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19 p, 1.4 MB |
Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro : Implications for age-related macular degeneration
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Romero-Vázquez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona) ;
Figueras-Roca, Marc (Hospital Clínic i Provincial de Barcelona) ;
Llorenç, Victor (Hospital Clínic i Provincial de Barcelona) ;
Slevin, M. (Manchester Metropolitan University) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Dick, Andrew D (University College London Institute of Ophthalmology) ;
Molins, Blanca (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
The retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. [...]
2020 -  10.18632/aging.103655
Aging (Albany NY), Vol. 12 Núm. 14 (31 2020) , p. 13905-13923
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13 p, 831.5 KB |
12-year evolution of multimorbidity patterns among older adults based on Hidden Markov Models
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Roso-Llorach, Albert (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Vetrano, Davide L. (Stockholm Gerontology Research Center) ;
Trevisan, Caterina (University of Ferrara) ;
Fernández, Sergio (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Guisado-Clavero, Marina (Servicio de Salud de Madrid) ;
Carrasco-Ribelles, Lucia Amalía (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Fratiglioni, Laura (Stockholm Gerontology Research Center) ;
Violán, Concepció (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Calderón-Larrañaga, Amaia (Stockholm Gerontology Research Center) ;
Universitat Autònoma de Barcelona
Background: The evolution of multimorbidity patterns during aging is still an under-researched area. We lack evidence concerning the time spent by older adults within one same multimorbidity pattern, and their transitional probability across different patterns when further chronic diseases arise. [...]
2022 - 10.18632/aging.204395
Aging (Albany NY), Vol. 14 (november 2022) , p. 9805-9817
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20 p, 938.1 KB |
Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease
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Castelblanco, Esmeralda (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Sarrias, Maria R. (Institut Germans Trias i Pujol) ;
Betriu, Àngels (Institut de Recerca Biomèdica de Lleida) ;
Barranco-Altirriba, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Franch-Nadal, Josep (Institut Català de la Salut) ;
Valdivielso, José Manuel (Institut de Recerca Biomèdica de Lleida) ;
Bermúdez-López, Marcelino (Institut de Recerca Biomèdica de Lleida) ;
Groop, Per-Henrik (Department of Diabetes. Central Clinical School. Monash University) ;
Fernández, Elvira (Institut de Recerca Biomèdica de Lleida) ;
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a predefined composite CV endpoint (unstable angina, myocardial infarction, transient ischemic attack, cerebrovascular accident, congestive heart failure, arrhythmia, peripheral arterial disease [PAD] or amputation by PAD, aortic aneurysm, or death from CV causes) and all-cause mortality using Cox proportional hazards regression, adjusted for CV risk factors. [...]
2021 - 10.18632/aging.203615
Aging (Albany NY), Vol. 13 Núm. 19 (15 2021) , p. 22690-22709
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43 p, 4.0 MB |
Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system
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Gras, Sílvia (Universitat de Lleida. Departament de Medicina Experimental) ;
Blasco, Alba (Universitat de Lleida. Departament de Medicina Experimental) ;
Mòdol-Caballero, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tarabal, Olga (Universitat de Lleida. Departament de Medicina Experimental) ;
Casanovas, Anna (Universitat de Lleida. Departament de Medicina Experimental) ;
Piedrafita, Lídia (Universitat de Lleida. Departament de Medicina Experimental) ;
Barranco, Alejandro (Universidad de Granada. Departamento de Bioquímica y Biología Molecular) ;
Das, Tapas (Abbott Nutrition, Research and Development, Columbus, OH 43215, USA) ;
Rueda, Ricardo (Abbott Nutrition, Research and Development, Granada, Spain) ;
Pereira, Suzette L. (Abbott Nutrition, Research and Development, Columbus, OH 43215, USA) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Esquerda, Josep E. (Universitat de Lleida. Departament de Medicina Experimental) ;
Calderó, Jordi (Universitat de Lleida. Departament de Medicina Experimental)
Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, noticeable microgliosis has also been observed around aged MNs. [...]
2021 - 10.18632/aging.203336
Aging (Albany NY), Vol. 13 Num. 14 (july 2021) , p. 18051-18093
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26 p, 2.8 MB |
Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1
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Martínez-Gutiérrez, Alfredo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Duran, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marazuela Duque, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Simonet, Nicolas G.. (Institut d'Investigació Biomèdica de Bellvitge) ;
Yousef, Ibraheem (ALBA Laboratori de Llum de Sincrotró) ;
Martínez-Rovira, Immaculada (Universitat Autònoma de Barcelona. Departament de Física) ;
Martínez-Hoyos, Josefina (Mesostetic Pharma Group) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge)
UV radiation is one of the main contributors to skin photoaging by promoting the accumulation of cellular senescence, which in turn induces a proinflammatory and tissue-degrading state that favors skin aging. [...]
2021 - 10.18632/aging.203010
Aging (Albany NY), Vol. 13, Issue 9 (April 2021) , p. 12308-12333
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22 p, 2.3 MB |
Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection
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Anglada Pons, Teresa (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. [...]
2020 - 10.18632/aging.202419
Aging (Albany NY), Vol. 12, Issue 24 (December 2020) , p. 24872-24893
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21 p, 2.7 MB |
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
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Chen, C. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Wei, Y. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University) ;
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Lin, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
You, D. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Lai, L. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Shen, S. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University) ;
Su, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Shafer, A. (Harvard Medical School) ;
Fleischer, T. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Wang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Helland, Å. (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zhang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Chen, F. (Jiangsu Key Lab of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. [...]
2020 - 10.18632/aging.103284
Aging (Albany NY), Vol. 12 Núm. 11 (15 2020) , p. 10642-10662
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