, Milena (University of Belgrade, Serbia) ;
Marradi, Marco (University of Florence, Italy) ;
Ozil, Musa (Recep Tayyip Erdogan University, Rize, Turkey) ;
Polito, Laura (National Research Council, CNR-SCITEC, Milan, Italy) ;
Reina, Jose Juan (Universidad de Malaga-IBIMA) ;
Reis, Celso A. (University of Porto, Portugal) ;
Sackstein, Robert (Florida International University, Miami, USA) ;
Silipo, Alba (Complesso Universitario Monte Sant'Angelo, Napoli, Italy) ;
Švajger, Urban (Blood Transfusion Center of Slovenia, Ljubljana, Slovenia) ;
Vaněk, Ondřej (Charles University, Prague, Czech Republic) ;
Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Richichi, Barbara (University of Florence, Italy) ;
van Vliet, Sandra J. (Vrije Universiteit Amsterdam, The Netherlands)
Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. [...]
2022 - 10.1111/febs.15909
FEBS Journal, Vol. 289 Núm. 14 (july 2022) , p. 4251-4303
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