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9 p, 634.4 KB |
Cortical atrophy and amyloid and tau deposition in Down syndrome : A longitudinal study
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Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Walpert, Madeleine J. (University of Cambridge. Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry) ;
Hong, Young T. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ;
Fryer, Tim D. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ;
Coles, Jonathan (University of Cambridge. Division of Anaesthesia. Department of Medicine) ;
Aigbirhio, Franklin I. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ;
Hartley, Sigan L. (University of Wisconsin-Madison. Waisman Center) ;
Cohen, Ann (University of Pittsburgh. Department of Psychiatry) ;
Tudorascu, Dana L. (University of Pittsburgh. Department of Psychiatry) ;
Christian, Bradley T. (University of Wisconsin-Madison. Waisman Center) ;
Handen, Benjamin L. (University of Pittsburgh. Department of Psychiatry) ;
Klunk, William E. (University of Pittsburgh. Department of Psychiatry) ;
Holland, Anthony John (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital) ;
Zaman, Shahid H. (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital)
Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). [...]
2022 -  10.1002/dad2.12288
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 14 Núm. 1 (2022) , p. e12288
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10 p, 497.8 KB |
The AT(N) framework for Alzheimer's disease in adults with Down syndrome
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Rafii, Michael S. (University of Southern California) ;
Ances, Beau M. (Washington University School of Medicine in St. Louis) ;
Schupf, Nicole (Columbia University Medical Center) ;
Krinsky-McHale, Sharon J. (NYS Institute for Basic Research in Developmental Disabilities) ;
Mapstone, Mark (University of California) ;
Silverman, Wayne (University of California) ;
Lott, Ira (University of California) ;
Klunk, Willian (University of Pittsburgh) ;
Head, Elizabeth (University of California) ;
Christian, Brad (University of Wisconsin Madison) ;
Lai, Florence (Massachusetts General Hospital) ;
Rosas, H.Diana (Harvard Medical School) ;
Zaman, Shahid (Cambridgeshire and Peterborough NHS Foundation Trust) ;
Petersen, Melissa E. (University of North Texas Health Science Center) ;
Strydom, Andre (King's College London) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin (University of Pittsburgh) ;
O'Bryant, Sid (University of North Texas Health Science Center) ;
Universitat Autònoma de Barcelona
The National Institute on Aging in conjunction with the Alzheimer's Association (NIA-AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (amyloid, tau, neurodegeneration, AT[N]) instead of clinical symptoms and represents the latest understanding that the pathological processes underlying AD begin decades before the manifestation of symptoms. [...]
2020 - 10.1002/dad2.12062
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 Núm. 1 (2020) , p. e12062
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10 p, 1.7 MB |
Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests
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Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez, S. (Fundació Catalana Síndrome de Down) ;
Giménez, Sandra (Institut d'Investigació Biomèdica Sant Pau) ;
Iulita, Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Garzón, Diana (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Bartrés-Faz, David (Universitat de Barcelona) ;
Videla, S. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population-based cohort of adults with Down syndrome (DS). Cross-sectional study. [...]
2020 - 10.1002/dad2.12047
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 Núm. 1 (2020) , p. e12047
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10 p, 344.1 KB |
Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease
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Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ;
Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ;
Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ;
Head, E. (Department of Pathology & Laboratory Medicine. University of California) ;
Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ;
Rebillat, A.S. (Jerome Lejeune Institute) ;
Sacco, S. (Jerome Lejeune Institute) ;
Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ;
Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ;
Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184
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Theoretical frameworks and approaches used within the Reserve, Resilience and Protective Factors professional interest area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment
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Bartrés-Faz, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arenaza-Urquijo, Eider (Pasqual Maragall Foundation) ;
Ewers, Michael (LMU Munich. University Hospital) ;
Belleville, Sylvie (Université de Montréal) ;
Chételat, G. (Normandie University) ;
Franzmeier, Nicolai (LMU Munich. University Hospital) ;
Gonneaud, Julie (McGill University) ;
de Echevarri, José María González (Pasqual Maragall Foundation) ;
Okonkwo, Ozioma (University of Wisconsin-Madison) ;
Schultz, Stephanie (University of Wisconsin-Madison) ;
Valenzuela, Michael (University of New South Wales) ;
Stern, Yaakov (Columbia University) ;
Vemuri, Prashanthi (Mayo Clinic Rochester Minnesota)
Reserve, resilience, maintenance, and related concepts are intensely debated in aging and Alzheimer's disease research. Through a short survey, we gathered information about theoretical concepts and methodologies used among research groups of the Reserve, Resilience, and Protective Factors Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment. [...]
2020 - 10.1002/dad2.12115
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 (november 2020)
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9 p, 2.2 MB |
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
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Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Pané, Adriana (Hospital Clínic i Provincial de Barcelona) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Ibarzabal, Ainitze (Hospital Clínic i Provincial de Barcelona) ;
Casajoana, Anna (Hospital Universitari de Bellvitge) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
de Hollanda, Ana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Vidal, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ortega, Emilio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Osorio, Ricardo (New York University School of Medicine) ;
Convit, Antonio (New York University School of Medicine) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Jiménez, Amanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. [...]
2020 - 10.1002/dad2.12052
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 (july 2020)
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12 p, 2.1 MB |
Challenges associated with biomarker-based classification systems for Alzheimer's disease
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Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Dickerson, Bradford C. (Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de Leon, Mony J.. (Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY, USA) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We aimed to evaluate the consistency of the A/T/N classification system. We included healthy controls, mild cognitive impairment, and dementia patients from Alzheimer's disease Neuroimaging Initiative. [...]
2018 - 10.1016/j.dadm.2018.03.004
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 10 (april 2018) , p. 346-357
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Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease
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Dekker, Alain D. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Vermeiren, Yannick (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Carmona Iragui, María (Fundació Catalana Síndrome de Down) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Videla Toro, Laura (Fundació Catalana Síndrome de Down) ;
Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Aerts, Tony (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Van Dam, Debby (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Fernández, Susana (Fundació Catalana Síndrome de Down) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Videla, Sebastian (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Sieben, Anne (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Martin, Jean-Jacques (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
De Deyn, Peter Paul (University Hospital Antwerp (Bèlgica)) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. [...]
2017 - 10.1016/j.dadm.2017.11.001
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 10 (november 2017) , p. 99-111
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Consensus guidelines for lumbar puncture in patients with neurological diseases
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Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Niemantsverdriet, Ellis (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ;
Struyfs, Hanne (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden) ;
Brouns, Raf (Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Dujmovic, Irena (Clinic of Neurology, Clinical Centre of Serbia, Department of Neurology, Faculty of Medicine, University of Belgrade School of Medicine, Belgrade, Serbia) ;
van der Flier, Wiesje (Amsterdam UMC. University Medical Center) ;
Frölich, Lutz (Central Institute of Mental Health (Manheim, Alemanya)) ;
Galimberti, Daniela (Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Hemmer, Bernhard (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Hoff, Erik (Department of Neurology, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands) ;
Hort, Jakub (International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic) ;
Iacobaeus, Ellen (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ingelsson, Martin (Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden) ;
Jan de Jong, Frank (Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands) ;
Jonsson, Michael (Sahlgrenska University Hospital (Suècia)) ;
Khalil, Michael (Department of Neurology, Medical University Graz, Graz, Austria) ;
Kuhle, Jens (University Hospital Basel (Basilea, Suïssa)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
de Mendonça, Alexandre (Laboratory of Neurosciences, Department of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Nagels, Guy (National MS Center Melsbroek, Brussels, Belgium) ;
Paquet, Claire (Research Memory Center Lariboisière Hospital University Paris Diderot INSERMU942, Paris, France) ;
Parnetti, Lucilla (Section of Neurology, Centre for Memory Disturbances, Department of Medicine, University of Perugia, Perugia, Italy) ;
Roks, Gerwin (Department of Neurology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands) ;
Rosa-Neto, Pedro (Departments of Psychiatry, McGill Centre for Studies in Aging, Douglas Hospital Research Center, McGill University, Montreal, Canada) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Skårsgard, Constance (Department of Geriatrics, Kalmar County Hospital, Kalmar, Sweden) ;
Stomrud, Erik (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ;
Tumani, Hayrettin (CSF Laboratory and Multiple Sclerosis Outpatient Unit, Department of Neurology, University of Ulm, Ulm, Germany) ;
Visser, Pieter Jelle (Maastricht University. Department of Psychiatry and Neuropsychology) ;
Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). Department of Molecular Neuroscience) ;
Duits, Flora (Amsterdam UMC. University Medical Center) ;
Teunissen, Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. [...]
2017 - 10.1016/j.dadm.2017.04.007
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 8 (may 2017) , p. 111-126
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