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12 p, 901.7 KB |
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
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Herraiz-Martínez, Adela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Llach, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Tarifa, Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gandía, Jorge (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Jiménez-Sábado, Verónica (Institut d'Investigació Biomèdica Sant Pau) ;
Lozano-Velasco, E. (Universidad de Jaén) ;
Serra, Selma A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vallmitjana, A. (Universitat Politècnica de Catalunya) ;
Vázquez Ruiz De Castroviejo, E. (Regional Hospital Ciudad de Jaén) ;
Benítez, R. (Universitat Politècnica de Catalunya) ;
Aránega, Amelia E (Universidad de Jaén) ;
Muñoz-Guijosa, C. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Franco, D. (Universidad de Jaén) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Hove-Madsen, Leif (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers their clinical utility. [...]
2019 -  10.1093/cvr/cvy215
Cardiovascular research, Vol. 115 Núm. 3 (january 2019) , p. 578-589
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0 p, 3.6 MB |
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
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Rohde, David (Massachusetts General Hospital and Harvard Medical School) ;
Vandoorne, Katrien (Massachusetts General Hospital and Harvard Medical School) ;
Lee, I-Hsiu (Department of Radiology, Massachusetts General Hospital) ;
Grune, Jana (Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ;
Zhang, Shuang (Department of Radiology, Massachusetts General Hospital) ;
McAlpine, Cameron S. (Department of Radiology, Massachusetts General Hospital) ;
Schloss, Maximilian J. (Department of Radiology, Massachusetts General Hospital) ;
Nayar, Ribhu (Department of Radiology, Massachusetts General Hospital) ;
Courties, Gabriel (Department of Radiology, Massachusetts General Hospital) ;
Frodermann, Vanessa (Department of Radiology, Massachusetts General Hospital) ;
Wojtkiewicz, Gregory (Massachusetts General Hospital) ;
Honold, Lisa (Department of Radiology, Massachusetts General Hospital) ;
Chen, Qi (Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ;
Schmidt, Stephen (Massachusetts General Hospital) ;
Iwamoto, Yoshiko (Massachusetts General Hospital) ;
Sun, Yuan (Department of Radiology, Massachusetts General Hospital) ;
Cremer, Sebastian (Department of Radiology, Massachusetts General Hospital) ;
Hoyer, Friedrich F. (Department of Radiology, Massachusetts General Hospital) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol) ;
Ji, Fei (Department of Molecular Biology, Massachusetts General Hospital) ;
Zhou, Bin (Chinese Academy of Sciences) ;
Adams, Ralf H. (Max Planck Institute for Molecular Biomedicine (Alemanya)) ;
Wythe, Joshua D. (Department of Molecular Physiology and Biophysics, Baylor College of Medicine (Estats Units d'Amèrica)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Watanabe, Hideto (Aichi Medical University) ;
Jung, Yookyung (Massachusetts General Hospital) ;
van der Laan, Anja M. (Department of Cardiology, University of Amsterdam) ;
Piek, Jan J. (Department of Cardiology, University of Amsterdam) ;
Kfoury, Youmna (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Désogère, Pauline A. (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Vinegoni, Claudio (Department of Radiology, Massachusetts General Hospital) ;
Dutta, Partha (Department of Medicine, University of Pittsburgh School of Medicine) ;
Sadreyev, Ruslan I. (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Caravan, Peter (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Libby, Peter (Department of Medicine, Brigham and Women's Hospital) ;
Scadden, David T. (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Lin, Charles P. (Aichi Medical University) ;
Naxerova, Kamila (Department of Radiology, Massachusetts General Hospital) ;
Swirski, Filip K. (Department of Radiology, Massachusetts General Hospital) ;
Nahrendorf, Matthias (Department of Internal Medicine I, University Hospital Wuerzburg)
Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ's microvasculature is unknown. [...]
2021 - 10.1038/s44161-021-00002-8
Nature cardiovascular research, Vol. 1 (december 2021) , p. 28-44
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3.
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14 p, 1.2 MB |
Progress in cardiac research : From rebooting cardiac regeneration to a complete cell atlas of the heart
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Davidson, Sean M (Hatter Cardiovascular Institute. University College London) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Bollini, S. (Department of Experimental Medicine (DIMES). University of Genova) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Duncker, D.J. (Division of Experimental Cardiology. Department of Cardiology. Erasmus University Medical Center) ;
Evans, P.C. (Department of Infection. Immunity and Cardiovascular Disease and Insigneo Institute. University of Sheffield) ;
Guzik, T. (Department of Medicine. Jagiellonian University. Collegium Medicum) ;
Hoefer, I.E. (Central Diagnostic Laboratory. University Medical Center Utrecht) ;
Waltenberger, J. (Department of Cardiovascular Medicine. Medical Faculty. University of Muenster) ;
Wojta, J. (Department of Internal Medicine Ii. Medical University of Vienna) ;
Weber, C. (Cardiovascular Research Institute Maastricht (CARIM). Department of Biochemistry. Maastricht University)
We review some of the important discoveries and advances made in basic and translational cardiac research in 2020. For example, in the field of myocardial infarction (MI), new aspects of autophagy and the importance of eosinophils were described. [...]
2021 - 10.1093/cvr/cvab200
Cardiovascular research, Vol. 117 Núm. 10 (january 2021) , p. 2161-2174
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13 p, 1.0 MB |
Organ-on-a-chip technology : A novel approach to investigate cardiovascular diseases
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Paloschi, V. (German Center for Cardiovascular Research (DZHK). Partner Site Munich Heart Alliance) ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Middelkamp, H. (BIOS/Lab on A Chip. University of Twente) ;
Vivas, Aisen (Applied Stem Cell Technologies. University of Twente) ;
Johansson, S.. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University) ;
Van Der Meer, A. (Applied Stem Cell Technologies. University of Twente) ;
Tenje, M. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University) ;
Maegdefessel, L. (Karolinska Institutet (Estocolm, Suècia). Department of Medicine)
The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. [...]
2021 - 10.1093/cvr/cvab088
Cardiovascular research, Vol. 117 Núm. 14 (january 2021) , p. 2742-2754
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13 p, 1.7 MB |
Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation
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Herraiz-Martínez, Adela (Institut d'Investigació Biomèdica Sant Pau) ;
Tarifa, Carmen (Institut d'Investigació Biomèdica Sant Pau) ;
Jiménez-Sábado, Verónica (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Llach, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Godoy-Marín, Hector (Universitat de Barcelona) ;
Colino-Lage, Hildegard (Institut d'Investigació Biomèdica Sant Pau) ;
Nolla-Colomer, Carme (Universitat Politècnica de Catalunya) ;
Casabella Ramón, Sergi (Institut d'Investigació Biomèdica Sant Pau) ;
Izquierdo-Castro, Paloma (Institut d'Investigació Biomèdica Sant Pau) ;
Benitez, Ivan David (Institut de Recerca Biomèdica de Lleida) ;
Benítez, Raúl (Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial) ;
Roselló-Díez, Elena (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez-Font, Enrique (Institut d'Investigació Biomèdica Sant Pau) ;
Viñolas, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Ciruela, Francisco (Universitat de Barcelona) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Hove-Madsen, Leif (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Atrial fibrillation (AF) has been associated with intracellular calcium disturbances in human atrial myocytes, but little is known about the potential influence of sex and we here aimed to address this issue. [...]
2021 - 10.1093/cvr/cvab127
Cardiovascular research, Vol. 118 (march 2021) , p. 1033-1045
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50 p, 1.3 MB |
CARDIOVASCULAR RNA MARKERS AND ARTIFICIAL INTELLIGENCE MAY IMPROVE COVID-19 OUTCOME : POSITION PAPER FROM THE EU-CardioRNA COST Action CA17129
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Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Robinson, Emma L. (Maastricht University) ;
Jusic, Amela (Cardiovascular Research Unit) ;
Carpusca, Irina (Cardiovascular Research Unit) ;
de Windt, Leon J.. (Department of Molecular Genetics) ;
Emanueli, Costanza (National Heart & Lung Institute) ;
Ferdinandy, Péter (Cardiometabolic Research Group and MTA-SE System Pharmacology Research Group) ;
Gu, Wei (Luxembourg Center for Systems Biomedicine) ;
Gyöngyösi, Mariann (Department of Cardiology) ;
Hackl, Matthias (TAmiRNA GmbH) ;
Karaduzovic-Hadziabdic, Kanita (Faculty of Engineering and Natural Sciences) ;
Lustrek, Mitja (Department of Intelligent Systems) ;
Martelli, Fabio (Molecular Cardiology Laboratory) ;
Nham, Eric (University of Zagreb School of Medicine) ;
Potočnjak, Ines (Institute for Clinical Medical Research and Education) ;
Satagopam, Venkata (Luxembourg Center for Systems Biomedicine) ;
Schneider, Reinhard (Luxembourg Center for Systems Biomedicine) ;
Thum, Thomas (Institute of Molecular and Translational Therapeutic Strategies (IMTTS)) ;
Devaux, Yvan (Cardiovascular Research Unit) ;
Universitat Autònoma de Barcelona
The coronavirus disease 2019 (COVID-19) pandemic has been as unprecedented as unexpected, affecting more than 105 million people worldwide as of February 8th, 2020 and causing more than 2. 3 million deaths according the World Health Organization. [...]
2021 - 10.1093/cvr/cvab094
Cardiovascular research, april 2021
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12 p, 1.1 MB |
High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model
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Ben-Aicha Gonzalez, Soumaya (Institut d'Investigació Biomèdica Sant Pau) ;
Escate, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Casaní, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Mendieta, Guiomar (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Universitat Autònoma de Barcelona. Càtedra de Recerca Cardiovascular) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
High-density lipoproteins (HDLs) are circulating micelles that transport proteins, lipids, and miRNAs. HDL-transported miRNAs (HDL-miRNAs) have lately received attention but their effects on vascular cells are not fully understood. [...]
2019 - 10.1093/cvr/cvz239
Cardiovascular research, Vol. 116 (august 2019) , p. 1288-1299
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11 p, 657.4 KB |
Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes
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Herraiz-Martínez, Adela (Institut d'Investigació Biomèdica Sant Pau) ;
Alvarez-Garcia, Jesus (Institut d'Investigació Biomèdica Sant Pau) ;
Llach, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Molina, Cristina E. (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandes, Jacqueline (Institut d'Investigació Biomèdica Sant Pau) ;
Ferrero-Gregori, Andreu (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Vallmitjana, Alexander (Universitat Politècnica de Catalunya) ;
Benítez, Raúl (Universitat Politècnica de Catalunya) ;
Padró Fernández, José María (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Hove-Madsen, Leif (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium handling in the human heart is sparse. [...]
2015 - 10.1093/cvr/cvv046
Cardiovascular research, Vol. 106 (february 2015) , p. 76-86
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13 p, 340.4 KB |
ESC working group cellular biology of the heart : position paper: improving the preclinical assessment of novel cardioprotective therapies
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Lecour, Sandrine (Hatter Institute for Cardiovascular Research (Àfrica)) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Condorelli, Gianluigi (Instituto Clinico Humanitas (Milano, Itàlia)) ;
Davidson, Sean M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
García-Dorado, David (Universitat Autònoma de Barcelona) ;
Engel, Felix B. (Friedrich-Alexander-Universität Erlangen-Nürnberg) ;
Ferdinandy, Péter (Semmelweis Egyetem. Department of Pharmacology and Pharmacotherapy) ;
Heusch, Gerd (Universitätsklinikum Essen) ;
Madonna, Rosalinda (Università degli Studi "G. d'Annunzio" Chieti) ;
Ovize, Michel (Université Claude Bernard Lyon 1) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Schulz, Rainer (Justus Liebig-Universität Gießen) ;
Sluijter, Joost P. G. (Universitair Medisch Centrum Utrecht) ;
Van Laake, Linda W. (Universitair Medisch Centrum Utrecht) ;
Yellon, Derek M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
Hausenloy, Derek J. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit))
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. [...]
2014 - 10.1093/cvr/cvu225
Cardiovascular research, Vol. 104, issue 3 (Dec. 2014) , p. 399-411
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