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8 p, 167.3 KB |
Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors
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Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bracho, Maria Alma (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Valero, Oliver (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Ardèvol, Mercè (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González-Candelas, Fernando (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Current treatment of chronic hepatitis C virus (HCV) infection has limited efficacy −especially among genotype 1 infected patients−, is costly, and involves severe side effects. Thus, predicting non-response is of major interest for both patient wellbeing and health care expense. [...]
2010 -  10.1371/journal.pone.0014132
PloS one, Vol. 5 (november 2010)
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2.
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8 p, 260.1 KB |
Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients
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Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bascuñana, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordana-Lluch, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casanovas, Sònia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ardèvol, Mercè (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Only about 50% of patients chronically infected with HCV genotype 1 (HCV-1) respond to treatment with pegylated interferon-alfa and ribavirin (dual therapy), and protease inhibitors have to be administered together with these drugs increasing costs and side-effects. [...]
2013 - 10.1371/journal.pone.0072600
PloS one, Vol. 8 (august 2013)
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3.
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9 p, 126.2 KB |
Rapid Diagnosis of Bloodstream Infections with PCR Followed by Mass Spectrometry
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Jordana-Lluch, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carolan, Heather E. (Ibis Biosciences, an Abbott company, Carlsbad, California, United States of America) ;
Giménez, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sampath, Rangarajan (Ibis Biosciences, an Abbott company, Carlsbad, California, United States of America) ;
Ecker, David J. (Ibis Biosciences, an Abbott company, Carlsbad, California, United States of America) ;
Quesada, M. Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mòdol, Josep M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arméstar, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blyn, Lawrence B. (Ibis Biosciences, an Abbott company, Carlsbad, California, United States of America) ;
Cummins, Lendell L. (Ibis Biosciences, an Abbott company, Carlsbad, California, United States of America) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Achieving a rapid microbiological diagnosis is crucial for decreasing morbidity and mortality of patients with a bloodstream infection, as it leads to the administration of an appropriate empiric antimicrobial therapy. [...]
2013 - 10.1371/journal.pone.0062108
PloS one, Vol. 8 (april 2013)
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4.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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14 p, 1.7 MB |
Is systematic training in opioid overdose prevention effective?
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Espelt, Albert 1981- (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Bosque Prous, Marina (Agència de Salut Pública de Barcelona) ;
Folch, Cinta (Institut Germans Trias i Pujol. Centre d'Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya) ;
Sarasa Renedo, Ana (Instituto de Salud Carlos III. Programa de Epidemiología Aplicada y de Campo (PEAC)) ;
Majó, Xavier (Generalitat de Catalunya. Departament de Salut) ;
Casabona-Barbarà, Jordi (Generalitat de Catalunya. Departament de Salut) ;
Brugal, María Teresa (Agència de Salut Pública de Barcelona) ;
Esteve, Anna ;
Montoliu, Alexandra ;
Muñoz, Rafa ;
González Soler, Victoria ;
Ausina, Vicente ;
Vecino, Carmen ;
Colom, Joan (Colom Farran) ;
Meroño, Mercè ;
Altabas, Anna
The objectives were to analyze the knowledge about overdose prevention, the use of naloxone, and the number of fatal overdoses after the implementation of Systematic Training in Overdose Prevention (STOOP) program. [...]
2017 - 10.1371/journal.pone.0186833
PloS one, Vol. 12, núm. 10 (october 2017) , p. e0186833
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13 p, 2.4 MB |
Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
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Martínez, Isidoro (Centro Nacional de Microbiología (Espanya)) ;
Oliveros, Juan C. (Centro Nacional de Biotecnologia) ;
Cuesta, Isabel (Centro Nacional de Microbiología (Espanya)) ;
de la Barrera, Jorge (Centro Nacional de Microbiología (Espanya)) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casals, Cristina (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
de Lorenzo, Alba (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
García, Ernesto (Centro de Investigaciones Biológicas (Madrid)) ;
García Fojeda, Belén (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Garmendia, Junkal (Universidad Pública de Navarra. Instituto de Agrobiotecnología) ;
González Nicolau, Mar (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Menéndez, Margarita (Instituto de Química Física "Rocasolano") ;
Moranta, D. (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Nieto, Amelia (Centro Nacional de Biotecnologia) ;
Ortín, Juan (Centro Nacional de Biotecnologia) ;
Pérez González, Alicia (Centro Nacional de Biotecnologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramos Sevillano, Elisa (Centro de Investigaciones Biológicas (Madrid)) ;
Regueiro, Verónica (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Rodriguez Frandsen, Ariel (Centro Nacional de Biotecnologia) ;
Solís, Dolores (Instituto de Química Física "Rocasolano") ;
Yuste, José (Centro de Investigaciones Biológicas (Madrid)) ;
Bengoechea, José A. (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Melero, José A. (Centro Nacional de Microbiología (Espanya)) ;
Universitat Autònoma de Barcelona
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. [...]
2017 - 10.3389/fmicb.2017.00276
Frontiers in microbiology, Vol. 8 (2017) , p. 1-13
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15 p, 1.2 MB |
Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line
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Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano, Victoria (Institut d'Investigació Sanitària de Palma) ;
Moranta, D. (Institut d'Investigació Sanitària de Palma) ;
Regueiro, Verónica (Institut d'Investigació Sanitària de Palma) ;
Domínguez Villanueva, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González-Nicolau, M. (Institut d'Investigació Sanitària de Palma) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bengoechea, J. A. (Centre for Experimental Medicine, Queen's University Belfast) ;
Universitat Autònoma de Barcelona
Objective : Staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. Previous studies have highlighted the intracellular capacity of S. aureus in several phagocytic and non-phagocytic cells. [...]
2017 - 10.1080/21505594.2017.1361089
Virulence, Vol. 8 (september 2017) , p. 1761-1775
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13 p, 336.9 KB |
Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease
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Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Andreo García, Felipe (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lores, Luis (Hospital de Sant Boi, Sant Boi de Llobregat) ;
Ruiz Manzano, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The identification of biological markers in order to assess different aspects of COPD is an area of growing interest. The objective of this study was to investigate whether levels of procalcitonin (PCT), C-reactive protein (CRP), and neopterin in COPD patients could be useful in identifying the etiological origin of the exacerbation and assessing its prognosis. [...]
2011 - 10.2147/COPD.S16070
International journal of COPD, Vol. 6 (february 2011) , p. 157-169
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4 p, 109.6 KB |
Evaluation of the automatic ELISA Triturus analyser
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Blanco, S. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez, O. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, D. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Galí Vila, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matas, L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Galimany, R. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The objective was to evaluate the automatic ELISA Triturus analyser in order to assess its practicability and imprecision. The analyser was evaluated according to the guidelines of the Spanish Society of Clinical Chemistry. [...]
2003 - 10.1080/14639240305421
Journal of Automated Methods and Management in Chemistry, Vol. 25 (2003) , p. 31-34
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