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10 p, 859.5 KB |
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks
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Zhang, Y. (University of Oxford) ;
Ghose, U. (University of Oxford) ;
Buckley, N.J. (University of Oxford) ;
Engelborghs, S. (Vrije Universiteit Brussel) ;
Sleegers, K. (University of Antwerp) ;
Frisoni, G.B. (Department of Psychiatry. University of Geneva) ;
Wallin, A. (University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (University of Zürich) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Legido-Quigley, C. (Steno Diabetes Center) ;
Barkhof, F. (University College London) ;
Zetterberg, H. (Kong Kong Center for Neurodegenerative Diseases) ;
Visser, P.J. (VU University Medical Center) ;
Bertram, L. (University of Oslo) ;
Lovestone, S. (Janssen RD) ;
Nevado-Holgado, A.J. (University of Oxford) ;
Shi, L. (University of Oxford) ;
Universitat Autònoma de Barcelona
Background and objective: Blood-based biomarkers represent a promising approach to help identify early Alzheimer's disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential biomarkers, but the most modern ML methods based on deep learning has however been scarcely explored. [...]
2022 -  10.3389/fnagi.2022.1040001
Frontiers in aging neuroscience, Vol. 14 (29 2022) , p. 1040001
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2.
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11 p, 1.1 MB |
Atrophy in the thalamus but not cerebellum is specific for C9orf72 FTD and ALS patients - An atlas-based volumetric MRI study
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Schönecker, Sonja (Ludwig-Maximilians-Universität) ;
Neuhofer, Christiane (Ludwig-Maximilians-Universität) ;
Otto, Markus (University of Ulm) ;
Ludolph, Albert (University of Ulm) ;
Kassubek, Jan (University of Ulm) ;
Landwehrmeyer, Bernhard (University of Ulm) ;
Anderl-Straub, Sarah (University of Ulm) ;
Semler, Elisa (University of Ulm) ;
Diehl-Schmid, Janine (Technical University of Munich) ;
Prix, Catharina (Ludwig-Maximilians-Universität) ;
Vollmar, Christian (Ludwig-Maximilians-Universität) ;
Fortea, Juan (Institut d'Investigació Sant Pau) ;
Huppertz, Hans-Jürgen (Swiss Epilepsy Clinic) ;
Arzberger, Thomas (Ludwig-Maximilians-Universität) ;
Edbauer, Dieter (Munich Cluster for Systems Neurology (SyNergy)) ;
Feddersen, Berend (Ludwig-Maximilians-Universität) ;
Dieterich, Marianne (Munich Cluster for Systems Neurology (SyNergy)) ;
Schroeter, Matthias L. (University Hospital Leipzig) ;
Volk, Alexander E. (University Medical Center Hamburg-Eppendorf) ;
Fließbach, Klaus (University Hospital Bonn (Bonn, Alemanya)) ;
Schneider, Anja (University Hospital Bonn (Bonn, Alemanya)) ;
Kornhuber, Johannes (Friedrich-Alexander University Erlangen-Nürnberg) ;
Maler, Manuel (Friedrich-Alexander University Erlangen-Nürnberg) ;
Prudlo, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Jahn, Holger (AMEOS Klinikum Heiligenhafen) ;
Boeckh-Behrens, Tobias (Technical University of Munich) ;
Danek, Adrian (Ludwig-Maximilians-Universität) ;
Klopstock, Thomas (Ludwig-Maximilians-Universität) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Universitat Autònoma de Barcelona
The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. [...]
2018 - 10.3389/fnagi.2018.00045
Frontiers in aging neuroscience, Vol. 10 Núm. FEB (15 2018) , p. 45
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3.
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11 p, 814.5 KB |
Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals : Examining the Necessity to Adjust for Biomarker Status in Normative Data
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Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Maastricht University) ;
Jansen, Willemijn J. (Maastricht University) ;
Vandenberghe, Rik (KU Leuven) ;
Gabel, Silvy (KU Leuven) ;
Estanga, Ainara (CITA-Alzheimer Foundation) ;
Ecay-Torres, Mirian (CITA-Alzheimer Foundation) ;
Tomassen, Jori (Vrije Universiteit Amsterdam) ;
den Braber, Anouk (Vrije Universiteit Amsterdam) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Wallin, Anders (University of Gothenburg Sahlgrenska Academy) ;
Kettunen, Petronella (University of Oxford) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Rami, Lorena (Hopsital Clínic Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS)) ;
Chetelat, Gaël (Université de Caen-Normandie GIP Cyceron) ;
de la Sayette, Vincent (CHU de Caen) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Freund-Levi, Yvonne (Norrtälje Hospital Tiohundra) ;
Johannsen, Peter (University of Copenhagen) ;
Novak, Gerald P. (Janssen Pharmaceutical Research and Development) ;
Ramakers, Inez (Maastricht University) ;
Verhey, Frans R. (Maastricht University) ;
Visser, Pieter J. (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. [...]
2018 - 10.3389/fnagi.2018.00193
Frontiers in aging neuroscience, Vol. 10 (25 2018) , p. 193
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4.
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15 p, 1.6 MB |
Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients : Study protocol of the MindFit project randomized controlled trial
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Bermudo-Gallaguet, Adrià (Institut de Recerca Sant Joan de Déu) ;
Ariza, Mar (Universitat de Barcelona) ;
Dacosta Aguayo, Rosalia (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Agudelo, Daniela (Universitat de Barcelona) ;
Camins-Vila, Neus (Institut Nacional d'Educació Física de Catalunya) ;
Boldo Alcaine, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrera, Òscar (Universitat de Barcelona) ;
Vidal, Sandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Uris, Blai (Institut Nacional d'Educació Física de Catalunya) ;
Busquets, Albert (Institut Nacional d'Educació Física de Catalunya) ;
Via, Marc (Institut de Recerca Sant Joan de Déu) ;
Pera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cáceres, Cynthia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomis, Meritxell (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Molina, Alberto (Institut Germans Trias i Pujol. Institut Guttmann) ;
Tormos, Jose M (Institut Germans Trias i Pujol. Institut Guttmann) ;
Arrabé, Ana (Universidad Complutense de Madrid) ;
Diez, Gustavo (Universidad Complutense de Madrid) ;
Durà Mata, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torán Montserrat, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soriano-Raya, Juan José (Universitat de Barcelona) ;
Domènech, Sira (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perera-Lluna, Alexandre (Universitat Politècnica de Catalunya) ;
Erickson, Kirk I. (Universidad de Granada) ;
Mataró, Maria (Institut de Recerca Sant Joan de Déu) ;
Universitat Autònoma de Barcelona
Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. [...]
2022 - 10.3389/fnagi.2022.936077
Frontiers in aging neuroscience, Vol. 14 (september 2022)
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14 p, 3.0 MB |
Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset
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Homann, Jan (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Osburg, Tim (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Deecke, Laura (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Bos, Isabelle (Vrije Universiteit Amsterdam) ;
Vandenberghe, Rik (Neurology Service. University Hospital Leuven) ;
Gabel, Silvy (Laboratory for Cognitive Neurology. Department of Neurosciences. KU Leuven) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Engelborghs, Sebastiaan (Vrije Universiteit Amsterdam) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Institut Neurosciences Timone. AIX Marseille University) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline RD) ;
Bordet, Régis (Lille Neuroscience and Cognition. University of Lille. Inserm. CHU Lille) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ;
Clark, Christopher (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zurich) ;
Peyratout, Gwendoline (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ;
Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Dobson, Richard J.B. (NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust) ;
Legido-Quigley, Cristina (King's College London. Institute of Pharmaceutical Sciences) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College London) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (University College London. UK Dementia Research Institute) ;
Lovestone, Simon (University of Oxford. Department of Psychiatry) ;
Streffer, Johannes ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Vos, Stephanie J.B. (Maastricht University) ;
Barkhof, Frederik (University College London) ;
Visser, Pieter Jeller (Karolinska Institutet. Department of Neurobiology) ;
Bertram, Lars (University of Oslo)
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. [...]
2022 - 10.3389/fnagi.2022.840651
Frontiers in aging neuroscience, Vol. 14 (March 2022) , p. 840651
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15 p, 2.8 MB |
Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy
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Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron) ;
Vert, Carla (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Martínez-Zabaleta, Maite (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arenillas, Juan F. (Universidad de Valladolid) ;
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Domínguez-Mayoral, Ana (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mauri, Gerard (Hospital Universitari Arnau de Vilanova) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-β (Aβ) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) in the elderly. CAA is associated with magnetic resonance imaging (MRI) markers of small vessel disease (SVD). [...]
2023 - 10.3389/fnagi.2023.1134399
Frontiers in aging neuroscience, Vol. 15 (april 2023)
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19 p, 1.5 MB |
Neurofilaments contribution in clinic : state of the art
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Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ;
Bousiges, Olivier (Laboratoire de biochimie et biologie moléculaire (LBBM)-Pôle de biologie Hôpital de Hautepierre-CHU de Strasbourg. CNRS. laboratoire ICube UMR 7357 et FMTS (Fédération de Médecine Translationnelle de Strasbourg). équipe IMIS) ;
Bouvier, Damien (Service de Biochimie et Génétique Moléculaire. CHU de Clermont-Ferrand) ;
Fillée, Catherine (Cliniques universitaires Saint-Luc UCLouvain. Service de Biochimie Médicale) ;
Fourier, Anthony (Biochimie et Biologie Moléculaire-LBMMS. Unité de diagnostic des pathologies dégénératives. Centre de Biologie et Pathologie Est. Groupement Hospitalier Est) ;
Mondésert, Etienne (Université de Montpellier. IRMB. INM. INSERM. CHU de Montpellier. Laboratoire Biochimie-Protéomique clinique) ;
Nezry, Nicolas (Univ. Lille. Inserm. CHU Lille. UMR-S-U1172. LiCEND. Lille Neuroscience Cognition. LabEx DISTALZ) ;
Omar, Souheil (Laboratoire de biologie médicale de l'Institut de Neurologie de Tunis) ;
Quadrio, Isabelle (Biochimie et Biologie Moléculaire-LBMMS. Unité de diagnostic des pathologies dégénératives. Centre de Biologie et Pathologie Est. Groupement Hospitalier Est) ;
Rucheton, Benoit (Laboratoire de Biologie. Institut Bergonié) ;
Schraen-Maschke, Susanna (Univ. Lille. Inserm. CHU Lille. UMR-S-U1172. LiCEND. Lille Neuroscience Cognition. LabEx DISTALZ) ;
van Pesch, Vincent (Cliniques universitaires Saint-Luc UCLouvain. Service de Neurologie) ;
Vicca, Stéphanie (Hôpital Necker-Enfants malades. Paris. Laboratoire de Biochimie générale. DMU BioPhyGen. AP-HP.Centre-Université de Paris) ;
Lehmann, Sylvain (Université de Montpellier. IRMB. INM. INSERM. CHU de Montpellier. Laboratoire Biochimie-Protéomique clinique) ;
Bedel, Aurelie (Service de Biochimie. CHU Pellegrin) ;
Universitat Autònoma de Barcelona
Neurological biomarkers are particularly valuable to clinicians as they can be used for diagnosis, prognosis, or response to treatment. This field of neurology has evolved considerably in recent years with the improvement of analytical methods, allowing the detection of biomarkers not only in cerebrospinal fluid (CSF) but also in less invasive fluids like blood. [...]
2022 - 10.3389/fnagi.2022.1034684
Frontiers in aging neuroscience, Vol. 14 (january 2022) , p. 1034684
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8 p, 1.7 MB |
Plasma Proteomic Biomarkers Relating to Alzheimer's Disease : A Meta-Analysis Based on Our Own Studies
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Shi, L. (Department of Psychiatry. University of Oxford) ;
Buckley, Noel J (Department of Psychiatry. University of Oxford) ;
Bos, Isabelle (Alzheimer Center. VU University Medical Center) ;
Engelborghs, Sebastiaan (Department of Neurology. Universitair Ziekenhuis Brussel. Center for Neurociences (C4N). Vrije Universiteit Brussel) ;
Sleegers, Kristel (Institute Born-Bunge. Department of Biomedical Sciences. University of Antwerp) ;
Frisoni, Giovanni B. (University of Geneva. Department of Psychiatry) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry. The Sahlgrenska Academy at the University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Zetterberg, Henrik (Department of Neurodegenerative Disease. UCL Institute of Neurology) ;
Visser, P.J. (Alzheimer Center. VU University Medical Center) ;
Bertram, Lars (Department of Psychology. University of Oslo) ;
Lovestone, S. ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Background and Objective: Plasma biomarkers for the diagnosis and stratification of Alzheimer's disease (AD) are intensively sought. However, no plasma markers are well established so far for AD diagnosis. [...]
2021 - 10.3389/fnagi.2021.712545
Frontiers in aging neuroscience, Vol. 13 (July 2021) , p. 712545
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7 p, 312.9 KB |
Evaluation of AQP4 functional variants and its association with fragile X-associated tremor/ataxia syndrome
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Elias-Mas, Andrea (Universitat de Barcelona) ;
Potrony, Miriam (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Bague, Jaume (Hospital Clínic i Provincial de Barcelona) ;
Cutler, David J. (Emory University School of Medicine) ;
Álvarez-Mora, María Isabel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Torres, Teresa (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Barcos, Tamara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Puig-Butille, Joan Anton (Hospital Clínic i Provincial de Barcelona) ;
Rubio, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Madrigal, Irene (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Puig, Susana (Hospital Clínic i Provincial de Barcelona) ;
Allen, Emily G. (Emory University School of Medicine (Estats Units d'Amèrica)) ;
Rodriguez-Revenga, Laia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Universitat Autònoma de Barcelona
Fragile X-associated tremor/ataxia syndrome (FXTAS, OMIM# 300623) is a late-onset neurodegenerative disorder with reduced penetrance that appears in adult FMR1 premutation carriers (55-200 CGGs). Clinical symptoms in FXTAS patients usually begin with an action tremor. [...]
2023 - 10.3389/fnagi.2022.1073258
Frontiers in aging neuroscience, Vol. 14 (january 2023)
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